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Volumn 71, Issue 12, 2011, Pages 1276-1286

G-protein alpha-s and -12 subunits are involved in androgen-stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells

Author keywords

androgen receptor; caveolae; G protein; prostate cancer

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANDROGEN RECEPTOR; BROXURIDINE; CAVEOLIN 1; CAVEOLIN 2; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA12 SUBUNIT; LUCIFERASE; MESSENGER RNA; METHYL BETA CYCLODEXTRIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P110; PROTEIN P110BETA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 79960732692     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21345     Document Type: Article
Times cited : (12)

References (40)
  • 1
    • 33644675811 scopus 로고    scopus 로고
    • Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis
    • DOI 10.1200/JCO.2005.03.4777
    • Scher HI, Sawyers CL,. Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol 2005; 23: 8253-8261. (Pubitemid 46211563)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.32 , pp. 8253-8261
    • Scher, H.I.1    Sawyers, C.L.2
  • 2
    • 2342558431 scopus 로고    scopus 로고
    • Androgen receptor in prostate cancer
    • DOI 10.1210/er.2002-0032
    • Heinlein CA, Chang C,. Androgen receptor in prostate cancer. Endocr Rev 2004; 25: 276-308. (Pubitemid 38501396)
    • (2004) Endocrine Reviews , vol.25 , Issue.2 , pp. 276-308
    • Heinlein, C.A.1    Chang, C.2
  • 3
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman BJ, Feldman D,. The development of androgen-independent prostate cancer. Nat Rev Cancer 2001; 1: 34-45. (Pubitemid 33741879)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 4
    • 20444403792 scopus 로고    scopus 로고
    • The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: Modifications to the androgen receptor
    • DOI 10.1111/j.1464-410X.2005.05526.x
    • Edwards J, Bartlett JM,. The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: Modifications to the androgen receptor. BJU Int 2005; 95: 1320-1326. (Pubitemid 40799454)
    • (2005) BJU International , vol.95 , Issue.9 , pp. 1320-1326
    • Edwards, J.1    Bartlett, J.M.S.2
  • 5
    • 1542290456 scopus 로고    scopus 로고
    • G proteins in cancer: The prostate cancer paradigm
    • Daaka Y,. G proteins in cancer: The prostate cancer paradigm. Sci STKE 2004; 216: re2.
    • (2004) Sci STKE , vol.216
    • Daaka, Y.1
  • 6
    • 2542472390 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β activity is required for androgen-stimulated gene expression in prostate cancer
    • DOI 10.1210/en.2003-1519
    • Liao X, Thrasher JB, Holzbeierlein J, Stanley S, Li B,. Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer. Endocrinology 2004; 145: 2941-2949. (Pubitemid 38686243)
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2941-2949
    • Liao, X.1    Thrasher, J.B.2    Holzbeierlein, J.3    Stanley, S.4    Li, B.5
  • 7
    • 48649083369 scopus 로고    scopus 로고
    • Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers
    • Zhu Q, Youn H, Tang J, Tawfik O, Dennis K, Terranova PF, Du J, Raynal P, Thrasher JB, Li B,. Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Oncogene 2008; 27: 4569-4579.
    • (2008) Oncogene , vol.27 , pp. 4569-4579
    • Zhu, Q.1    Youn, H.2    Tang, J.3    Tawfik, O.4    Dennis, K.5    Terranova, P.F.6    Du, J.7    Raynal, P.8    Thrasher, J.B.9    Li, B.10
  • 8
    • 0036773284 scopus 로고    scopus 로고
    • Calcium-sensing receptor activation of Rho involves filamin and rho-guanine nucleotide exchange factor
    • DOI 10.1210/en.2002-220240
    • Pi M, Spurney RF, Tu Q, Hinson T, Quarles LD,. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Endocrinology 2002; 143: 3830-3838. (Pubitemid 35244362)
    • (2002) Endocrinology , vol.143 , Issue.10 , pp. 3830-3838
    • Min, P.I.1    Spurney, R.F.2    Qisheng, T.U.3    Hinson, T.4    Darryl Quarles, L.5
  • 9
    • 0345549484 scopus 로고    scopus 로고
    • Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway
    • DOI 10.1038/sj.onc.1206735
    • Lee SO, Lou W, Hou M, Onate SA, Gao AC,. Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway. Oncogene 2003; 22: 7981-7988. (Pubitemid 37175863)
    • (2003) Oncogene , vol.22 , Issue.39 , pp. 7981-7988
    • Lee, S.O.1    Lou, W.2    Hou, M.3    Onate, S.A.4    Gao, A.C.5
  • 11
    • 2342451911 scopus 로고    scopus 로고
    • G-protein coupled receptors in lipid rafts and caveolae: How, when and why do they go there?
