Fluorodeoxyglucose imaging in healthy subjects with HIV infection: Impact of disease stage and therapy on pattern of nodal activation

AIDS

Volumn 20, Issue 4, 2006, Pages 495-503

  Brust, Douglas ^a   Polis, Michael ^a   Davey, Richard ^a   Hahn, Barbara ^a   Bacharach, Stephen ^a   Whatley, Millie ^a   Fauci, Anthony S ^a   Carrasquillo, Jorge A ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b MSC 1180 ^*  (United States)

Author keywords

F 18; Fluorodeoxyglucose; HAART; HIV; PET; Positron emission tomography

Indexed keywords

ANTIRETROVIRUS AGENT; FLUORODEOXYGLUCOSE; DIAGNOSTIC AGENT; FLUORODEOXYGLUCOSE F 18; RADIOPHARMACEUTICAL AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG WITHDRAWAL; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; VIREMIA; VIRUS INHIBITION; VIRUS LOAD; VIRUS PATHOGENESIS; VIRUS REPLICATION; CASE CONTROL STUDY; EVALUATION; LYMPH NODE; METABOLISM; MIDDLE AGED; POSITRON EMISSION TOMOGRAPHY; PROSPECTIVE STUDY; SCINTISCANNING; SERODIAGNOSIS;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CASE-CONTROL STUDIES; FEMALE; FLUORODEOXYGLUCOSE F18; HIV INFECTIONS; HIV SERONEGATIVITY; HUMANS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PROSPECTIVE STUDIES; RADIOPHARMACEUTICALS;

EID: 33645421371     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.aids.0000210603.40267.29     Document Type: Article

References (37)

