Demonstration and partial characterisation of phospholipid methyltransferase activity in bile canalicular membrane from hamster liver

Journal of Hepatology

Volumn 31, Issue 5, 1999, Pages 852-859

  Verma, Ashwin ^a   Ahmed, Hafez A ^a   Davis, Theresa ^a   Jazrawi, Riadh P ^a   Northfield, Timothy C ^b  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Methyltransferase; Ph ospholipid transport; Phosphatidylcholine; Phosphatidylethanolamine; SAMe

Indexed keywords

METHYLTRANSFERASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; S ADENOSYLMETHIONINE;

ANIMAL TISSUE; ARTICLE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYMOLOGY; HAMSTER; INTRAHEPATIC BILE DUCT; LIVER MICROSOME; LIVER MITOCHONDRION; MICHAELIS CONSTANT; NONHUMAN; PH; PHOSPHOLIPID METHYLATION; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL;

EID: 0032722778     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80286-4     Document Type: Article

References (34)

1. Sundler R, Akesson B. Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates. J Biol Chem. 250:1975;3359-3367.
2. Audubert F, Vance DE. Pitfalls and problems in studies on the methylation of phosphatidylethanolamine. J Biol Chem. 258:1983;10695-10701.
3. Ridgway ND, Vance DE. Purification of phosphatidylethanolamine N-methyltransferase from rat liver. J Biol Chem. 262:1987;17231-17239.
4. Cui Z, Vance JE, Chen MH, Voelker DR, Vance DE. Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. J Biol Chem. 268:1993;16655-16663.
5. Ridgway ND. Vance DE. Phosphatidylcholine Metabolism. 1989;103-120 CRC Press, Boca Raton, FL.
6. Vance JE. Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem. 265:1990;7248-7256.
7. Walkey CJ, Cui Z, Agellon LB, Vance DE. Characterization of the murine phosphatidylethanolamine N-methyltransferase-2 gene. J Lipid Res. 37:1996;2341-2350.
8. Walkey CJ, Donohue LR, Bronson R, Agellon LB, Vance DE. Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase. Proc Natl Acad Sci USA. 94:1997;12880-12885.
9. Ahmed HA, Jazrawi RP, Goggin PM, Dormandy J, Northfield TC. Intrahepatic biliary cholesterol and phospholipid transport in humans: effect of obesity and cholesterol cholelithiasis. J Lipid Res. 36:1995;2562-2573.
10. Graham J, Ahmed H, Northfield TC. Unidirectional pathway for vesicular cholesterol transport. Trends in Bile Acid Research. 1989;177-187 Kluwer Academic Publishers, Dordrecht, The Netherlands.
11. Ruetz S, Gros P. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell. 77:1994;1071-1081.
12. Berr F, Meier PJ, Stieger B. Evidence for the presence of a phosphatidylcholine translocator in isolated rat liver canalicular plasma membrane vesicles. J Biol Chem. 268:1993;3976-3979.
13. Cohen DE, Angelico M, Carey MC. Structural alterations in lecithin-cholesterol vesicles following interactions with monomeric and micellar bile salts: physical-chemical basis for subselection of biliary lecithin species and aggregative states of biliary lipids during bile formation. J Lipid Res. 31:1990;55-70.
14. Berman HM, Gram W, Spirtes MA. An improved, reproducible method for preparing rat liver plasma cell membranes in buffered isotonic sucrose. Biochim Biophys Acta. 183:1969;10-18.
15. Wisher MH, Evans WH. Functional polarity of the rat hepatocyte surface membrane. Isolation and characterization of plasmamembrane subfractions from the blood-sinusoidal, bile-canalicular and contiguous surfaces of the hepatocyte. Biochem J. 146:1975;375-388.
16. Lowry OH, Rosebrongh NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 193:1951;265-275.
17. Engstrom L. Studies on calf intestinal alkaline phosphatase.1. Chromatographic purification, microheterogeneity and some other properties of the purified enzyme. Biochim Biophys Acta. 52:1961;36-48.
18. Avruch J, Wallach DF. Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells. Biochim Biophys Acta. 233:1971;334-347.
19. Williams CH, Kamin H. Microsomal triphosphopyridine nucleotide cytochrome C reductase of liver. J Biol Chem. 237:1962;587-595.
20. Mackler B, Collip P, Duncan H, Appaji Rao M, Heunnekens F. An electron transport particle from yeast, purification and properties. J Biol Chem. 237:1962;2968-2974.
21. Vance DE, Schneider WJ. Conversion of phosphatidylethanolamine to phosphatidylcholine. Methods Enzymol. 71:1991;581-588.
22. Weibel ER, Staubli W, Gnagi HR, Hess FA. Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver. J Cell Biol. 42:1969;68-91.
23. Ridgway ND, Vance DE. Kinetic mechanism of phosphatidyle-thanolamine N-methyltransferase. J Biol Chem. 263:1988;16864-16871.
24. Yousef IM, Bloxam DL, Phillips MJ, Fisher MM. Liver cell plasma membrane lipids and the origin of biliary phospholipid. Can J Biochem. 53:1975;989-997.
25. Reitz RC, Mead DJ, Bjur RA, Greenhouse AH, Welch WH Jr. Phosphatidylethanolamine N-methyltransferase in human red blood cell membrane preparations. Kinetic mechanism. J Biol Chem. 264:1989;8097-8106.
26. Schneider WJ, Vance DE. Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. J Biol Chem. 254:1979;3886-3891.
27. Houweling M, Cui Z, Tessitore L, Vance DE. Induction of hepatocyte proliferation after partial hepatectomy is accompanied by a markedly reduced expression of phosphatidylethanolamine N-methyltransferase-2. Biochim Biophys Acta. 1346:1997;1-9.
28. Cui Z, Shen Y, Vance DE. Inverse correlation between expression of phosphatidylethanolamine N-methyltransferase-2 and growth of perinatal rat livers. Biochim Biophys Acta. 1346:1997;10-16.
29. Tessitore L, Cui Z, Vance DE. Transient activation of phosphatidylethanolamine N-methyltransferase-2 and activation of cytidine triphosphate: phosphocholine cytidyltransferase during nonneoplastic liver growth. Biochem J. 322:1997;151-154.
30. Houweling M, Cui Z, Vance DE. Expression of phosphatidylethanolamine N-methyltransferase-2 cannot compensate for an impaired CDP-choline pathway in mutant Chinese hamster ovary cells. J Biol Chem. 270:1995;16277-16282.
31. Cui Z, Houweling M, Vance DE. Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase. Biochem J. 312:1995;939-945.
32. Cohen DE, Leonard MR, Carey MC. In vitro evidence that phospholipid secretion into bile may be coordinated intracellularly by the combined actions of bile salts and the specific phosphatidylcholine transfer protein of liver. Biochemistry. 33:1994;9975-9980.
33. Crawford AR, Smith AJ, Hatch VC, Oude Elferink RP, Borst P, Crawford JM. Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. J Clin Invest. 100:1997;2562-2567.
34. Frezza M, Terpin M. The use of S-adenosyl methionine in the treatment of cholestatic disorders: a meta analysis of clinical trials. Drug Investigation. 4:(Suppl 4):1992;101-108.