Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice

Hepatology

Volumn 54, Issue 2, 2011, Pages 697-706

  Zhang, Ji ^a   Handy, Diane E ^b   Wang, Yufang ^c   Bouchard, Guylaine ^a,e,f   Selhub, Jacob ^d   Loscalzo, Joseph ^b   Carey, Martin C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d TUFTS UNIVERSITY   (United States)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

^f UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CHOLESTEROL; CHOLIC ACID; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; CYSTEINE; CYTIDINE TRIPHOSPHATE; FOLIC ACID; GLYCINE METHYLTRANSFERASE; GUANIDINOACETATE METHYLTRANSFERASE; HOMOCYSTEINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CHOLELITHIASIS; CHOLESTEROL CHOLELITHOGENESIS; CHOLESTEROL DIET; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GALLSTONE; GENE EXPRESSION; HYPERHOMOCYSTEINEMIA; LIPID DIET; LITHOGENIC DIET; LIVER HOMOGENATE; MALE; METHYLATION; MOUSE; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; REVIEW; SULFATION; SULFURATION; UPREGULATION;

ANIMALS; CHOLELITHIASIS; CHOLESTEROL; HYPERHOMOCYSTEINEMIA; LIVER; METHYLATION; MICE; PHOSPHATIDYLETHANOLAMINES;

EID: 79960716241     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24428     Document Type: Review

References (49)

