Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude

Hypertension

Volumn 51, Issue 3, 2008, Pages 803-809

  Lund, Amie K ^a   Agbor, Larry N ^a   Zhang, Nan ^a   Baker, Amy ^a   Zhao, Huawei ^c   Fink, Gregory D ^c   Kanagy, Nancy L ^b   Walker, Mary K ^a,b  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Blood pressure; Endothelin; Gene regulation; Hypertension; Oxygen

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIN 1; MESSENGER RNA; OXYGEN; SMALL INTERFERING RNA;

ACIDOSIS; ALTITUDE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN CELL; HYPERCAPNIA; HYPERTENSION; HYPOTHESIS; HYPOXEMIA; KNOCKOUT MOUSE; LUNG VENTILATION; MOUSE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE;

ALTITUDE; ANIMALS; ANOXIA; BLOOD GAS ANALYSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERTENSION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXYGEN; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; TRANSFECTION;

EID: 39749126841     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.100586     Document Type: Article

References (39)

1. Gu YZ, Hogenesch JB, Bradfield CA. The PAS superfamily: sensors of environmental and developmental signals. Annu Rev Pharmacol Toxicol. 2000;40:519-661.
2. Thackaberry EA, Gabaldon D, Walker MK, Smith SM. Aryl hydrocarbon receptor null mice exhibit cardiac hypertrophy and increased cardiac hypoxia-inducible factor 1-α in the absence of cardiac hypoxia. Cardiovasc Tox. 2002;4:263-273.
3. Fernandez-Salguero P, Ward JM, Sundberg JP, Gonzalez FJ. Lesions of aryl-hydrocarbon receptor-deficient mice. Vet Pathol. 1997;34:605-614.
4. Lund AK, Goens MB, Kanagy NL, Walker MK. Cardiac hypertrophy in aryl hydrocarbon receptor (AhR) null mice is correlated with elevated angiotensin II, endothelin-1 and mean arterial blood pressure. Toxicol Appl Pharmacol. 2003;193:177-187.
5. Lund AK, Goens MB, Nunez B, Walker MK. Characterizing the role of endothelin-1 in the progression of cardiac hypertrophy in aryl hydrocarbon receptor (AHR) null mice. Toxicol Appl Pharmacol. 2006;212:127-135.
6. Vasquez A, Atallah-Yunes N, Smith FC, You X, Chase SE, Silverstone AE, Vikstrom KL. A role for the aryl hydrocarbon receptor in cardiac physiology and function as demonstrated by AhR knockout mice. Cardiovasc Toxicol. 2003;3:153-163.
7. Ichihara S, Yamada Y, Ichihara G, Nakajima T, Li P, Kondo T, Gonzalez FJ, Murohara T. A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis. Arterioscler Thromb Vasc Biol. 2007;27:1297-1304.
8. Chan WK, Yao G, Gu YZ, Bradfield CA. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation. J Biol Chem. 1999;274:12115-12123.
9. Pollenz RS, Davarinos NA, Shearer TP. Analysis of aryl hydrocarbon receptor-mediated signaling during physiological hypoxia reveals lack of competition for the aryl hydrocarbon nuclear translocator transcription factor. Mol Pharmacol. 1999;56:1127-1137.
10. Minchenko A, Caro J. Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: role of hypoxia responsive element. Mol Cellular Biochem. 2000;208:53-62.
11. Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA. Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. J Biol Chem. 2001;276:12645-12653.
12. Zhang N, Walker MK. Crosstalk between the aryl hydrocarbon receptor and hypoxia on the constitutive expression of cytochrome P4501A1 mRNA. Cardiovasc Toxicol. 2007;7:282-290.
13. Goerre S, Wenk M, Bartsch P, Luscher TF, Niroomand F, Hohenhaus E, Oelz O, Reinhart WH. Endothelin-1 in pulmonary hypertension associated with high-altitude exposure. Circulation. 1995;91:359-364.
14. Li H, Chen SJ, Chen YF, Meng QC, Durand J, Oparil S, Elton TS. Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J Appl Physiol. 1994;77:1451-1459.
15. Elton TS, Oparil S, Taylor GR, Hicks PH, Yang RH, Jin H, Chen YF. Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am J Physiol. 1992;263:R1260-R1264.