1. Pantaleo G, Graziosi C, Demarest JF, Cohen OJ, Vaccarezza M, Gantt K, et al. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev 1994; 140:105-130.
2. Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD. HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science 1996; 271:1582-1586.
3. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, et al. Viral dynamics in human-immunodeficiency-virus type-1 infection. Nature 1995; 373:117-122.
4. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995; 373:123-126.
5. Silvestri G, Feinberg MB. Turnover of lymphocytes and conceptual paradigms in HIV infection. J Clin Invest 2003; 112:821-824.
6. Moanna A, Dunham R, Paiardini M, Silvestri G. CD4+ T-cell depletion in HIV infection: killed by friendly fire? Curr HIV/AIDS Rep 2005; 2:16-23.
7. Zaunders JJ, Cunningham PH, Kelleher AD, Kaufmann GR, Jaramillo AB, Wright R, et al. Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: Partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia. J Infect Dis 1999; 180:320-329.
8. Fleury S, Pantaleo G. T cell regeneration in HIV-infected subjects under highly active antiretroviral therapy (Review). Int J Mol Med 1999; 4:91-97.
9. Stellbrink HJ, Zoller B, Fenner T, Lichtenberg G, van Lunzen J, Albrecht H, et al. Rapid plasma virus and CD4+ T-cell turnover in HIV-1 infection: Evidence for an only transient interruption by treatment. AIDS 1996; 10:849-857.
10. Wood GS. The immunohistology of lymph nodes in HIV infection: a review. Prog AIDS Pathol 1990; 2:25-32.
11. Smith PD, Meng G, Salazar-Gonzalez JF, Shaw GM. Macrophage HIV-1 infection and the gastrointestinal tract reservoir. J Leukocyte Biol 2003; 74:642-649.
12. Bissel SJ, Wiley CA. Human immunodeficiency virus infection of the brain: Pitfalls in evaluating infected/affected cell populations. Brain Pathol 2004; 14:97-108.
13. Muciaccia B, Uccini S, Filippini A, Ziparo E, Paraire F, Baroni CD, et al. Presence and cellular distribution of HIV in the testes of seropositive subjects: an evaluation by in situ PCR hybridization. FASEB J 1998; 12:151-163.
14. Pomerantz RJ. Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. Biomed Pharmacother 2001; 55:7-15.
15. Scharko AM, Perlman SB, Hinds PW, Hanson JM, Uno H, Pauza CD. Whole body positron emission tomography imaging of simian immunodeficiency virus-infected rhesus macaques. Proc Natl Acad Sci USA 1996; 93:6425-6430.
16. Scharko AM, Perlman SB, Pyzalski RW, Graziano FM, Sosman J, Pauza CD. Whole-body positron emission tomography in patients with HIV-1 infection. Lancet 2003; 362:959-961.
17. Iyengar S, Chin B, Margolick JB, Sabundayo BP, Schwartz DH. Anatomical loci of HIV-associated immune activation and association with viraemia. Lancet 2003; 362:945-950.
18. Migueles SA, Sabbaghian MS, Shupert WL, Bettinotti MP, Marincola FM, Martino L, et al. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci USA 2000; 97:2709-2714.
19. Zasadny KR, Wahl RL. Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction. Radiology 1993; 189:847-850.
20. Akhurst T, Ng VV, Larson SM, O'Donoghue JA, O'Neel J, Erdi Y, et al. Tumor burden assessment with positron emission tomography. Clin Positron Imaging 2000; 3:57-65.
21. Mayer D, Bednarczyk EM. Interaction of colony-stimulating factors and fluorodeoxyglucose F-18 positron emission tomography. Ann Pharmacother 2002; 36:1796-1799.
22. Pantaleo G, Graziosi C, Butini L, Pizzo PA, Schnittman SM, Kotler DP, et al. Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 1991; 88:9838-9842.
23. Bental M, Deutsch C. Metabolic changes in activated T-cells - an NMR study of human peripheral-blood lymphocytes. Magnetic Resonance Med 1993; 29:317-326.
24. Brand KA, Hermfisse U. Aerobic glycolysis by proliferating cells: A protective strategy against reactive oxygen species. FASEB J 1997; 11:388-395.
25. Zhuang HM, Alavi A. 18-fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation. Semin Nucl Med 2002; 32:47-59.
26. Kubota R, Kubota K, Yamada S, Tada M, Ido T, Tamahashi N. Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18- fluorodeoxyglucose uptake. J Nucl Med 1994; 35:104-112.
27. Nowak M, Carrasquillo J, Yarboro C, Bacharach SL, Whatley M, Valencia X, et al. A pilot study of F-18FDG positron emission tomography(FDG-PET) to assess the distribution of activated lymphocytes in systemic lupus erythematosus (SLE). Arthritis Rheumatism 2002; 46:S25.
28. O'Doherty MJ, Barrington SF, Campbell M, Lowe J, Bradbeer CS. PET scanning and the human immunodeficiency virus-positive patient. J Nucl Med 1997; 38:1575-1583.
29. Dyrhol-Riise AM, Voltersvik P, Olofsson J, Asjo B. Activation of CD8 T cells normalizes and correlates with the level of infectious provirus in tonsils during highly active antiretroviral therapy in early HIV-1 infection. AIDS 1999; 13:2365-2376.
30. Vargas PA, Mauad T, Bohm GM, Saldiva PHN, Almeida OP. Parotid gland involvement in advanced AIDS. Oral Dis 2003; 9:55-61.
31. Kazi S, Cohen PR, Williams F, Schempp R, Reveille JD. The diffuse infiltrative lymphocytosis syndrome: Clinical and immunogenetic features in 35 patients. AIDS 1996; 10:385-391.
32. Pomerantz RJ. Reservoirs, sanctuaries, and residual disease: The hiding spots of HIV-1. HIV Clinical Trials 2003; 4:137-143.
33. Lambotte O, Deiva K, Tardieu M. HIV-1 persistence, viral reservoir, and the central nervous system in the HAART era. Brain Pathol 2003; 13:95-103.
34. Davey RT, Bhat N, Yoder C, Chun TW, Metcalf JA, Dewar R, et al. HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc Natl Acad Sci USA 1999; 96:15109-15114.
35. Orenstein JM, Bhat N, Yoder C, Fox C, Polis MA, Metcalf JA, et al. Rapid activation of lymph nodes and mononuclear cell HIV expression upon interrupting highly active antiretroviral therapy in patients after prolonged viral suppression. AIDS 2000; 14:1709-1715.
36. Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan CW, et al. HIV-specific CD8(+) T cell proliferation is coupled to perforin expression and is maintained in non-progressors. Nat Immunol 2002; 3:1061-1068.
37. Gupta NC, Graeber GM, Bishop HA. Comparative efficacy of positron emission tomography with fluorodeoxyglucose in evaluation of small (< 1 cm), intermediate (1 to 3 cm), and large (> 3 cm) lymph node lesions. Chest 2000; 117:773-778.