1. Bortnichak EA, Freeman DH, Ostfeld AM, Castelli WP, Kannel WB, Feinleib M, et al. The association between cholesterol cholelithiasis and coronary heart disease in Framingham, Massachusetts. Am J Epidemiol 1985; 121: 19-30.
2. Ruhl CE, Everhart JE. Gallstone disease is associated with increased mortality in the United States. Gastroenterology 2011; 140: 508-516.
3. Paigen B, Carey MC. Gallstones. In: King RA, Rotter JI, Motulsky AG, eds. The genetic basis of common disease. 2nd ed. London: Oxford University Press; 2002: 298-335.
4. Biddinger SB, Haas JT, Yu BB, Bezy O, Jing E, Zhang W, et al. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 2008; 14: 778-782.
5. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, et al. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 2008; 7: 125-134.
6. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999; 19: 217-246.
7. Carey MC, Fennelly JJ, FitzGerald O. Homocystinuria: II. Subnormal serum folate levels, increased folate clearance and effects of folic acid therapy. Am J Med 1968; 45: 26-31.
8. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991; 324: 1149-1155.
9. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998; 338: 1042-1050.
10. Mattson MP, Kruman II, Duan W. Folic acid and homocysteine in age-related disease. Ageing Res Rev 2002; 1: 95-111.
11. Kim DJ, Koh J-M, Lee O, Kim NJ, Lee Y-S, Kim YS, et al. Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone 2006; 39: 582-590.
12. Sakuta H, Suzuki T. Plasma total homocysteine and gallstone in middle-aged Japanese men. J Gastroenterol 2005; 40: 1061-1064.
13. Worthington HV, Hunt LP, McCloy RF, Ubbink JB, Braganza JM. Dietary antioxidant lack, impaired hepatic glutathione reserve, and cholesterol gallstones. Clin Chim Acta 2004; 349: 157-165.
14. LaMont JT, Carey MC. Cholesterol gallstone formation. 2. Pathobiology and pathomechanics. Prog Liver Dis 1992; 10: 165-191.
15. Shaffer EA, Small DM. Biliary lipid secretion in cholesterol gallstone disease. The effect of cholecystectomy and obesity. J Clin Invest 1977; 59: 828-840.
16. Carey MC, LaMont JT. Cholesterol gallstone formation. 1. Physical-chemistry of bile and biliary lipid secretion. Prog Liver Dis 1992; 10: 139-163.
17. Hay DW, Cahalane MJ, Timofeyeva N, Carey MC. Molecular species of lecithins in human gallbladder bile. J Lipid Res 1993; 34: 759-768.
18. Moschetta A, Xu F, Hagey LR, van Berge-Henegouwen GP, van Erpecum KJ, Brouwers JF, et al. A phylogenetic survey of biliary lipids in vertebrates. J Lipid Res 2005; 46: 2221-2232.
19. Kennedy EP, Weiss SB. The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem 1956; 222: 193-214.
20. Vance DE, Walkey CJ, Cui Z. Phosphatidylethanolamine N-methyltransferase from liver. Biochim Biophys Acta 1997; 1348: 142-150.
21. Sundler R, Åkesson B. Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates. J Biol Chem 1975; 250: 3359-3367.
22. Wang DQ, Lammert F, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice. Pathophysiology of biliary lipid secretion. J Lipid Res 1999; 40: 2066-2079.
23. Horne DW, Patterson D. Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates. Clin Chem 1988; 34: 2357-2359.
24. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987; 422: 43-52.
25. Wang DQ, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile. J Lipid Res 1997; 38: 1395-1411.
26. Maurer KJ, Ihrig MM, Rogers AB, Ng V, Bouchard G, Leonard MR, et al. Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology 2005; 128: 1023-1033.
27. Turley SD, Dietschy JM. Re-evaluation of the 3α-hydroxysteroid dehydrogenase assay for total bile acids in bile. J Lipid Res 1978; 19: 924-928.
28. Bartlett GR. Phosphorus assay in column chromatography. J Biol Chem 1959; 234: 466-468.
29. Jeske DJ, Dietschy JM. Regulation of rates of cholesterol synthesis in vivo in the liver and carcass of the rat measured using [3H]water. J Lipid Res 1980; 21: 364-376.
30. Vercaemst R, Union A, Rosseneu M. Separation and quantitation of free cholesterol and cholesteryl esters in a macrophage cell line by high-performance liquid chromatography. J Chromatogr 1989; 494: 43-52.
31. Carey MC. Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res 1978; 19: 945-955.
32. Bottiglieri T. Isocratic high performance liquid chromatographic analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues: the effect of exposure to nitrous oxide. Biomed Chromatogr 1990; 4: 239-241.
33. Verma A, Ahmed HA, Davis T, Jazrawi RP, Northfield TC. Demonstration and partial characterisation of phospholipid methyltransferase activity in bile canalicular membrane from hamster liver. J Hepatol 1999; 31: 852-859.
34. Yao Z, Jamil H, Vance DE. Choline deficiency causes translocation of CTP:phosphocholine cytidylyltransferase from cytosol to endoplasmic reticulum in rat liver. J Biol Chem 1990; 265: 4326-4331.
35. Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol 2004; 51: 405-413.
36. Rowling MJ, McMullen MH, Chipman DC, Schalinske KL. Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats. J Nutr 2002; 132: 2545-2550.
37. Vance DE, Li Z, Jacobs RL. Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology. J Biol Chem 2007; 282: 33237-33241.
38. Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE. Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem 2003; 278: 5952-5955.
39. Verkade HJ, Havinga R, Shields DJ, Wolters H, Bloks VW, Kuipers F, et al. The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion. J Lipid Res 2007; 48: 2058-2064.
40. Walkey CJ, Yu L, Agellon LB, Vance DE. Biochemical and evolutionary significance of phospholipid methylation. J Biol Chem 1998; 273: 27043-27046.
41. Lyons MA, Wittenburg H. Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genes. Gastroenterology 2006; 131: 1943-1970.
42. Wang DQ, Lammert F, Cohen DE, Paigen B, Carey MC. Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis. Am J Physiol 1999; 276: G751-G760.
43. Ventura P, Rosa MC, Abbati G, Marchini S, Grandone E, Vergura P, et al. Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics. Liver Int 2005; 25: 49-56.
44. Jacobs RL, Stead LM, Devlin C, Tabas I, Brosnan ME, Brosnan JT, et al. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem 2005; 280: 28299-28305.
45. Vance DE, Ridgway ND. The methylation of phosphatidylethanolamine. Prog Lipid Res 1988; 27: 19.
46. Sehayek E, Wang R, Ono JG, Zinchuk VS, Duncan EM, Shefer S, et al. Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. J Lipid Res 2003; 44: 1605-1613.
47. Reed MC, Nijhout HF, Neuhouser ML, Gregory JF, Shane B, James SJ, et al. A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr 2006; 136: 2653-2661.
48. Bennion LJ, Knowler WC, Mott DM, Spagnola AM, Bennett PH. Development of lithogenic bile during puberty in Pima Indians. N Engl J Med 1979; 300: 873-876.
49. Von Bergmann K, Becker M, Leiss O. Biliary cholesterol saturation in non-obese women and non-obese men before and after puberty. Eur J Clin Invest 1986; 16: 531-535.