Comparative 1H NMR metabolomic urinalysis of people diagnosed with Balkan endemic nephropathy, and healthy subjects, in Romania and Bulgaria: A pilot study

Toxins

Volumn 3, Issue 7, 2011, Pages 815-833

  Mantle, Peter ^a   Modalca, Mirela ^b   Nicholls, Andrew ^c   Tatu, Calin ^d   Tatu, Diana ^d   Toncheva, Draga ^e  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Drobeta Turnu Severin   (Romania)

^c GLAXOSMITHKLINE   (United Kingdom)

^d VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^e MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Aristolochic acid; Balkan nephropathy; Haemodialysis; Metabolomics; Ochratoxin A; Urinalysis

Indexed keywords

ADULT; AGED; ARTICLE; BULGARIA; CLINICAL ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; ENDEMIC DISEASE; FEMALE; GEOGRAPHIC DISTRIBUTION; HEMODIALYSIS; HUMAN; INTERSTITIAL NEPHRITIS; MALE; METABOLOMICS; MORBIDITY; PILOT STUDY; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; ROMANIA; URINALYSIS;

AGED; BALKAN NEPHROPATHY; BIOLOGICAL MARKERS; BULGARIA; CASE-CONTROL STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PILOT PROJECTS; ROMANIA; URINALYSIS; URINARY TRACT;

EID: 79960752550     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins3070815     Document Type: Article

References (50)

