Mechanisms of H. pylori infection-induced gastric carcinogenesis

Japanese Journal of Cancer and Chemotherapy

Volumn 37, Issue 1, 2010, Pages 23-27

  Marusawa, Hiroyuki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

AID; Gastric cancer; Helicobacter pylori; Mutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CAGA PROTEIN; CYTOKINE;

ARTICLE; ATROPHIC GASTRITIS; BACTERIAL INFECTION; CARCINOGENESIS; CELL FUNCTION; CELL PROLIFERATION; CHRONIC INFLAMMATION; HELICOBACTER INFECTION; HUMAN; MALIGNANT TRANSFORMATION; NONHUMAN; STOMACH CANCER; STOMACH EPITHELIUM;

EID: 79960788898     PISSN: 03850684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Marshall BJ and Warren JR: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1: 1311-1315, 1984.
2. Uemura N, Okamoto S, Yamamoto S, et al: Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345: 784-789, 2001.
3. Aoi T, Marusawa H, Sato T, et al: Risk of subsequent development of gastric cancer in patients with previous gastric epithelial neoplasia. Gut 55: 588-589, 2006.
4. Fukase K, Kato M, Kikuchi S, et al: Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet 372: 392-397, 2008.
5. Higashi H, Tsutsumi R, Muto S, et al: SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295: 683-686, 2002. (Pubitemid 34111828)
6. Saadat, I, Higashi H, Obuse C, et al: Helicobacter pylori CagA targets PARI/MARK kinase to disrupt epithelial cell polarity. Nature 447: 330-333, 2007. (Pubitemid 46788831)
7. Azuma T, Ohtani M, Yamazaki Y, et al: Meta-analysis of the relationship between CagA seropositivity and gastric cancer. Gastroenterology 126: 1926-7, 1927-8, 2004.
8. Matsumoto Y, Marusawa H, Kinoshita K, et al: Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med 13: 470-476, 2007. (Pubitemid 46559833)
9. Honjo T, Nagaoka H, Shinkura R, et al: AID to overcome the limitations of genomic information. Nat Immunol 6: 655-661, 2005. (Pubitemid 41716738)
10. Honjo T, Kinoshita K and Muramatsu M: Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu Rev Immunol 20: 165-196, 2002.
11. Kinoshita K and Nonaka T: The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond. Int J Hematol 83: 201-207, 2006. (Pubitemid 44227992)
12. Marusawa H: Aberrant AID expression and human cancer development. Int J Biochem Cell Biol 40: 1399-1402, 2008.
13. Okazaki IM, Hiai H, Kakazu N, et al: Constitutive expression of AID leads to tumorigenesis. J Exp Med 197: 1173-1181, 2003. (Pubitemid 36570072)
14. Morisawa T, Marusawa H, Ueda Y, et al: Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression. Int J Cancer 123: 2735-2740, 2008.
15. Maekita T, Nakazawa K, Mihara M, et al: High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 12: 989-995, 2006. (Pubitemid 43259882)
16. Nakajima T, Yamashita S, Maekita T, et al: The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. Int J Cancer 124: 905-910, 2009.
17. Nakajima T, Maekita T, Oda I, et al: Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev 15: 2317-2321, 2006. (Pubitemid 44877064)