16. Eddahibi S, Raffestin B, Clozel M, Levame M, Adnot S. Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats. Am J Physiol. 1995;268:H828-H835.
17. Fagan KA, Fouty BW, Tyler RC, Morris KG Jr, Hepler LK, Sato K, LeCras TD, Abman SH, Weinberger HD, Huang PL, McMurtry IF, Rodman DM. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest. 1999;103:291-299.
18. Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y. Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol. 2001;127:53-60.
19. Ivy DD, Yanagisawa M, Gariepy CE, Gebb SA, Colvin KL, McMurtry IF. Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats. Am J Physiol Lung Cell Mol Physiol. 2002;282:L703-L712.
20. Schweda F, Blumberg FC, Schweda A, Kammerl M, Holmer SR, Riegger GAJ, Pfeifer M, Kramer BK. Effects of chronic hypoxia on renal renin gene expression in rats. Nephrol Dial Transplant. 2000;15:11-15.
21. Ni Z, Bemanian S, Kivlighn SD, Vaziri ND. Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension. Kidney Int. 1998;54:188-192.
22. Vaziri ND, Wang ZQ. Sustained systemic arterial hypertension induced by extended hypobaric hypoxia. Kidney Int. 1996;49:1457-1463.
23. Modesti PA, Vanni S, Morabito M, Modesti A, Marchetta M, Gamberi T, Sofi F, Savia G, Mancia G, Gensini GF, Parati G. Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. Circulation. 2006;114:1410-1416.
24. Garrett MR, Saad Y, Dene H, Rapp JP. Blood pressure QTL that differentiate Dahl salt-sensitive and spontaneously hypertensive rats. Physiol Genomics. 2000;3:33-38.
25. Stoll M, Kwitek-Black AE, Cowley AW Jr, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res. 2000;10:473-482.
26. Ramos A, Moisan MP, Chaouloff F, Mormede C, Mormede P. Identification of female-specific QTLs affecting an emotionality-related behavior in rats. Mol Psychiatry. 1999;4:453-462.
27. Gambier N, Marteau JB, Batt AM, Marie B, Thompson A, Siest G, Foernzler D, Visvikis-Siest S. Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort. J Hypertens. 2006;24:2199-2205.
28. Kang HK, Dalager NA, Needham LL, Patterson DG Jr, Lees PS, Yates K, Matanoski GM. Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam. Am J Ind Med. 2006;49:875-884.
29. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415.
30. Lahvis GP, Lindell SL, Thomas RS, McCuskey RS, Murphy C, Glover E, Bentz M, Southard J, Bradfield CA. Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A. 2000;97:10442-10447.
31. Tran Duc AT, Schwab AJ, Simard A, Villeneuve L, Dupuis J. Reduction in hepatic endothelin-1 clearance in cirrhosis. Clin Sci (Lond). 2003;105:227-234.
32. Aguirre JI, Morrell NW, Long L, Clift P, Upton PD, Polak JM, Wilkins MR. Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2000;278:L981-L987.
33. Faller M, Kessler R, Sapin R, Chaouat A, Ehrhart M, Ducolone A, Weitzenblum E. Regulation of endothelin-1 at rest and during a short steady-state exercise in 21 COPD patients. Pulm Pharmacol Ther. 1998;11:151-157.
34. Cargill RI, Kiely DG, Clark RA, Lipworth BJ. Hypoxaemia and release of endothelin-1. Thorax. 1995;50:1308-1310.
35. Trakada G, Nikolaou E, Pouli A, Tsiamita M, Spiropoulos K. Endothelin-1 levels in interstitial lung disease patients during sleep. Sleep Breath. 2003;7:111-118.
36. Prabhakar NR, Jacono FJ. Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia. High Alt Med Biol. 2005;6:112-120.
37. Marticorena E, Ruiz L, Severino J, Galvez J, Penaloza D. Systemic blood pressure in white men born at sea level: changes after long residence at high altitudes. Am J Cardiol. 1969;23:364-368.
38. Palatini P, Businaro R, Berton G, Mormino P, Rossi GP, Racioppa A, Pessina AC, Dal PC. Effects of low altitude exposure on 24-hour blood pressure and adrenergic activity. Am J Cardiol. 1989;64:1379-1382.
39. Kumar R, Qadar Pasha MA, Khan AP, Gupta V, Grover SK, Norboo T, Srivastava KK, Selvamurthy W, Brahamchari SK. Association of high-altitude systemic hypertension with the deletion allele-of the angiotensin-converting enzyme (ACE) gene. Int J Biometeorol. 2003;48:10-14.