Apelin-transgenic mice exhibit a resistance against diet-induced obesity by increasing vascular mass and mitochondrial biogenesis in skeletal muscle

Biochimica et Biophysica Acta - General Subjects

Volumn 1810, Issue 9, 2011, Pages 853-862

  Yamamoto, Toshihiro ^a   Habata, Yugo ^a   Matsumoto, Yoshio ^a   Yasuhara, Yoshitaka ^a   Hashimoto, Tadatoshi ^a   Hamajyo, Hitomi ^a   Anayama, Hisashi ^a   Fujii, Ryo ^a   Fuse, Hiromitsu ^a   Shintani, Yasushi ^a   Mori, Masaaki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Ang1; Apelin; APJ; Mitochondrial biogenesis; Tie2; Vascular mass

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; APELIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; BLOOD VESSEL PARAMETERS; BODY TEMPERATURE; CONTROLLED STUDY; ENDOTHELIUM CELL; FOOD INTAKE; GENE DOSAGE; GENE EXPRESSION; LIPID DIET; MALE; MITOCHONDRIAL BIOGENESIS; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; SKELETAL MUSCLE; TRANSGENIC MOUSE; UPREGULATION; VASCULAR MASS;

ADIPOSE TISSUE; ANGIOPOIETIN-1; ANIMALS; BODY TEMPERATURE; DIETARY FATS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OBESITY; OXYGEN CONSUMPTION; RECEPTOR PROTEIN-TYROSINE KINASES;

MUS; MUS MUSCULUS;

EID: 79960743614     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2011.05.004     Document Type: Article

References (30)

