The DLK gene is a transcriptional target of PPARγ

Biochemical Journal

Volumn 438, Issue 1, 2011, Pages 93-101

  Couture, Jean Philippe ^a   Blouin, Richard ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Dual leucine zipper bearing kinase (DLK); Neuron; Peroxisome proliferator activated receptor (PPAR ); Retinoid X receptor (RXR); Rosiglitazone; Transcriptional regulation

Indexed keywords

CELL NUCLEUS RECEPTOR; DUAL LEUCINE ZIPPER BEARING KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME REGULATION; GENE ACTIVATION; GENE DELETION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LENTIVIRUS; MEMBRANE PROTEINS; MICE; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; THIAZOLIDINEDIONES; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 79960806736     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101840     Document Type: Article

References (39)

1. Zhu, Y., Qi, C., Korenberg, J. R., Chen, X. N., Noya, D., Rao, M. S. and Reddy, J. K. (1995) Structural organization of mouse peroxisome proliferator-activated receptor γ (mPPARγ ) gene: alternative promoter use and different splicing yield two mPPARγ isoforms. Proc. Natl. Acad. Sci. U.S.A. 92, 7921-7925
2. Nolte, R. T., Wisely, G. B., Westin, S., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K. and Milburn, M. V. (1998) Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ . Nature 395, 137-143
3. Guan, H. P., Ishizuka, T., Chui, P. C., Lehrke, M. and Lazar, M. A. (2005) Corepressors selectively control the transcriptional activity of PPARγ in adipocytes. Genes Dev. 19, 453-461
4. Perissi, V. and Rosenfeld, M. G. (2005) Controlling nuclear receptors: the circular logic of cofactor cycles. Nat. Rev. Mol. Cell Biol. 6, 542-554
5. Tontonoz, P., Hu, E. and Spiegelman, B. M. (1994) Stimulation of adipogenesis in fibroblasts by PPARγ 2, a lipid-activated transcription factor. Cell 79, 1147-1156
6. Ren, D., Collingwood, T. N., Rebar, E. J., Wolffe, A. P. and Camp, H. S. (2002) PPARγ knockdown by engineered transcription factors: exogenous PPARγ 2 but not PPARγ 1 reactivates adipogenesis. Genes Dev. 16, 27-32
7. Nolan, J. J., Ludvik, B., Beerdsen, P., Joyce, M. and Olefsky, J. (1994) Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331, 1188-1193
8. Okuno, A., Tamemoto, H., Tobe, K., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H. et al. (1998) Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J. Clin. Invest. 101, 1354-1361
9. Li, M., Pascual, G. and Glass, C. K. (2000) Peroxisome proliferator-activated receptor γ -dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 20, 4699-4707
10. Sundararajan, S., Jiang, Q., Heneka, M. and Landreth, G. (2006) PPARγ as a therapeutic target in central nervous system diseases. Neurochem. Int. 49, 136-144
11. Couture, J. P., Daviau, A., Fradette, J. and Blouin, R. (2009) The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. PLoS ONE 4, e4743
12. Holzman, L. B., Merritt, S. E. and Fan, G. (1994) Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases. J. Biol. Chem. 269, 30808-30817
13. Hirai, S., Cui de, F., Miyata, T., Ogawa, M., Kiyonari, H., Suda, Y., Aizawa, S., Banba, Y. and Ohno, S. (2006) The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J. Neurosci. 26, 11992-12002
14. Bloom, A. J., Miller, B. R., Sanes, J. R. and DiAntonio, A. (2007) The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes Dev. 21, 2593-2606 (Pubitemid 47607670)
15. Miller, B. R., Press, C., Daniels, R. W., Sasaki, Y., Milbrandt, J. and DiAntonio, A. (2009) A dual leucine kinase-dependent axon self-destruction program promotes wallerian degeneration. Nat. Neurosci. 12, 387-389
16. Robitaille, K., Daviau, A., Lachance, G., Couture, J. P. and Blouin, R. (2008) Calphostin C-induced apoptosis is mediated by a tissue transglutaminase-dependent mechanism involving the DLK/JNK signaling pathway. Cell Death Differ. 15, 1522-1531
17. Robitaille, K., Daviau, A., Tucholski, J., Johnson, G. V., Rancourt, C. and Blouin, R. (2004) Tissue transglutaminase triggers oligomerization and activation of dual leucine zipper-bearing kinase in calphostin C-treated cells to facilitate apoptosis. Cell Death Differ. 11, 542-549 (Pubitemid 38660139)