1. Tanchev, Y.; Evstatiev, Z.; Dorossiev, D.; Pencheva, J.; Zvetkov, G. Studies on the nephritides in the District of Vratza. Sovrem. Med. 1956, 7, 14-29 (in Bulgarian).
2. World Health Organisation. Memoranda: The Endemic Nephropathy of South-Eastern Europe; World Health Organization: Geneva, Switzerland, 1965; pp. 431-448.
3. Wolstenholme, G.E.W.; Knight, J. Balkan Nephropathy; Churchill Livingstone: London, UK, 1967.
4. Austwick, P.K.C. Balkan nephropathy. Proc. R. Soc. Med. 1975, 68, 219-221.
5. Tanchev, Y.; Dorossiev, D. The first clinical description of Balkan endemic nephropathy (1956) and its validity 35 years later. In Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours; International Agency for Research on Cancer: Lyon, France, 1991; Volume 115, pp. 21-28.
6. Gartland, K.P.; Bonner, F.W.; Nicholson, J.K. Investigations into the biochemical effects of region-specific nephrotoxins. Mol. Pharmacol. 1989, 35, 242-250.
7. 13C NMR spectroscopy of human blood plasma. Anal. Chem. 1995, 67, 793-811.
8. Burtis, C.A.; Ashwood, E.R.; Bruns, D.E. Tietz Fundamentals of Clinical Chemistry; WB Saunders Company: Philadelphia, PA, USA, 2005.
9. Stefanovic, V.; Jelakovic, B.; Cucuranovic, R.; Bukvic, D.; Nikolic, J.; Lukic, L.; Gluhovschi, G.; Toncheva, D.; Polenakovic, M.; Cosyns, J.-P. Diagnostic criteria for Balkan endemic nephropathy: Proposal by an international panel. Ren. Fail. 2007, 29, 867-880.
10. Stefanovic, V.; Polenakovic, M. Fifty years of research in Balkan nephropathy: Where are we now? Nephron Clin. Pract. 2009, 112, c51-c56.
11. Ivic, M. The problem of etiology of endemic nephropathy. Acta Fac. Med. Naiss. 1970, 1, 29-37.
12. Dammin, G.J. Endemic nephropathy in Yugoslavia. Arch. Pathol. 1972, 93, 372-374.
13. Riquelme, C.; Escors, D.; Ortego, J.; Sanchez, C.M.; Uzelac-Keserovic, B.; Apostolov, K.; Enjuanes, L. Nature of the virus associated with endemic balkan nephropathy. Emerg. Infect. Dis. 2002, 8, 869-870.
14. van der Merwe, K.J.; Steyn, P.S.; Fourie, L. Mycotoxins II. The constitution of ochratoxins A, B, and C, metabolites of Aspergillus ochraceus Wilh. J. Chem. Soc. 1965, doi:10.1039/JR9650007083.
15. Krogh, P. Mycotoxic porcine nephropathy-a possible model for Balkan (endemic) nephropathy. In Endemic Nephropathy, Proceedings of the second International Symposium on Endemic Nephropathy; Bulgarian Academy of Sciences: Sofia, Bulgaria, 9-12 November 1972; pp. 266-277.
16. Krogh, P. Causal associations of mycotoxic nephropathy. Acta Pathol. Microbiol. Scand. Sect. A Suppl. 1978, 269, 1-28.
17. Pitt, J.I. The Genus Penicillium and Its Teleomorphic States Eupenicillium and Talaromyces; Academic Press: London, UK, 1979.
18. Barnes, J.M.; Carter, R.L.; Peristianis, G.C.; Austwick, P.K.C.; Flynn, F.V.; Aldridge, W.N. Balkan (endemic) nephropathy and a toxin-producing strain of Penicillium verrucosum var. cyclopium, an experimental model in rats. Lancet 1977, 289, 671-675.
19. Mantle, P.G.; McHugh, K.M.; Adatia, R.; Gray, T.; Turner, D.R. Persistent karyomegaly caused by Penicillium nephrotoxins in the rat. Proc. R. Soc. Lond. 1991, 246, 251-259.
20. Mantle, P.G.; Miljkovic, A.; Udupa, V.; Dobrota, M. Does apoptosis cause renal atrophy in Balkan endemic nephropathy? Lancet 1998, 352, 1118-1119.
21. Miljkovic, A. Production, chatacterisation, and mode of action of some nephtotoxic mycotoxins. Ph.D. Thesis, University of London, London, UK, 1999.
22. Toncheva, D.I.; von Ahsen, N.; Atanasova, S.Y.; Dimitrov, T.G.; Armstrong, V.W.; Oellerich, M. Identification of NQ01 and GSTs genotype frequencies in Bulgarian patients with Balkan endemic nephropathy. J. Nephrol. 2004, 17, 384-389.
23. Pavlovic, N.M.; Varghese, Z.; Persaud, J.W.; Stefanovic, V.; Strahinjic, S.; Savic, V.; Moorhead, J.F. Partial lecithin:cholesterol acyltransferase (LCAT) deficiency in Balkan endemic nephropathy. Kidney Int. 1991, 40, S102-S104.
24. Pavlovic, N.M.; Orem, W.H.; Tatu, C.A.; Lerch, H.; Bunnell, J.E.; Feder, G.L.; Kostic, E.N.; Ordodi, V.L. The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: A new hypothesis. Food Chem. Toxicol. 2008, 46, 949-954.
25. Boorman, G.A. Toxicology and Carcinogenesis Studies of Ochratoxin A; National Toxicology Program Technical Report Series No. 358, CAS NO. 303-47-9; U.S. Department of Health and Human Services Public Health Service National Institutes of Health: Bethesda, MD, USA, May 1989. NIH Publication No 89-2813.
