Posttranslational modification of differentially expressed mitochondrial proteins in the retina during early experimental autoimmune uveitis

Molecular Vision

Volumn 17, Issue , 2011, Pages 1814-1821

  Saraswathy, Sindhu ^a   Rao, Narsing A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITATE HYDRATASE; ALPHA CRYSTALLIN; BETA CRYSTALLIN; FREUND ADJUVANT; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN 70; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; LAMIN 1; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SYNTAXIN BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE UVEITIS; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN METHYLATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; RETINA MITOCHONDRION; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION; UVEITIS;

AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; EYE PROTEINS; FREUND'S ADJUVANT; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; MICE; MICE, INBRED STRAINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RETINA; RETINOL-BINDING PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TWO-DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; UVEITIS;

EID: 79960708329     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Rao NA, Saraswathy S, Wu GS, Katselis GS, Wawrousek EF, Bhat S. Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis. Invest Ophthalmol Vis Sci 2008; 49:1161-71.
2. Agarwal RK, Caspi RR. Rodent models of experimental autoimmune uveitis. Methods Mol Med 2004; 102:395-419.
3. Saraswathy S, Rao NA. Mitochondrial proteomics in experimental autoimmune uveitis oxidative stress. Invest Ophthalmol Vis Sci 2009; 50:5559-66.
4. Khurana RN, Parikh JG, Saraswathy S, Wu G-S, Rao NA. Mitochondrial oxidative DNA damage in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 2008; 49:3299-304.
5. Rajendram R, Saraswathy S, Rao NA. Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis. Br J Ophthalmol 2007; 91:531-7.
6. Wu YT, Wu SB, Lee WY, Wei YH. Mitochondrial respiratory dysfunction-elicited oxidative stress and posttranslational protein modification in mitochondrial diseases. Ann N Y Acad Sci 2010; 1201:147-56.
7. Chen X, Li J, Hou J, Xie Z, Yang F. Mammalian mitochondrial proteomics: insights into mitochondrial functions and mitochondria-related diseases. Expert Rev Proteomics 2010; 7:333-45.
8. Suh SK, Hood BL, Kim BJ, Conrads TP, Veenstra TD, Song BJ. Identification of oxidized mitochondrial proteins in alcohol-exposed human hepatoma cells and mouse liver. Proteomics 2004; 4:3401-12.
9. Sultana R, Perluigi M, Butterfield DA. Proteomics identification of oxidatively modified proteins in brain. Methods Mol Biol 2009; 564:291-301.
10. Gibson BW. The human mitochondrial proteome: oxidative stress, protein modifications and oxidative phosphorylation. Int J Biochem Cell Biol 2005; 37:927-34.
11. Moon KH, Hood BL, Mukhopadhyay P, Rajesh M, Abdelmegeed MA, Kwon YI, Conrads TP, Veenstra TD, Song BJ, Pacher P. Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion. Gastroenterology 2008; 135:1344-57.
12. Jay D, Hitomi H, Griendling KK. Oxidative stress and diabetic cardiovascular complications. Free Radic Biol Med 2006; 40:183-92.
13. Hipkiss AR. Accumulation of altered proteins and ageing: causes and effects. Exp Gerontol 2006; 41:464-73.
14. Saris NE, Eriksson KO. Mitochondrial dysfunction in ischaemia-reperfusion. Acta Anaesthesiol Scand Suppl 1995; 107:171-6.
15. Yaung J, Jin M, Barron E, Spee C, Wawrousek EF, Kannan R, Hinton DR. alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis 2007; 13:566-77.
16. Saraswathy S, Rao NA. Photoreceptor mitochondrial oxidative stress in experimental autoimmune uveitis. Ophthalmic Res 2008; 40:160-4.
17. Ruiz-Romero C, Blanco FJ. Mitochondrial proteomics and its application in biomedical research. Mol Biosyst 2009; 5:1130-42.
18. Richter C. Oxidative stress, mitochondria, and apoptosis. Restor Neurol Neurosci 1998; 12:59-62.
19. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281:1309-12.
20. Susin SA, Zamzami N, Kroemer G. Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta 1998; 1366:151-65.
21. Mignotte B, Vayssiere JL. Mitochondria and apoptosis. Eur J Biochem 1998; 252:1-15.
22. Mizuno Y, Yoshino H, Ikebe S, Hattori N, Kobayashi T, Shimoda-Matsubayashi S, Matsumine H, Kondo T. Mitochondrial dysfunction in Parkinson's disease. Ann Neurol 1998; 44:S99-109.
23. Jarrett SG, Lin H, Godley BF, Boulton ME. Mitochondrial DNA damage and its potential role in retinal degeneration. Prog Retin Eye Res 2008; 27:596-607.
24. Lopez MF, Melov S. Applied proteomics: mitochondrial proteins and effect on function. Circ Res 2002; 90:380-9.
25. Smith DJ. Mitochondrial dysfunction in mouse models of Parkinson's disease revealed by transcriptomics and proteomics. J Bioenerg Biomembr 2009; 41:487-91.
26. Chin MH, Qian WJ, Wang H, Petyuk VA, Bloom JS, Sforza DM, Lacan G, Liu D, Khan AH, Cantor RM, Bigelow DJ, Melega WP, Camp DG 2nd, Smith RD, Smith DJ. Mitochondrial dysfunction, oxidative stress, and apoptosis revealed by proteomic and transcriptomic analyses of the striata in two mouse models of Parkinson's disease. J Proteome Res 2008; 7:666-77.
27. Bailey SM, Landar A, Darley-Usmar V. Mitochondrial proteomics in free radical research. Free Radic Biol Med 2005; 38:175-88.
28. Venkatraman A, Landar A, Davis AJ, Ulasova E, Page G, Murphy MP, Darley-Usmar V, Bailey SM. Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption. Am J Physiol Gastrointest Liver Physiol 2004; 286:G521-7.
29. Opii WO, Nukala VN, Sultana R, Pandya JD, Day KM, Merchant ML, Klein JB, Sullivan PG, Butterfield DA. Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury. J Neurotrauma 2007; 24:772-89.
30. Stadtman ER, Moskovitz J, Levine RL. Oxidation of methionine residues of proteins: biological consequences. Antioxid Redox Signal 2003; 5:577-82.
31. Lin TK, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RA, Murphy MP. Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem 2002; 277:17048-56.
32. Andringa KK, Bailey SM. Detection of protein thiols in mitochondrial oxidative phosphorylation complexes and associated proteins. Methods Enzymol 2010; 474:83-108.
33. Butterfield DA, Perluigi M, Sultana R. Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics. Eur J Pharmacol 2006; 545:39-50.
34. Grune T, Jung T, Merker K, Davies KJ. Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int J Biochem Cell Biol 2004; 36:2519-30.
35. Yarian CS, Rebrin I, Sohal RS. Aconitase and ATP synthase are targets of malondialdehyde modification and undergo an age-related decrease in activity in mouse heart mitochondria. Biochem Biophys Res Commun 2005; 330:151-6.
36. Bailey SM, Patel VB, Young TA, Asayama K, Cunningham CC. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcohol Clin Exp Res 2001; 25:726-33.