FDG PET/CT in patients with HIV

American Journal of Roentgenology

Volumn 197, Issue 2, 2011, Pages 284-294

  Davison, Jessica M ^a   Subramaniam, Rathan M ^a   Surasi, Devaki S ^a   Cooley, Timothy ^a   Mercier, Gustavo ^a   Peller, Patrick J ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

FDG PET CT; HIV

Indexed keywords

ANTIRETROVIRUS AGENT; FLUORODEOXYGLUCOSE F 18;

ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ANUS CANCER; BRAIN BIOPSY; BRAIN FUNCTION; CANCER STAGING; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; DISEASE SEVERITY; ENCEPHALITIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPROMISED PATIENT; IMMUNOSUPPRESSIVE TREATMENT; KAPOSI SARCOMA; LIPODYSTROPHY; LYMPHADENOPATHY; LYMPHOID TISSUE; MORTALITY; NONHODGKIN LYMPHOMA; PATHOGENESIS; PATIENT MONITORING; PRIORITY JOURNAL; PYREXIA IDIOPATHICA; REVIEW; SENSITIVITY AND SPECIFICITY; TOXOPLASMOSIS;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CENTRAL NERVOUS SYSTEM; DISEASE PROGRESSION; FEVER OF UNKNOWN ORIGIN; FLUORODEOXYGLUCOSE F18; HIV INFECTIONS; HUMANS; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 79960726796     PISSN: 0361803X     EISSN: 15463141     Source Type: Journal    
DOI: 10.2214/AJR.10.6332     Document Type: Review

References (66)