    • DOI 10.1677/jme.0.0320325
    • Chini B, Parenti M,. G-protein coupled receptors in lipid rafts and caveolae: How, when and why do they go there ? J Mol Endocrinol 2004; 32: 325-338. (Pubitemid 38584639)
    • (2004) Journal of Molecular Endocrinology , vol.32 , Issue.2 , pp. 325-338
    • Chini, B.1    Parenti, M.2
  • 12
    • 32444450706 scopus 로고    scopus 로고
    • 2- adrenergic signalling in adult rat ventricular myocytes
    • DOI 10.1016/j.cardiores.2005.10.006, PII S0008636305004979
    • Calaghan S, White E,. Caveolae modulate excitation-contraction coupling and beta2-adrenergic signaling in adult rat ventricular myocytes. Cardiovasc Res 2006; 69: 816-824. (Pubitemid 43227980)
    • (2006) Cardiovascular Research , vol.69 , Issue.4 , pp. 816-824
    • Calaghan, S.1    White, E.2
  • 13
    • 0031665843 scopus 로고    scopus 로고
    • Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells
    • DOI 10.1038/2048
    • Nasu Y, Timme TL, Yang G, Bangma CH, Li L, Ren C, Park SH, DeLeon M, Wang J, Thompson TC,. Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells. Nat Med 1998; 4: 1062-1064. (Pubitemid 28417340)
    • (1998) Nature Medicine , vol.4 , Issue.9 , pp. 1062-1064
    • Nasu, Y.1    Timme, T.L.2    Yang, G.3    Bangma, C.H.4    Li, L.5    Ren, C.6    Park, S.H.7    DeLeon, M.8    Wang, J.9    Thompson, T.C.10
  • 14
    • 21644452110 scopus 로고    scopus 로고
    • Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: Genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice
    • DOI 10.1074/jbc.M501186200
    • Williams TM, Hassan GS, Li J, Cohen AW, Medina F, Frank PG, Pestell RG, Di Vizio D, Loda M, Lisanti MP,. Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: Genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice. J Biol Chem 2005; 280: 25134-25145. (Pubitemid 40934606)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.26 , pp. 25134-25145
    • Williams, T.M.1    Hassan, G.S.2    Li, J.3    Cohen, A.W.4    Medina, F.5    Frank, P.G.6    Pestell, R.G.7    Vizio, D.D.8    Loda, M.9    Lisanti, M.P.10
  • 15
    • 0032806788 scopus 로고    scopus 로고
    • Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines
    • DOI 10.1002/(SICI)1097-0045(19990901)40:4<269::AID-PROS9>3.0.CO;2-6
    • Pflug BR, Reiter RE, Nelson JB,. Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines. Prostate 1999; 40: 269-273. (Pubitemid 29398054)
    • (1999) Prostate , vol.40 , Issue.4 , pp. 269-273
    • Pflug, B.R.1    Reiter, R.E.2    Nelson, J.B.3
  • 17
    • 0035918165 scopus 로고    scopus 로고
    • Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
    • Lu ML, Schneider MC, Zheng Y, Zhang X, Richie JP,. Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. J Biol Chem 2001; 276: 13442-13451.
