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Volumn 2, Issue 2, 2011, Pages 91-95

The role of endogenous aryl hydrocarbon receptor signaling in cardiovascular physiology

Author keywords

Aryl hydrocarbon receptor; blood pressure; cardiac hypertrophy; hypertension; hypotension

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; NITRIC OXIDE;

EID: 79960796760     PISSN: 09753583     EISSN: 09762833     Source Type: Journal    
DOI: 10.4103/0975-3583.83033     Document Type: Review
Times cited : (74)

References (45)
  • 2
    • 0033531928 scopus 로고    scopus 로고
    • Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor
    • Kazlauskas A, Poellinger L, Pongratz I. Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor. J Biol Chem 1999; 274:13519-24.
    • (1999) J Biol Chem , vol.274 , pp. 13519-13524
    • Kazlauskas, A.1    Poellinger, L.2    Pongratz, I.3
  • 3
    • 0031002895 scopus 로고    scopus 로고
    • A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • DOI 10.1074/jbc.272.14.8878
    • Ma Q, Whitlock JP Jr. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 1997; 272:8878-84. (Pubitemid 27154882)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.14 , pp. 8878-8884
    • Ma, Q.1    Whitlock Jr., J.P.2
  • 4
    • 0031882767 scopus 로고    scopus 로고
    • Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity
    • Meyer BK, Pray-Grant MG, Vanden Heuvel JP, Perdew GH. Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol Cell Biol 1998;18:978-88. (Pubitemid 28063432)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.2 , pp. 978-988
    • Meyer, B.K.1    Pray-Grant, M.G.2    Vanden Heuvel, J.P.3    Perdew, G.H.4
  • 5
    • 0020010617 scopus 로고
    • 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
    • Poland A, Knutson JC. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 1982;22:517-54.
    • (1982) Annu Rev Pharmacol Toxicol , vol.22 , pp. 517-554
    • Poland, A.1    Knutson, J.C.2
  • 7
    • 0023518502 scopus 로고
    • The murine Ah locus: A new allele and mapping to chromosome 12
    • Poland A, Glover E, Taylor BA. The murine Ah locus: A new allele and mapping to chromosome 12. Mol Pharmacol 1987;32:471-8. (Pubitemid 18006147)
    • (1987) Molecular Pharmacology , vol.32 , Issue.4 , pp. 471-478
    • Poland, A.1    Glover, E.2    Taylor, B.A.3
  • 8
    • 0025074762 scopus 로고
    • b-3 alleles
    • Poland A, Glover E. Characterization and strain distribution pattern of the murine Ah receptor specifed by the Ahd and Ahb-3 alleles. Mol Pharmacol 1990;38:306-12. (Pubitemid 20291567)
    • (1990) Molecular Pharmacology , vol.38 , Issue.3 , pp. 306-312
    • Poland, A.1    Glover, E.2
  • 9
    • 0027944549 scopus 로고
    • Analysis of the four alleles of the murine aryl hydrocarbon receptor
    • Poland A, Palen D, Glover E. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 1994;46:915-21. (Pubitemid 24364105)
    • (1994) Molecular Pharmacology , vol.46 , Issue.5 , pp. 915-921
    • Poland, A.1    Palen, D.2    Glover, E.3
  • 12
    • 39749126841 scopus 로고    scopus 로고
    • Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude
    • DOI 10.1161/HYPERTENSIONAHA.107.100586
    • Lund AK, Agbor LN, Zhang N, Baker A, Zhao H, Fink GD, et al. Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude. Hypertension 2008;51:803-9. (Pubitemid 351301539)
    • (2008) Hypertension , vol.51 , Issue.3 , pp. 803-809
    • Lund, A.K.1    Agbor, L.N.2    Zhang, N.3    Baker, A.4    Zhao, H.5    Fink, G.D.6    Kanagy, N.L.7    Walker, M.K.8
  • 13
    • 39049106721 scopus 로고    scopus 로고
    • Crosstalk between the aryl hydrocarbon receptor and hypoxia on the constitutive expression of cytochrome P4501A1 m RNA
    • Zhang N, Walker MK. Crosstalk between the aryl hydrocarbon receptor and hypoxia on the constitutive expression of cytochrome P4501A1 m RNA. Cardiovasc Toxicol 2007;7:282-90.
    • (2007) Cardiovasc Toxicol , vol.7 , pp. 282-290