1. [No authors listed]. UNAIDS 2008 report on the global AIDS epidemic. Joint United Nations Programme on HIV/AIDS Website. www.unaids.org/en/ dataanalysis/epidemiology/2008reportontheglobalaidsepidemic. Published July 29, 2008. Accessed April 7, 2011
2. Quinn TC. Global burden of the HIV pandemic. Lancet 1996; 348:99-106 (Pubitemid 26234359)
3. Niu MT, Jermano JA, Reichelderfer P, Schnittman SM. Summary of the National Institutes of Health workshop on primary human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses 1993; 9:913-924 (Pubitemid 24017247)
4. Fox CH, Tenner-Racz K, Racz P, Firpo A, Pizzo PA, Fauci AS. Lymphoid germinal centers are reservoirs of human immunodeficiency virus type1 RNA. J Infect Dis 1991; 164:1051-1057
5. Pantaleo G, Graziosi C, Demarest JF, et al. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev 1994; 140:105-130 (Pubitemid 24305209)
6. Tenner-Racz K, Racz P, Gluckman JC, Popovic M. Cell-free HIV in lymph nodes of patients with AIDS and generalized lymphadenopathy. N Engl J Med 1988; 318:49-50 (Pubitemid 18025480)
7. Pantaleo G, Graziosi C, Butini L, et al. Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci U S A 1991; 88:9838-9842 (Pubitemid 21915729)
8. Bental M, Deutsch C. Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes. Magn Reson Med 1993; 29:317-326 (Pubitemid 23114497)
9. Marjanovic S, Skog S, Heiden T, Tribukait B, Nelson BD. Expression of glycolytic isoenzymes in activated human peripheral lymphocytes: cell cycle analysis using flow cytometry. Exp Cell Res 1991; 193:425-431 (Pubitemid 121005685)
10. Bakheet SM, Powe J. Benign causes of 18-FDG uptake on whole body imaging. Semin Nucl Med 1998; 28:352-358 (Pubitemid 28478048)
11. Sugawara Y, Braun DK, Kison PV, Russo JE, Zasadny KR, Wahl RL. Rapid detection of human infections with fluorine-18 fluorodeoxyglucose and positron emission tomography: preliminary results. Eur J Nucl Med 1998; 25:1238-1243 (Pubitemid 28446048)
12. Brust D, Polis M, Davey R, et al. Fluorodeoxyglucose imaging in healthy subjects with HIV infection: impact of disease stage and therapy on pattern of nodal activation. AIDS 2006; 20:985-993
13. 18F-fluoro-2-deoxyglucose positron emission tomography in healthy subjects. Anticancer Res 2001; 21:701-706
14. Scharko AM, Perlman SB, Pyzalski RW, Graziano FM, Sosman J, Pauza CD. Whole-body positron emission tomography in patients with HIV-1 infection. Lancet 2003; 362:959-961 (Pubitemid 37159292)
15. Iyengar S, Chin B, Margolick JB, Sabundayo BP, Schwartz DH. Anatomical loci of HIV-associated immune activation and association with viraemia. Lancet 2003; 362:945-950 (Pubitemid 37168049)
16. Scharko AM, Perlman SB. Hinds PW 2nd, Hanson JM, Uno H, Pauza CD. Whole body positron emission tomography imaging of simian immunodeficiency virus-infected rhesus macaques. Proc Natl Acad Sci U S A 1996; 93:6425-6430
17. Wallace M, Pyzalski R, Horejsh D, et al. Whole body positron emission tomography imaging of activated lymphoid tissues during acute simian-human immunodeficiency virus 89.6PD infection in rhesus macaques. Virology 2000; 274:255-261
18. Mbulaiteye SM, Parkin DM, Rabkin CS. Epidemiology of AIDS-related malignancies: an international perspective. Hematol Oncol Clin North Am 2003; 17:673-696 (Pubitemid 36807592)
19. Bower M, Palmieri C, Dhillon T. AIDS-related malignancies: changing epidemiology and the impact of highly active antiretroviral therapy. Curr Opin Infect Dis 2006; 19:14-19 (Pubitemid 43032434)
20. Boshoff C, Weiss R. AIDS-related malignancies. Nat Rev Cancer 2002; 2:373-382 (Pubitemid 37328950)
21. Frisch M, Biggar RJ, Engels EA, Goedert JJ. Association of cancer with AIDS-related immunosuppression in adults. JAMA 2001; 285:1736-1745 (Pubitemid 32259908)
22. Rabkin CS, Yellin F. Cancer incidence in a population with a high prevalence of infection with human immunodeficiency virus type 1. J Natl Cancer Inst 1994; 86:1711-1716 (Pubitemid 24354634)
23. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 266:1865-1869
24. Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 1996; 2:918-924 (Pubitemid 26296764)
25. Aoki Y, Tosato G. Neoplastic conditions in the context of HIV-1 infection. Curr HIV Res 2004; 2:343-349 (Pubitemid 39242964)
26. Nasti G, Talamini R, Antinori A, et al. AIDS-related Kaposi's sarcoma: evaluation of potential new prognostic factors and assessment of the AIDS Clinical Trial Group Staging System in the HAART era - the Italian Cooperative Group on AIDS and Tumors and the Italian Cohort of Patients Naive From Antiretrovirals. J Clin Oncol 2003; 21:2876-2882 (Pubitemid 46621836)
27. Krown SE, Metroka C, Wernz JC. Kaposi's sarcoma in the acquired immune deficiency syndrome: a proposal for uniform evaluation, response, and staging criteria - AIDS Clinical Trials Group Oncology Committee. J Clin Oncol 1989; 7:1201-1207 (Pubitemid 19220121)
28. Nasti G, Tirelli U. Highly active antiretroviral therapy in AIDS-associated Kaposi's sarcoma (KS): implications for the design of therapeutic trials in patients with advanced symptomatic KS. (letter) J Clin Oncol 2005; 23:2433; author reply, 2433-2434
29. Castaigne C, Tondeur M, de Wit S, Hildebrand M, Clumeck N, Dusart M. Clinical value of FDG-PET/ CT for the diagnosis of human immunodeficiency virus-associated fever of unknown origin: a retrospective study. Nucl Med Commun 2009; 30:41-47
30. O'Doherty MJ, Barrington SF, Campbell M, Lowe J, Bradbeer CS. PET scanning and the human immunodeficiency virus-positive patient. J Nucl Med 1997; 38:1575-1583 (Pubitemid 27443958)
31. Oksenhendler E, Duarte M, Soulier J, et al. Multicentric Castleman's disease in HIV infection: a clinical and pathological study of 20 patients. AIDS 1996; 10:61-67 (Pubitemid 26016404)
