Impaired cognitive function and altered hippocampal synapse morphology in mice lacking LRRTM1, a gene associated with schizophrenia

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Takashima, Noriko ^a   Odaka, Yuri S ^a   Sakoori, Kazuto ^a   Akagi, Takumi ^a   Hashikawa, Tsutomu ^a   Morimura, Naoko ^a   Yamada, Kazuyuki ^a   Aruga, Jun ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR DISORDER; BRAIN SIZE; COGNITIVE DEFECT; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GENE; GENETIC ASSOCIATION; HIPPOCAMPUS; LIGHT DARK CYCLE; LOCOMOTION; LRRTM1 GENE; MEMORY DISORDER; MOUSE; NEUROTRANSMISSION; NONHUMAN; OBJECT RELATION; POSTSYNAPTIC DENSITY; SCHIZOPHRENIA; SOCIAL DISABILITY; SOCIAL DISCRIMINATION; SPATIAL MEMORY; SYNAPSE VESICLE; SYNAPTIC POTENTIAL; WILD TYPE; ADAPTIVE BEHAVIOR; ANIMAL; COGNITION; DRUG EFFECT; ENVIRONMENT; GENE TARGETING; GENETIC PREDISPOSITION; GENETICS; MEMORY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNAPSE; ULTRASTRUCTURE;

ANIMALIA; MUS;

CLOZAPINE; DIZOCILPINE MALEATE; FLUOXETINE; LRRTM1 PROTEIN, MOUSE; NERVE CELL ADHESION MOLECULE; NEUROLEPTIC AGENT; SEROTONIN UPTAKE INHIBITOR;

ADAPTATION, PSYCHOLOGICAL; ANIMALS; ANTIPSYCHOTIC AGENTS; BEHAVIOR, ANIMAL; CLOZAPINE; COGNITION; DIZOCILPINE MALEATE; ENVIRONMENT; FLUOXETINE; GENE TARGETING; GENETIC PREDISPOSITION TO DISEASE; HIPPOCAMPUS; MEMORY; MICE; MICE, KNOCKOUT; NEURAL CELL ADHESION MOLECULES; SCHIZOPHRENIA; SEROTONIN UPTAKE INHIBITORS; SYNAPSES;

EID: 79960750152     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022716     Document Type: Article

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