1. K. Tatemoto, M. Hosoya, Y. Habata, R. Fujii, T. Kakegawa, M.X. Zou, Y. Kawamata, S. Fukusumi, S. Hinuma, C. Kitada, T. Kurokawa, H. Onda, and M. Fujino Isolation and characterization of a novel endogeneous peptide ligand for the human APJ receptor Biochem. Biophys. Res. Commun. 251 1998 471 476 (Pubitemid 28505047)
2. Y. Kawamata, Y. Habata, S. Fukusumi, M. Hosoya, R. Fujii, S. Hinuma, N. Nishizawa, C. Kitada, H. Onda, O. Nishimura, and M. Fujino Molecular properties of apelin: tissue distribution and receptor binding Biochim. Biophys. Acta. 1538 2001 162 171 (Pubitemid 32402239)
3. I. Falcão-Pires, R. Ladeiras-Lopes, and A.F. Leite-Moreira The apelinergic system: a promising therapeutic target Expert Opin. Ther. Targets. 14 2010 633 645
4. H. Kidoya, M. Ueno, Y. Yamada, N. Mochizuki, M. Nakata, T. Yano, R. Fujii, and N. Takakura Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis EMBO J. 27 2008 522 534 (Pubitemid 351225682)
5. A. Kasai, N. Shintani, H. Kato, S. Matsuda, F. Gomi, R. Haba, H. Hashimoto, M. Kakuda, Y. Tano, and A. Baba Retardation of retinal vascular development in apelin-deficient mice Arterioscler. Thromb. Vasc. Biol. 28 2008 1717 1722
6. M. Eyries, G. Siegfried, M. Ciumas, K. Montagne, M. Agrapart, F. Lebrin, and F. Soubrier Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis Circ. Res. 15 2008 432 440
7. T. Dai, G. Ramirez-Correa, and W.D. Gao Apelin increases contractility in failing cardiac muscle Eur. J. Pharmacol. 553 2006 222 228 (Pubitemid 44779594)
8. F. Lago, C. Dieguez, J. Gómez-Reino, and O. Gualillo The emerging role of adipokines as mediators of inflammation and immune responses Cytokine Growth Factor Rev. 18 2007 313 325 (Pubitemid 46891288)
9. K. Higuchi, T. Masaki, K. Gotoh, S. Chiba, I. Katsuragi, K. Tanaka, T. Kakuma, and H. Yoshimatsu Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice Endocrinology 148 2007 2690 2697 (Pubitemid 46984786)
10. C. Dray, C. Knauf, D. Daviaud, A. Waget, J. Boucher, M. Buléon, P.D. Cani, C. Attané, C. Guigné, C. Carpéné, R. Burcelin, I. Castan-Laurell, and P. Valet Apelin stimulates glucose utilization in normal and obese insulin-resistant mice Cell. Metab. 8 2008 437 445
11. J. Boucher, B. Masri, D. Daviaud, S. Gesta, C. Guigné, A. Mazzucotelli, I. Castan-Laurell, I. Tack, B. Knibiehler, C. Carpé né, Y. Audigier, J.S. Saulnier-Blache, and P. Valet Apelin, a newly identified adipokine up-regulated by insulin and obesity Endocrinology 146 2005 1764 1771 (Pubitemid 40396885)
12. Y. Kojima, R.K. Kundu, C.M. Cox, N.J. Leeper, J.A. Anderson, H.J. Chun, Z.A. Ali, E.A. Ashley, P.A. Krieg, and T. Quertermous Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse Cardiovasc. Res. 87 2010 156 165
13. H. Kidoya, H. Naito, and N. Takakura Apelin induces enlarged and non-leaky blood vessels for functional recovery from ischemia Blood 115 2010 3166 3174
14. P. Yue, H. Jin, M. Aillaud-Manzanera, A.C. Deng, J. Azuma, T. Asagami, R.K. Kundu, G.M. Reaven, T. Quertermous, and P.S. Tsao Apelin is necessary for the maintenance of insulin sensitivity Am. J. Physiol. Endocrinol. Metab. 298 2010 E59 E67
15. Y. Cao Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases Nat. Rev. Drug. Discov. 9 2010 107 115
16. M. Schorpp, R. Jäger, K. Schellander, J. Schenkel, E.F. Wagner, H. Weiher, and P. Angel The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice Nucleic Acids Res. 24 1996 1787 1788 (Pubitemid 26137941)
17. Y. Habata, R. Fujii, M. Hosoya, S. Fukusumi, Y. Kawamata, S. Hinuma, C. Kitada, N. Nishizawa, S. Murosaki, T. Kurokawa, H. Onda, K. Tatemoto, and M. Fujino Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum Biochim. Biophys. Acta. 1452 1999 25 35 (Pubitemid 29486739)
18. N. Matsumoto, T. Nakamura, Y. Yasui, and J. Torii Immunohistochemical differentiation of fibre types in human skeletal muscle using monoclonal antibodies to slow and fast isoforms of troponin I subunit Biotech. Histochem. 72 1997 191 197 (Pubitemid 27382474)
19. K. Gaengel, G. Genové, A. Armulik, and C. Betsholtz Endothelial-mural cell signalling in vascular development and angiogenesis Thromb. Vasc. Biol. 29 2009 630 638
20. B.L. Falcón, H. Hashizume, P. Koumoutsakos, J. Chou, J.V. Bready, A. Coxon, J.D. Oliner, and D.M. McDonald Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels Am. J. Pathol. 175 2009 2159 2170
21. N. Takakura, and H. Kidoya Maturation of blood vessels by haematopoietic stem cells and progenitor cells: involvement of apelin/APJ and angiopoietin/Tie2 interactions in vessel caliber size regulation Thromb. Haemost. 101 2009 999 1005
22. S. Fukuhara, K. Sako, K. Noda, J. Zhang, M. Minami, and N. Mochizuki Angiopoietin-1/Tie2 receptor signalling in vascular quiescence and angiogenesis Histol. Histopathol. 25 2010 387 396
23. T.P. Gavin, H.W. Stallings III, K.A. Zwetsloot, L.M. Westerkamp, N.A. Ryan, R.A. Moore, W.E. Pofahl, and R.C. Hickner Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans J. Appl. Physiol. 98 2005 315 321 (Pubitemid 40041262)
24. B.C. Frier, D.B. Williams, and D.C. Wright The effects of apelin treatment on skeletal muscle mitochondrial content Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 2009 R1761 R1768
25. P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, and B.M. Spiegelman A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 92 1998 829 839 (Pubitemid 28155321)
26. K. Morino, K.F. Petersen, and G.I. Shulman Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction Diabetes 55 2006 S9 S15
27. F. Soriguer, L. Garrido-Sanchez, S. Garcia-Serrano, J.M. Garcia-Almeida, J. Garcia-Arnes, F.J. Tinahones, and E. Garcia-Fuentes Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus Obes. Surg. 19 2009 1574 1580
28. Y. Zhang, C. Shen, X. Li, G. Ren, X. Fan, F. Ren, N. Zhang, J. Sun, and J. Yang Low plasma apelin in newly diagnosed type 2 diabetes in Chinese people Diabetes Care 32 2009 e150
29. B. Telejko, M. Kuzmicki, N. Wawrusiewicz-Kurylonek, J. Szamatowicz, A. Nikolajuk, A. Zonenberg, D. Zwierz-Gugala, W. Jelski, P. Laudański, J. Wilczynski, A. Kretowski, and M. Gorska Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus Diabetes Res. Clin. Pract. 87 2009 176 183
30. C. Mesmin, M. Dubois, F. Becher, F. Fenaille, and E. Ezan Liquid chromatography/tandem mass spectrometry assay for the absolute quantification of the expected circulating apelin peptides in human plasma Rapid. Commun. Mass. Spectrom 24 2010 2875 2884