Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells

Nature Medicine

Volumn 4, Issue 9, 1998, Pages 1062-1064

  Nasu, Yasutomo ^a   Timme, Terry L ^a   Yang, Guang ^a   Bangma, Chris H ^a   Li, Likun ^a   Ren, Chengzhen ^a   Park, Sang Hee ^a   DeLeon, Marlene ^a   Wang, Jianxiang ^a   Thompson, Timothy C ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CONTROLLED STUDY; CORRELATION FUNCTION; HORMONE RESISTANCE; HORMONE SENSITIVITY; IMMUNOBLOTTING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; TUMOR GROWTH;

ANDROGENS; ANIMALS; APOPTOSIS; CAVEOLIN 1; CAVEOLINS; DISEASE MODELS, ANIMAL; HUMANS; MALE; MEMBRANE PROTEINS; MICE; PROSTATIC NEOPLASMS; RABBITS; TESTOSTERONE; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA;

EID: 0031665843     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/2048     Document Type: Article

References (15)

1. Yang, G. et al. Elevated expression of caveolin is associated with prostate and breast cancer. Clin. Cancer Res. 8, 1873-1880 (1998).
2. Scardino, P.T. Early detection of prostate cancer. Urol. Clin. North Am. 16, 635-655 (1989).
3. Huggins, C. & Hodges, C.V. Studies on prostate cancer: effect of castration, of estrogen, and of androgen injection on serum phosphatase in metastatic carcinoma of the prostate. Cancer Res. 1, 293-397 (1941).
4. McDonnell, T.J. et al. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res. 52, 6940-6944 (1992).
5. Colombel, M. et al. Detection of the apoptosis-suppressing oncoprotein bcl-2 in hormone-refractory human prostate cancers. Am. J. Pathol. 143, 390-400 (1993).
6. Krajewaka, M. et al. Immunohistochemical analysis of bcl-2, bax, bcl-X and mcl-1 expression in prosate cancers. Am. J. Pathol. 148, 1567-1576 (1996).
7. Furuya, Y., Krajewski, S., Epstein, J.I., Reed, T.C. & Isaacs, J. Expression of bcl-2 and the progression of human and rodent prostatic cancers. Clin. Cancer Res. 2, 389-398 (1996).
8. Harder T. & Simons K. Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains. Curr. Opin. Cell. Biol. 9, 534-542 (1997).
9. Fielding, J., Bist, A. & Fielding, P. E. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc. Natl. Acad. Sci. USA 94, 3753-3758 (1997).
10. Giovannucci, E. et al. A prospective study of dietary fat and risk of prostate cancer. J. Natl. Cancer Inst. 85, 1571-1579 (1993).
11. Thompson, T.C. et al. Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer. Oncogene 10, 869-879 (1995).
12. Hall, S.J. & Thompson, T.C. Spontaneous metastatic activities but not experimental metastatic activities differentiate primary tumor-derived versus metastasis-derived mouse prostate cancer cell lines. Clin. Exp. Metastasis 15, 484-493 (1997).
13. Yang, G., Wheeler, T.M., Kattan, M.W., Scardino, P.T. & Thompson, T.C. Perineural invasion of prostate carcinoma cells is associated with reduced apoptotic index. Cancer 78, 1267-1271 (1996).
14. Gavrieli, Y., Sherman, Y. & Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell. Biol. 119, 493-501 (1992).
15. Bett, A.J., Haddara, W., Prevec, L. & Graham, F.L. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA 91, 8802-8806 (1994).