    • Zhang, N.1    Walker, M.K.2
  • 14
    • 33646882555 scopus 로고    scopus 로고
    • A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo
    • DOI 10.1016/j.abb.2006.02.008, PII S0003986106000610
    • Henry EC, Bemis JC, Henry O, Kende AS, Gasiewicz TA. A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo. Arch Biochem Biophys 2006;450:67-77. (Pubitemid 43782737)
    • (2006) Archives of Biochemistry and Biophysics , vol.450 , Issue.1 , pp. 67-77
    • Henry, E.C.1    Bemis, J.C.2    Henry, O.3    Kende, A.S.4    Gasiewicz, T.A.5
  • 16
    • 0033535843 scopus 로고    scopus 로고
    • Lipoxin A4: A new class of ligand for the Ah receptor
    • Schaldach CM, Riby J, Bjeldanes LF. Lipoxin A4: A new class of ligand for the Ah receptor. Biochemistry 1999;38:7594-600.
    • (1999) Biochemistry , vol.38 , pp. 7594-7600
    • Schaldach, C.M.1    Riby, J.2    Bjeldanes, L.F.3
  • 17
    • 0030861704 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-dependent induction of Cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells
    • Sinal CJ, Bend JR. Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells. Mol Pharmacol 1997;52:590-9. (Pubitemid 27443980)
    • (1997) Molecular Pharmacology , vol.52 , Issue.4 , pp. 590-599
    • Sinal, C.J.1    Bend, J.R.2
  • 18
    • 0028986235 scopus 로고
    • Possible involvement of the Ah receptor in the induction of cytochrome P-450IA1 under conditions of hydrodynamic shear in microcarrier-attached hepatoma cell lines
    • Mufti NA, Bleckwenn NA, Babish JG, Shuler ML. Possible involvement of the Ah receptor in the induction of cytochrome P-450IA1 under conditions of hydrodynamic shear in microcarrier-attached hepatoma cell lines. Biochem Biophys Res Commun 1995;208:144-52.
    • (1995) Biochem Biophys Res Commun , vol.208 , pp. 144-152
    • Mufti, N.A.1    Bleckwenn, N.A.2    Babish, J.G.3    Shuler, M.L.4
  • 19
    • 0029411699 scopus 로고
    • Induction of cytochrome P-450IA1 activity in response to sublethal stresses in microcarrier-attached Hep G2 cells
    • Mufti NA, Shuler ML. Induction of cytochrome P-450IA1 activity in response to sublethal stresses in microcarrier-attached Hep G2 cells. Biotechnol Prog 1995;11:659-63. (Pubitemid 3011160)
    • (1995) Biotechnology Progress , vol.11 , Issue.6 , pp. 659-663
    • Mufti, N.A.1    Shuler, M.L.2
  • 23
    • 0029000839 scopus 로고
    • Immune system impairment and hepatic fbrosis in mice lacking the dioxin-binding Ah receptor
    • Fernandez-Salguero P, Pineau T, Hilbert DM, Mc Phail T, Lee SS, Kimura S, et al. Immune system impairment and hepatic fbrosis in mice lacking the dioxin-binding Ah receptor. Science 1995;268:722-6.
    • (1995) Science , vol.268 , pp. 722-726
    • Fernandez-Salguero, P.1    Pineau, T.2    Hilbert, D.M.3    Mc Phail, T.4    Lee, S.S.5    Kimura, S.6
  • 27
    • 0042027544 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia
    • Thackaberry EA, Gabaldon DM, Walker MK, Smith SM. Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia. Cardiovasc Toxicol 2002;2:263-74.
    • (2002) Cardiovasc Toxicol , vol.2 , pp. 263-274
    • Thackaberry, E.A.1    Gabaldon, D.M.2    Walker, M.K.3    Smith, S.M.4
  • 29
    • 0344393077 scopus 로고    scopus 로고
    • Cardiac hypertrophy in Aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1, and mean arterial blood pressure
    • DOI 10.1016/j.taap.2003.08.008
    • Lund AK, Goens MB, Kanagy NL, Walker MK. Cardiac hypertrophy in aryl hydrocarbon receptor null mice is correlated with elevated angiotensin II, endothelin-1, and mean arterial blood pressure. Toxicol Appl Pharmacol 2003;193:177-87. (Pubitemid 37476433)
    • (2003) Toxicology and Applied Pharmacology , vol.193 , Issue.2 , pp. 177-187
    • Lund, A.K.1    Goens, M.B.2    Kanagy, N.L.3    Walker, M.K.4
  • 30
    • 33645794016 scopus 로고    scopus 로고
    • Characterizing the role of endothelin-1 in the progression of cardiac hypertrophy in aryl hydrocarbon receptor (Ah R) null mice