    • (2001) J Biol Chem , vol.276 , pp. 13442-13451
    • Lu, M.L.1    Schneider, M.C.2    Zheng, Y.3    Zhang, X.4    Richie, J.P.5
  • 19
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • DOI 10.1038/nrc1753
    • Bader AG, Kang S, Zhao L, Vogt PK,. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005; 5: 921-929. (Pubitemid 41766781)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.12 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 20
    • 0032563295 scopus 로고    scopus 로고
    • Activation of Akt/protein kinase B by G protein-coupled receptors: A role for α and βγ subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinaseγ
    • DOI 10.1074/jbc.273.30.19080
    • Murga C, Laguinge L, Wetzker R, Cuadrado A, Gutkind JS,. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol- 3-OH kinasegamma. J Biol Chem 1998; 273: 19080-19085. (Pubitemid 28366302)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.30 , pp. 19080-19085
    • Murga, C.1    Laguinge, L.2    Wetzker, R.3    Cuadrado, A.4    Gutkind, J.S.5
  • 21
    • 18144392361 scopus 로고    scopus 로고
    • Requirements for estrogen receptor α membrane localization and function
    • DOI 10.1016/j.steroids.2005.02.015
    • Evinger AJ III, Levin ER,. Requirements for estrogen receptor alpha membrane localization and function. Steroids 2005; 70: 361-363. (Pubitemid 40616033)
    • (2005) Steroids , vol.70 , Issue.5-7 SPEC. ISS. , pp. 361-363
    • Evinger III, A.J.1    Levin, E.R.2
  • 23
    • 0036793098 scopus 로고    scopus 로고
    • The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions
    • DOI 10.1210/me.2002-0070
    • Heinlein CA, Chang C,. The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol 2002; 16: 2181-2187. (Pubitemid 35155532)
    • (2002) Molecular Endocrinology , vol.16 , Issue.10 , pp. 2181-2187
    • Heinlein, C.A.1    Chang, C.2
  • 24
    • 17144364645 scopus 로고    scopus 로고
    • Signal transduction in prostate cancer progression
    • DOI 10.1042/CS20040329
    • Gioeli D,. Signal transduction in prostate cancer progression. Clin Sci (Lond) 2005; 108: 293-308. (Pubitemid 40516993)
    • (2005) Clinical Science , vol.108 , Issue.4 , pp. 293-308
    • Gioeli, D.1
  • 25
    • 5744250223 scopus 로고    scopus 로고
    • Androgen receptor cross-talk with cell signalling pathways
    • DOI 10.1080/08977190412331279908
    • Culig Z,. Androgen receptor cross-talk with cell signaling pathways. Growth Factors 2004; 22: 179-184. (Pubitemid 39377910)
    • (2004) Growth Factors , vol.22 , Issue.3 , pp. 179-184
    • Culig, Z.1
  • 26
    • 0033020144 scopus 로고    scopus 로고
    • Sex hormone-binding globulin receptor signal transduction proceeds via a G protein
    • DOI 10.1016/S0039-128X(98)00084-1, PII S0039128X98000841
    • Nakhla AM, Leonard J, Hryb DJ, Rosner W,. Sex hormone-binding globulin receptor signal transduction proceeds via a G protein. Steroids 1999; 64: 213-216. (Pubitemid 29283674)
    • (1999) Steroids , vol.64 , Issue.3 , pp. 213-216
    • Nakhla, A.M.1    Leonard, J.2    Hryb, D.J.3    Rosner, W.4
  • 27
    • 0032977457 scopus 로고    scopus 로고
    • Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane
    • DOI 10.1016/S0960-0760(99)00070-9, PII S0960076099000709
    • Rosner W, Hryb DJ, Khan MS, Nakhla AM, Romas NA,. Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane. J Steroid Biochem Mol Biol 1999; 69: 481-485. (Pubitemid 29305572)
    • (1999) Journal of Steroid Biochemistry and Molecular Biology , vol.69 , Issue.1-6 , pp. 481-485
    • Rosner, W.1    Hryb, D.J.2    Khan, M.S.3    Nakhla, A.M.4    Romas, N.A.5
  • 28
    • 0032899667 scopus 로고    scopus 로고
    • Androgen and estrogen signaling at the cell membrane via g-proteins and cyclic adenosine monophosphate
    • DOI 10.1016/S0039-128X(98)00108-1, PII S0039128X98001081
    • Rosner W, Hryb DJ, Khan MS, Nakhla AM, Romas NA,. Androgen and estrogen signaling at the cell membrane via G-proteins and cyclic adenosine monophosphate. Steroids 1999; 64: 100-106. (Pubitemid 29168593)
    • (1999) Steroids , vol.64 , Issue.1-2 , pp. 100-106
    • Rosner, W.1    Hryb, D.J.2    Khan, M.S.3    Nakhla, A.M.4    Romas, N.A.5
  • 29
    • 0029814415 scopus 로고    scopus 로고
    • Activation of the human androgen receptor through a protein kinase A signaling pathway
    • DOI 10.1074/jbc.271.33.19900
    • Nazareth LV, Weigel NL,. Activation of the human androgen receptor through a protein kinase A signaling pathway. J Biol Chem 1996; 271: 19900-19907. (Pubitemid 26281734)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.33 , pp. 19900-19907
    • Nazareth, L.V.1    Weigel, N.L.2
  • 30
    • 0033583317 scopus 로고    scopus 로고
    • Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways
    • Sadar MD,. Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways. J Biol Chem 1999; 274: 7777-7783.