32. Dupin N, Diss TL, Kellam P, et al. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood 2000; 95:1406-1412 (Pubitemid 30099854)
33. Oksenhendler E, Boulanger E, Galicier L, et al. High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. Blood 2002; 99:2331-2336 (Pubitemid 34525417)
34. Hillier JC, Shaw P, Miller RF, et al. Imaging features of multicentric Castleman's disease in HIV infection. Clin Radiol 2004; 59:596-601 (Pubitemid 38950074)
35. Barker R, Kazmi F, Stebbing J, et al. FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease. Eur J Nucl Med Mol Imaging 2009; 36:648-652
36. Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 2000; 92:1500-1510
37. Subhas N, Patel PV, Pannu HK, Jacene HA, Fishman EK, Wahl RL. Imaging of pelvic malignancies with in-line FDG PET-CT: case examples and common pitfalls of FDG PET. RadioGraphics 2005; 25:1031-1043 (Pubitemid 41196938)
38. 18F] fluorodeoxyglucose positron emission tomography in carcinoma of the cervix: response and outcome. J Clin Oncol 2004; 22:2167-2171
39. Wong TZ, Jones EL, Coleman RE. Positron emission tomography with 2-deoxy-2-[(18)F]fluoro-D-glucose for evaluating local and distant disease in patients with cervical cancer. Mol Imaging Biol 2004; 6:55-62 (Pubitemid 38240359)
40. Cotter SE, Grigsby PW, Siegel BA, et al. FDG-PET/CT in the evaluation of anal carcinoma. Int J Radiat Oncol Biol Phys 2006; 65:720-725 (Pubitemid 43795859)
41. DeMario MD, Liebowitz DN. Lymphomas in the immunocompromised patient. Semin Oncol 1998; 25:492-502 (Pubitemid 28385726)
42. Gallagher B, Wang Z, Schymura MJ, Kahn A, Fordyce EJ. Cancer incidence in New York State acquired immunodeficiency syndrome patients. Am J Epidemiol 2001; 154:544-556 (Pubitemid 32867954)
43. Villringer K, Jager H, Dichgans M, et al. Differential diagnosis of CNS lesions in AIDS patients by FDG-PET. J Comput Assist Tomogr 1995; 19:532-536
44. Carbone A, Gloghini A. AIDS-related lymphomas: from pathogenesis to pathology. Br J Haematol 2005; 130:662-670 (Pubitemid 43906640)
45. Blum KA, Lozanski G, Byrd JC. Adult Burkitt leukemia and lymphoma. Blood 2004; 104:3009-3020 (Pubitemid 39507113)
46. Jhanwar YS, Straus DJ. The role of PET in lymphoma. J Nucl Med 2006; 47:1326-1334 (Pubitemid 47544887)
47. 18F-fluorodeoxyglucose positron emission tomography/computed tomography in AIDS-related Burkitt lymphoma. AIDS Patient Care STDS 2008; 22:695-700
48. Manzardo C, Del Mar Ortega M, Sued O, Garcia F, Moreno A, Miro JM. Central nervous system opportunistic infections in developed countries in the highly active antiretroviral therapy era. J Neurovirol 2005; 11[suppl 3]:72-82
49. Elder GA, Sever JL. Neurologic disorders associated with AIDS retroviral infection. Rev Infect Dis 1988; 10:286-302
50. Levy RM, Bredesen DE, Rosenblum ML, Davis RL. Central nervous system disorders in AIDS. Immunol Ser 1989; 44:371-401
51. Hoffman JM, Waskin HA, Schifter T, et al. FDGPET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS. J Nucl Med 1993; 34:567-575 (Pubitemid 23115656)
52. Offiah CE, Turnbull IW. The imaging appearances of intracranial CNS infections in adult HIV and AIDS patients. Clin Radiol 2006; 61:393-401
53. Heald AE, Hoffman JM, Bartlett JA, Waskin HA. Differentiation of central nervous system lesions in AIDS patients using positron emission tomography (PET). Int J STD AIDS 1996; 7:337-346 (Pubitemid 26330308)
54. Navia BA, Jordan BD, Price RW. The AIDS dementia complex. I. Clinical features. Ann Neurol 1986; 19:517-524 (Pubitemid 16085185)
55. Heaton RK, Grant I, Butters N, et al. The HNRC 500: neuropsychology of HIV infection at different disease stages - HIV Neurobehavioral Research Center. J Int Neuropsychol Soc 1995; 1:231-251
56. Rottenberg DA, Sidtis JJ, Strother SC, et al. Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia. J Nucl Med 1996; 37:1133-1141 (Pubitemid 26329520)
57. von Giesen HJ, Antke C, Hefter H, Wenserski F, Seitz RJ, Arendt G. Potential time course of human immunodeficiency virus type 1-associated minor motor deficits: electrophysiologic and positron emission tomography findings. Arch Neurol 2000; 57:1601-1607
58. Rottenberg DA, Moeller JR, Strother SC, et al. The metabolic pathology of the AIDS dementia complex. Ann Neurol 1987; 22:700-706 (Pubitemid 18018465)
59. Pascal S, Resnick L, Barker WW, et al. Metabolic asymmetries in asymptomatic HIV-1 seropositive subjects: relationship to disease onset and MRI findings. J Nucl Med 1991; 32:1725-1729
60. Lucignani G, Orunesu E, Cesari M, et al. FDG-PET imaging in HIV-infected subjects: relation with therapy and immunovirological variables. Eur J Nucl Med Mol Imaging 2009; 36:640-647
61. Rubio A, Martinez-Moya M, Leal M, et al. Changes in thymus volume in adult HIV-infected patients under HAART: correlation with the T-cell repopulation. Clin Exp Immunol 2002; 130:121-126
62. Hardy G, Worrell S, Hayes P, et al. Evidence of thymic reconstitution after highly active antiretroviral therapy in HIV-1 infection. HIV Med 2004; 5:67-73 (Pubitemid 38404658)
63. French MA. HIV/AIDS: immune reconstitution inflammatory syndrome - a reappraisal. Clin Infect Dis 2009; 48:101-107
64. Meintjes G, Lynen L. Prevention and treatment of the immune reconstitution inflammatory syndrome. Curr Opin HIV AIDS 2008; 3:468-476
65. Bleeker-Rovers CP, van der Ven AJ, Zomer B, et al. F-18- fluorodeoxyglucose positron emission tomography for visualization of lipodystrophy in HIV-infected patients. AIDS 2004; 18:2430-2432 (Pubitemid 40065912)
66. Goshen E, Davidson T, Avigdor A, Zwas TS, Levy I. PET/CT in the evaluation of lymphoma in patients with HIV-1 with suppressed viral loads. Clin Nucl Med 2008; 33:610-614