Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse

Cardiovascular Research

Volumn 87, Issue 1, 2010, Pages 156-165

  Kojima, Yoko ^a   Kundu, Ramendra K ^a   Cox, Christopher M ^b   Leeper, Nicholas J ^a   Anderson, Joshua A ^a   Chun, Hyung J ^a   Ali, Ziad A ^a   Ashley, Euan A ^a   Krieg, Paul A ^b   Quertermous, Thomas ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Apelin; APJ; Migration; Smooth muscle cell; Vascular remodelling

Indexed keywords

APELIN; APELIN RECEPTOR; APOLIPOPROTEIN E; CAP BINDING PROTEIN; ANGIOTENSIN II; APLN PROTEIN, MOUSE; APLNR PROTEIN, MOUSE; CARRIER PROTEIN; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY LIGATION; CELL MIGRATION; COMMON CAROTID ARTERY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; ANIMAL; AORTA DISEASE; C57BL MOUSE; CAROTID ARTERY DISEASE; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; DEFICIENCY; DISEASE MODEL; GENETICS; INTIMA; LIGATION; METABOLISM; PARACRINE SIGNALING; PATHOLOGY; RAT; SURGERY; TIME; UPREGULATION;

ANGIOTENSIN II; ANIMALS; AORTIC DISEASES; APOLIPOPROTEINS E; CAROTID ARTERY DISEASES; CAROTID ARTERY, COMMON; CARRIER PROTEINS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; PARACRINE COMMUNICATION; RATS; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; TIME FACTORS; TUNICA INTIMA; UP-REGULATION;

EID: 77954322093     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq052     Document Type: Article

References (34)

1. O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 1993;136:355-360.
2. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998;251:471-476.
3. Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R et al. A novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation 2003;108:1432-1439.
4. Kleinz MJ, Davenport AP. Immunocytochemical localization of the endogenous vaso-active peptide apelin to human vascular and endocardial endothelial cells. Regul Pept 2004;118:119-125.
5. Kleinz MJ, Skepper JN, Davenport AP. Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept 2005;126:233-240.
6. Sheikh AY, Chun HJ, Glassford AJ, Kundu RK, Kutschka I, Ardigo D et al. In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Am J Physiol Heart Circ Physiol 2008;294:H88-H98.
7. Sorli SC, van denBerghe L, Masri B, Knibiehler B, Audigier Y. Therapeutic potential of interfering with apelin signalling. Drug Discov Today 2006;11:1100-1106.
8. Cheng X, Cheng XS, Pang CC. Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats. 2003;470:171-175.
9. Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S et al. Regulatory roles for APJ, a seven-transmembrane receptor related to AT1, in blood pressure in vivo. J Biol Chem 2004;279:26274-26279.
10. Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 2000;74:34-41.
11. Tatemoto K, Takayama K, Zou MX, Kumaki I, Zhang W, Kumano K et al. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept 2001;99:87-92.
12. Zhong JC, Huang Y, Yung LM, Lau CW, Leung FP, Wong WT et al. The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regul Pept 2007; 144:109-114.
13. Chun HJ, Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R et al. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest 2008; 118:3343-3354.
14. Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP. [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 2001;132:1255-1260.
15. Hashimoto T, Kihara M, Ishida J, Imai T, Yoshida S, Toya Y et al. Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2006;26:1267-1272.
16. Hashimoto T, Kihara M, Imai N, Yoshida S, Shimoyamada H, Yasuzaki H et al. Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis. Am J Pathol 2007;171:1705-1712.
17. Kumar A, Lindner V. Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow. Arterioscler Thromb Vasc Biol 1997;17: 2238-2244.
18. Tabibiazar R, Wagner RA, Ashley EA, King JY, Ferrara R, Spin JM et al. Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease. Physiol Genomics 2005;22:213-226.
19. Cox CM, D'Agostino SL, Miller MK, Heimark RL, Krieg PA. Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo. Dev Biol 2006;296:177-189.
20. Ishida T, Kundu RK, Yang E, Hirata K, Ho YD, Quertermous T. Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem 2003;278:34598-34604.
21. Li F, Li L, Qin X, Pan W, Feng F, Chen F et al. Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1. Front Biosci 2008;13:3786-3792.
22. Yamanouchi D, Kato K, Ryer EJ, Zhang F, Liu B. Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis. Car-diovasc Res 2010;85:434-443.
23. Liu G, Espinosa E, Oemar BS, Luscher TF. Bimodal effects of angiotensin II on migration of human and rat smooth muscle cells. Direct stimulation and indirect inhibition via transforming growth factor-beta 1. Arterioscler Thromb Vasc Biol 1997;17: 1251-1257.
24. Saint-Geniez M, Argence CB, Knibiehler B, Audigier Y. The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene Expr Patterns 2003;3:467-472.
25. Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, Quilliot D et al. TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J 2006; 20:1528-1530.
26. Han S, Wang G, Qi X, Englander EW, Greeley GH Jr. Involvement of a Stat3 binding site in inflammation-induced enteric apelin expression. Am J Physiol Gastrointest Liver Physiol 2008;295:G1068-G1078.
27. Kidoya H, Ueno M, Yamada Y, Mochizuki N, Nakata M, Yano T et al. Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J 2008;27:522-534.
28. Cheng HF, Becker BN, Burns KD, Harris RC. Angiotensin II upregulates type-1 angio-tensin II receptors in renal proximal tubule. J Clin Invest 1995;95:2012-2019.
29. Wei SG, Yu Y, Zhang ZH, Felder RB. Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway. Am J Physiol Heart Circ Physiol 2009;296:H1425-H1433.
30. Maguire JJ, Kleinz MJ, Pitkin SL, Davenport AP. [Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease. Hypertension 2009;54:598-604.
31. Goetze JP, Rehfeld JF, Carlsen J, Videbaek R, Andersen CB, Boesgaard S et al. Apelin: a new plasma marker of cardiopulmonary disease. Regul Pept 2006;133:134-138.
32. Kon V, Jabs K. Angiotensin in atherosclerosis. Curr Opin Nephrol Hypertens 2004;13: 291-297.
33. Powell JS, Clozel JP, Muller RK, Kuhn H, Hefti F, Hosang M et al. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science 1989;245:186-188.
34. Eto H, Biro S, Miyata M, Kaieda H, Obata H, Kihara T et al. Angiotensin II type 1 receptor participates in extracellular matrix production in the late stage of remodeling after vascular injury. Cardiovasc Res 2003;59:200-211.