    • (1999) J Biol Chem , vol.274 , pp. 7777-7783
    • Sadar, M.D.1
  • 31
    • 0029803093 scopus 로고    scopus 로고
    • Src tyrosine kinases, G(α) subunits, and H-Ras share a common membrane- anchored scaffolding protein, caveolin: Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
    • DOI 10.1074/jbc.271.46.29182
    • Li S, Couet J, Lisanti MP,. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem 1996; 271: 29182-29190. (Pubitemid 26382628)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.46 , pp. 29182-29190
    • Li, S.1    Couet, J.2    Lisanti, M.P.3
  • 32
    • 0033768873 scopus 로고    scopus 로고
    • Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin
    • Ozanne DM, Brady ME, Cook S, Gaughan L, Neal DE, Robson CN,. Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin. Mol Endocrinol 2000; 14: 1618-1626.
    • (2000) Mol Endocrinol , vol.14 , pp. 1618-1626
    • Ozanne, D.M.1    Brady, M.E.2    Cook, S.3    Gaughan, L.4    Neal, D.E.5    Robson, C.N.6
  • 33
    • 0033973279 scopus 로고    scopus 로고
    • Identification of filamin as a novel ligand for caveolin-1: Evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton
    • Stahlhut M, van Deurs B,. Identification of filamin as a novel ligand for caveolin-1: Evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton. Mol Biol Cell 2000; 11: 325-337. (Pubitemid 30075526)
    • (2000) Molecular Biology of the Cell , vol.11 , Issue.1 , pp. 325-337
    • Stahlhut, M.1    Van Deurs, B.2
  • 34
    • 0242290354 scopus 로고    scopus 로고
    • Activation of Phosphatidylinositol 3-Kinase/Akt Pathway by Androgen through Interaction of p85α, Androgen Receptor, and Src
    • DOI 10.1074/jbc.M306295200
    • Sun M, Yang L, Feldman RI, Sun XM, Bhalla KN, Jove R, Nicosia SV, Cheng JQ,. Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. J Biol Chem 2003; 278: 42992-43000. (Pubitemid 37345912)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.44 , pp. 42992-43000
    • Sun, M.1    Yang, L.2    Feldman, R.I.3    Sun, X.-M.4    Bhalla, K.N.5    Jove, R.6    Nicosia, S.V.7    Cheng, J.Q.8
  • 36
    • 7944234374 scopus 로고    scopus 로고
    • HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability
    • DOI 10.1016/j.ccr.2004.09.031, PII S1535610804003034
    • Mellinghoff IK, Vivanco I, Kwon A, Tran C, Wongvipat J, Sawyers CL,. HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability. Cancer Cell 2004; 6: 517-527. (Pubitemid 39469987)
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 517-527
    • Mellinghoff, I.K.1    Vivanco, I.2    Kwon, A.3    Tran, C.4    Wongvipat, J.5    Sawyers, C.L.6
  • 38
    • 16844386205 scopus 로고    scopus 로고
    • Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth
    • DOI 10.1158/0008-5472.CAN-04-3250
    • Cha TL, Qiu L, Chen CT, Wen Y, Hung MC,. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res 2005; 65: 2287-2295. (Pubitemid 40490138)
    • (2005) Cancer Research , vol.65 , Issue.6 , pp. 2287-2295
    • Cha, T.-L.1    Qiu, L.2    Chen, C.-T.3    Wen, Y.4    Hung, M.-C.5
  • 39
    • 21644443374 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases as drug targets in cancer
    • DOI 10.1016/j.coph.2005.03.002, PII S1471489205000834
    • Stephens L, Williams R, Hawkins P,. Phosphoinositide 3-kinases as drug targets in cancer. Curr Opin Pharmacol 2005; 5: 357-365. (Pubitemid 40932037)
    • (2005) Current Opinion in Pharmacology , vol.5 , Issue.4 SPEC. ISS. , pp. 357-365
    • Stephens, L.1    Williams, R.2    Hawkins, P.3
  • 40
    • 25444482429 scopus 로고    scopus 로고
    • Mammalian G proteins and their cell type specific functions
    • DOI 10.1152/physrev.00003.2005
    • Wettschureck N, Offermanns S,. Mammalian G proteins and their cell type specific functions. Physiol Rev 2005; 85: 1159-1204. (Pubitemid 41362268)
    • (2005) Physiological Reviews , vol.85 , Issue.4 , pp. 1159-1204
    • Wettschureck, N.1    Offermanns, S.2


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