18. Plaumann, S., Blume, R., Borchers, S., Steinfelder, H. J., Knepel, W. and Oetjen, E. (2008) Activation of the dual-leucine-zipper-bearing kinase and induction of β-cell apoptosis by the immunosuppressive drug cyclosporin A. Mol. Pharmacol. 73, 652-659
19. Reddy, U. R., Basu, A., Bannerman, P., Ikegaki, N., Reddy, C. D. and Pleasure, D. (1999) ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation. Oncogene 18, 4474-4484 (Pubitemid 29396655)
20. Robitaille, H., Proulx, R., Robitaille, K., Blouin, R. and Germain, L. (2005) The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation. J. Biol. Chem. 280, 12732-12741
21. Daviau, A., Di Fruscio, M. and Blouin, R. (2009) The mixed-lineage kinase DLK undergoes src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF). Cell. Signalling 21, 577-587
22. Eto, K., Kawauchi, T., Osawa, M., Tabata, H. and Nakajima, K. (2010) Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth. Neurosci. Res. 66, 37-45
23. Couture, J. P. and Blouin, R. (2009) DLK., UCSD-Native Molecule Pages, doi:10.1038/mp.a000775.01
24. Itoh, A., Wang, Z., Ito, Y., Reddy, U. R. and Itoh, T. (2004) SP3 acts as a positive regulator on the core promoter of human ZPK gene. Biochem. Biophys. Res. Commun. 313, 612-618
25. Li, L., He, S., Sun, J. M. and Davie, J. R. (2004) Gene regulation by Sp1 and Sp3. Biochem. Cell Biol. 82, 460-471
26. Douziech, M., Laberge, G., Grondin, G., Daigle, N. and Blouin, R. (1999) Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells. J. Histochem. Cytochem. 47, 1287-1296
27. Reddy, U. R. and Pleasure, D. (1994) Cloning of a novel putative protein kinase having a leucine zipper domain from human brain. Biochem. Biophys. Res. Commun. 202, 613-620
28. Kolak, M., Yki-Jarvinen, H., Kannisto, K., Tiikkainen, M., Hamsten, A., Eriksson, P. and Fisher, R. M. (2007) Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 92, 720-724
29. Cullingford, T. E., Bhakoo, K., Peuchen, S., Dolphin, C. T., Patel, R. and Clark, J. B. (1998) Distribution of mRNAs encoding the peroxisome proliferator-activated receptor α, β, and γ and the retinoid X receptor α, β, and γ in rat central nervous system. J. Neurochem. 70, 1366-1375
30. Nadeau, A., Grondin, G. and Blouin, R. (1997) In situ hybridization analysis of ZPK gene expression during murine embryogenesis. J. Histochem. Cytochem. 45, 107-118
31. Evangelopoulos, M. E., Weis, J. and Kruttgen, A. (2005) Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR. Oncogene 24, 3309-3318 (Pubitemid 40695112)
32. Zhao, X., Strong, R., Zhang, J., Sun, G., Tsien, J. Z., Cui, Z., Grotta, J. C. and Aronowski, J. (2009) Neuronal PPARγ deficiency increases susceptibility to brain damage after cerebral ischemia. J. Neurosci. 29, 6186-6195
33. Chaggar, P. S., Shaw, S. M. and Williams, S. G. (2009) Review article: thiazolidinediones and heart failure. Diab. Vasc. Dis. Res. 6, 146-152
34. McDonough, A. K., Rosenthal, R. S., Cao, X. and Saag, K. G. (2008) The effect of thiazolidinediones on BMD and osteoporosis. Nat. Clin. Pract. Endocrinol. Metab. 4, 507-513
35. Kaul, S., Bolger, A. F., Herrington, D., Giugliano, R. P. and Eckel, R. H. (2010) Thiazolidinedione drugs and cardiovascular risks: a science advisory from the American Heart Association and American College of Cardiology Foundation. Circulation 121, 1868-1877
36. Choi, J. H., Banks, A. S., Estall, J. L., Kajimura, S., Bostrom, P., Laznik, D., Ruas, J. L., Chalmers, M. J., Kamenecka, T. M., Bluher, M. et al. (2010) Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5. Nature 466, 451-456
37. Hammarlund, M., Nix, P., Hauth, L., Jorgensen, E. M. and Bastiani, M. (2009) Axon regeneration requires a conserved MAP kinase pathway. Science 323, 802-806
38. Risner, M. E., Saunders, A. M., Altman, J. F., Ormandy, G. C., Craft, S., Foley, I. M., Zvartau-Hind, M. E., Hosford, D. A. and Roses, A. D. (2006) Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J. 6, 246-254
39. Pedersen, W. A. and Flynn, E. R. (2004) Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease. Neurobiol. Dis. 17, 500-506