    • Lund AK, Goens MB, Nunez BA, Walker MK. Characterizing the role of endothelin-1 in the progression of cardiac hypertrophy in aryl hydrocarbon receptor (Ah R) null mice. Toxicol Appl Pharmacol 2006;212:127-35.
    • (2006) Toxicol Appl Pharmacol , vol.212 , pp. 127-135
    • Lund, A.K.1    Goens, M.B.2    Nunez, B.A.3    Walker, M.K.4
  • 31
    • 77952672148 scopus 로고    scopus 로고
    • An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice
    • Zhang N, Agbor LN, Scott JA, Zalobowski T, Elased KM, Trujillo A, et al. An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice. Biochem Pharmacol 2010; 80:197-204.
    • (2010) Biochem Pharmacol , vol.80 , pp. 197-204
    • Zhang, N.1    Agbor, L.N.2    Scott, J.A.3    Zalobowski, T.4    Elased, K.M.5    Trujillo, A.6
  • 32
    • 78951485465 scopus 로고    scopus 로고
    • Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene
    • Sauzeau V, Carvajal-Gonzalez JM, Riolobos AS, Sevilla MA, Menacho-Marquez M, Roman AC, et al. Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene. J Biol Chem 2011; 286:2896-909.
    • (2011) J Biol Chem , vol.286 , pp. 2896-2909
    • Sauzeau, V.1    Carvajal-Gonzalez, J.M.2    Riolobos, A.S.3    Sevilla, M.A.4    Menacho-Marquez, M.5    Roman, A.C.6
  • 33
    • 33645808261 scopus 로고    scopus 로고
    • Liver deformation in Ahr-null mice: Evidence for aberrant hepatic perfusion in early development
    • Harstad EB, Guite CA, Thomae TL, Bradfeld CA. Liver deformation in Ahr-null mice: Evidence for aberrant hepatic perfusion in early development. Mol Pharmacol 2006;69:1534-41.
    • (2006) Mol Pharmacol , vol.69 , pp. 1534-1541
    • Harstad, E.B.1    Guite, C.A.2    Thomae, T.L.3    Bradfeld, C.A.4
  • 35
    • 0034641727 scopus 로고    scopus 로고
    • Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-defcient mice
    • Lahvis GP, Lindell SL, Thomas RS, Mc Cuskey RS, Murphy C, Glover E, et al. Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-defcient mice. Proc Natl Acad Sci USA 2000;97:10442-7.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10442-10447
    • Lahvis, G.P.1    Lindell, S.L.2    Thomas, R.S.3    Mc Cuskey, R.S.4    Murphy, C.5    Glover, E.6
  • 37
    • 0038381492 scopus 로고    scopus 로고
    • Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor
    • DOI 10.1074/jbc.M209594200
    • Bunger MK, Moran SM, Glover E, Thomae TL, Lahvis GP, Lin BC, et al. Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem 2003;278:17767-74. (Pubitemid 36799380)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.20 , pp. 17767-17774
    • Bunger, M.K.1    Moran, S.M.2    Glover, E.3    Thomae, T.L.4    Lahvis, G.P.5    Lin, B.C.6    Bradfield, C.A.7
  • 38
    • 54349090870 scopus 로고    scopus 로고
    • Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo- p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor
    • Bunger MK, Glover E, Moran SM, Walisser JA, Lahvis GP, Hsu EL, et al. Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor. Toxicol Sci 2008;106:83-92.
    • (2008) Toxicol Sci , vol.106 , pp. 83-92
    • Bunger, M.K.1    Glover, E.2    Moran, S.M.3    Walisser, J.A.4    Lahvis, G.P.5    Hsu, E.L.6
  • 40
    • 0041669513 scopus 로고    scopus 로고
    • Impact of Agent Orange exposure among Korean Vietnam veterans
    • Kim JS, Lim HS, Cho SI, Cheong HK, Lim MK. Impact of Agent Orange exposure among Korean Vietnam veterans. Ind Health 2003;41:149-57.
    • (2003) Ind Health , vol.41 , pp. 149-157
    • Kim, J.S.1    Lim, H.S.2    Cho, S.I.3    Cheong, H.K.4    Lim, M.K.5
  • 43
    • 59649101409 scopus 로고    scopus 로고
    • Hypertension cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide
    • Kopf PG, Huwe JK, Walker MK. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Cardiovasc Toxicol 2008;8:181-93.
    • (2008) Cardiovasc Toxicol , vol.8 , pp. 181-193
    • Kopf, P.G.1    Huwe, J.K.2    Walker, M.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.