26. Sieber, M.; Wagner, S.; Rached, E.; Amberg, A.; Mally, A.; Dekant, W. Metabonomic study of ochratoxin A toxicity in rats after repeated administration: Phenotypic anchoring enhances the ability for biomarker discovery. Chem. Res. Toxicol. 2009, 22, 1221-1231.
27. Abouzeid, M.M.; Horvath, A.D.; Podlesny, P.M.; Regina, D.P.; Metodiev, V.D.; Kamenova-Tozeva, R.M.; Niagolova, N.D.; Stein, A.D.; Petropoulos, E.A.; Ganev, V.S. Ochratoxin A concentrations in food and feed from a region with Balkan endemic nephropathy. Food Addit. Contam. 2002, 19, 755-764.
28. Vrabcheva, T.; Petkova-Bocharova, T.; Grosso, F.; Nikolov, I.; Chernozemsky, I.N.; Castegnaro, M.; Dragacci, S. Analysis of ochratoxin A in foods consumed by inhabitants from an area with Balkan endemic nephropathy: a 1 month follow-up study. J. Agric. Food Chem. 2004, 52, 2404-2410.
29. Mally, A.; Volkel, W.; Amberg, A.; Kurz, M.; Wanek, P.; Eder, E.; Hard, G.; Dekant, W. Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats. Chem. Res. Toxicol. 2005, 18, 1242-1252.
30. 1H NMR spectroscopy-based metabolomic assessment of uremic toxicity, with toxicological outcomes, in male rats following an acute, mid-life insult from ochratoxin A. Toxins 2011, 3, 504-519.
31. Mally, A.; Hard, G.C.; Dekant, W. Ochratoxin A as a potential etiologic factor in endemic nephropathy: lessons from toxicity studies in rats. Food Chem. Toxicol. 2007, 47, 2254-2260.
32. Mantle, P.G.; Amerasinghe, C.; Brown, A.L.; Herman, D.; Horn, T.; Krogh, T.; Odell, E.W.; Rosenbaum, T.; Tatu, C.A. A pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology. Toxins 2010, 2, 326-340.
33. Debelle, F.D.; Vanherweghem, J.-L.; Nortier, J.L. Aristolochic acid nephropathy: A worldwide problem. Kidney Int. 2008, 74, 158-169.
34. Cosyns, J.-P.; Dehoux, J.-P.; Guiot, Y.; Goebbels, R.-M.; Robert, A.; Bernard, A.M. Chronic aristolochic acid toxicity in rabbits: A model of Chinese herbs nephropathy? Kidney Int. 2001, 59, 2164-2173.
35. Cosyns, J.-P. Human and experimental features of aristolochic acid nephropathy: Are these relevant to Balkan endemic nephropathy? Facta Univ. 2002, 9, 49-52.
36. Cui, M.; Liu, Z.-H.; Qui, Q.; Li, H.; Li, L.-S. Tumour induction in rats following exposure to short-term high dose aristolochic acid 1. Mutagenesis 2005, 20, 45-49.
37. Grollman, A.P.; Shibutani, S.; Moriya, M.; Miller, F.; Wu, L.; Moll, U. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc. Natl. Acad. Sci. USA 2007, 104, 12129-12134.
38. Grollman, A.P.; Jelakovic, B. Role of Environmental toxins in endemic (Balkan) nephropathy. J. Am. Soc. Nephrol. 2007, 18, 2817-2823.
39. Mead, J.C. Manna from hell. Scientist 2007, 21, 44-48.
40. Barnias, G.; Boletis, J. Balkan nephropathy: evolution of our knowledge. Am. J. Kidney Dis. 2008, 52, 606-616.
41. Gluhovschi, G.; Margineanu, F.; Kaycsa, A.; Velciov, S.; Gluhovschi, C.; Bob, F.; Petrica, L.; Bozdog, G.; Dumityu, S.; Olosz, E.; et al. Therapeutic remedies based on Aristolochia clematitis in the main foci of Balkan endemic nephropathy in Romania. Nephron Clin. Pract. 2010, 116, c36-c46.
42. Long, D.T.; Voice, T.C. Role of exposure analysis in solving the mystery of Balkan endemic nephropathy. Croat. Med. J. 2007, 48, 300-311.
43. European Food Safety Authority. Opinion of the scientific panel on contaminants in the food chain on a request from the Commission related to ochratoxin A in food. EFSA J. 2006, 365, 1-56.
44. Mantle, P.G.; Faucet-Marquis, V.; Manderville, R.A.; Squillaci, B.; Pfohl-Leszkowicz, A. Structures of covalent adducts between DNA and ochratoxin A: A new factor in debate about genotoxicity and human risk assessment. Chem. Res. Toxicol. 2010, 23, 89-98.
45. Hranjec, T.; Kovac, A.; Kos, J.; Mao, W.; Chen, J.J.; Grollman, A.P.; Jelakovic, B. Endemic nephropathy: The case for chronic poisoning by Aristolochia. Croat. Med. J. 2005, 46, 116-125.
46. Austwick, P.K.C. Balkan nephropathy. Practitioner 1981, 225, 1031-1038.
47. Pfohl-Leszkowicz, A.; Tozlovanu, M.; Manderville, R.; Peraica, M.; Castegnaro, M.; Stefanovic, V. New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor. Mol. Nutr. Food Res. 2007, 51, 1131-1146.
48. Pfohl-Leszkowicz, A. Ochratoxin A and aristolochic acid involvement in nephropathies and associated urothelial tract tumours. Arh. Hig. Rada Toksikol. 2009, 60, 465-483.
49. Guzelian, P.S.; Victoroff, M.S.; Halmes, N.C.; James, R.C.; Guzelian, C.P. Evidence-based toxicology: A comprehensive framework for causation. Hum. Exp. Toxicol. 2005, 24, 161-201.
50. Mantle, P.G. The role of tryptophan as a biosynthetic precursor of indole-diterpenoid fungal metabolites: Continuing a debate. Phytochemistry 2009, 70, 7-10.