The kynurenine pathway in major depression: Haplotype analysis of three related functional candidate genes

Psychiatry Research

Volumn 188, Issue 3, 2011, Pages 355-360

  Claes, Stephan ^a   Myint, Aye Mu ^b   Domschke, Katharina ^c   Del Favero, Jurgen ^d   Entrich, Kathrin ^c   Engelborghs, Sebastiaan ^e,f   De Deyn, Peter ^e,f   Mueller, Norbert ^b   Baune, Bernhard ^c   Rothermundt, Matthias ^c  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF ANTWERP   (Belgium)

^e Hoge Beuken Hospital   (Belgium)

^f UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Depression; Kynurenic acid; Kynurenine; Kynurenine amino transferases

Indexed keywords

KYNURENINE; KYNURENINE 3 MONOOXYGENASE; KYNURENINE AMINOTRANSFERASE; KYNURENINE AMINOTRANSFERASE 3; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIPOLAR DEPRESSION; CAUCASIAN; CONTROLLED STUDY; DISEASE ASSOCIATION; ENERGY METABOLISM; ETHNICITY; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; KYNURENINE 3 MONOOXYGENASE GENE; KYNURENINE AMINOTRANSFERASE 3 GENE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRYPTOPHAN HYDROXYLASE 2 GENE;

ADULT; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; KYNURENINE; KYNURENINE 3-MONOOXYGENASE; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; SIGNAL TRANSDUCTION; TRANSAMINASES; TRYPTOPHAN HYDROXYLASE;

EID: 79960698937     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2011.03.012     Document Type: Article

References (45)

1. Anisman H., Ravindran A.V., Griffiths J., Merali Z. Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Molecular Psychiatry 1999, 4:182-188.
2. Baune B.T., Hohoff C., Berger K., Neumann A., Mortensen S., Roehrs T., Deckert J., Arolt V., Domschke K. Association of the COMT val158met variant with antidepressant treatment response in major depression. Neuropsychopharmacology 2008, 33:924-932.
3. Baune B.T., Hohoff C., Roehrs T., Deckert J., Arolt V., Domschke K. Serotonin receptor 1A-1019C/G variant: Impact on antidepressant pharmacoresponse in melancholic depression?. Neuroscience Letters 2008, 436:111-115.
4. Bender D.A., Mccreanor G.M. Kynurenine hydroxylase: a potential rate-limiting enzyme in tryptophan metabolism. Biochemical Society Transactions 1985, 13:441-443.
5. Carlin J.M., Borden E.C., Sondel P.M., Byrne G.I. Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell cultures. Journal of Immunology 1987, 139:2414-2418.
6. Carlin J.M., Borden E.C., Sondel P.M., Byrne G.I. Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes. Journal of Leukocyte Biology 1989, 45:29-34.
7. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301(5631):386-389.
8. Chiarugi A., Calvani M., Meli E., Traggiai E., Moroni F. Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages. Journal of Neuroimmunology 2001, 120:190-198.
9. Claes S., Villafuerte S., Forsgren T., Sluijs S., Del-Favero J., Adolfsson R., Van B.C. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. Biological Psychiatry 2003, 54(9):867-872.
10. Connor T.J., Leonard B.E. Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Science 1998, 62(7):583-606.
11. Domschke K., Dannlowski U., Ohrmann P., Lawford B., Bauer J., Kugel H., Heindel W., Young R., Morris P., Arolt V., Deckert J., Suslow T., Baune B.T. Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression. European Neuropsychopharmacology 2008, 18:751-759.
12. Domschke K., Hohoff C., Mortensen L., Roehrs T., Deckert J., Arolt V., Baune B. Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression. Progress in Neuropsychopharmacology & Biological Psychiatry 2008, 32:224-228.
13. Garriock H.A., Allen J.J., Delgado P., Nahaz Z., Kling M.A., Carpenter L., Burke M., Burke W., Schwartz T., Marangell L.B., Husain M., Erickson R.P., Moreno F.A. Lack of association of TPH2 exon XI polymorphisms with major depression and treatment resistance. Molecular Psychiatry 2005, 10(11):976-977.
14. Han Q., Robinson H., Cai T., Tagle D.A., Li J. Biochemical and structural properties of mouse kynurenine aminotransferase III. Molecular and Cellular Biology 2009, 29(3):784-793.
15. Hayaishi O. Biochemical and Medical Aspects of Tryptophan Metabolism 1980, Elsevier/North-Holland Biomedical Press, Amsterdam.
16. Heyes M.P., Saito K., Major E.O., Milstien S., Markey S.P., Vickers J.H. A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Brain 1993, 116(Pt 6):1425-1450.
17. Kendler K.S., Gatz M., Gardner C.O., Pedersen N.L. A Swedish national twin study of lifetime major depression. The American Journal of Psychiatry 2006, 163(1):109-114.
18. Kim J.P., Choi D.W. Quinolinate neurotoxicity in cortical cell culture. Neuroscience 1987, 23:423-432.
19. Kim Y.K., Suh I.B., Kim H., Han C.S., Lim C.S., Choi S.H., Licinio J. The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs. Molecular Psychiatry 2002, 7:1107-1114.
20. Lanquillon S., Krieg J.C., Bening-Abu-Shach U., Vedder H. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 2000, 22:370-379.
21. Lopez-Leon S., Janssens A.C., Gonzalez-Zuloeta Ladd A.M., Del-Favero J., Claes S.J., Oostra B.A., van Duijn C.M. Meta-analyses of genetic studies on major depressive disorder. Molecular Psychiatry 2008, 13(8):772-785.
22. Matthes S., Mosienko V., Bashammakh S., Alenina N., Bader M. Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology 2010, 85(2):95-109.
23. Mellor A.L., Munn D.H. Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?. Immunology Today 1999, 20:469-473.
24. Mikova O., Yakimova R., Bosmans E., Kenis G., Maes M. Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis. European Neuropsychopharmacology 2001, 11:203-208.
25. Muglia P., Tozzi F., Galwey N.W., Francks C., Upmanyu R., Kong X.Q., Antoniades A., Domenici E., Perry J., Rothen S., Vandeleur C.L., Mooser V., Waeber G., Vollenweider P., Preisig M., Lucae S., Muller-Myhsok B., Holsboer F., Middleton L.T., Roses A.D. Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Molecular Psychiatry 2010, 15(6):589-601.
26. Musso T., Gusella G.L., Brooks A., Longo D.L., Varesio L. Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes. Blood 1994, 83:1408-1411.
27. Myint A.M., Kim Y.K. Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Medical Hypotheses 2003, 61:519-525.
28. Myint A.M., Leonard B.E., Steinbusch H.W., Kim Y.K. Th1, Th2, and Th3 cytokine alterations in major depression. Journal of Affective Disorders 2005, 88:167-173.
29. Myint A.M., Kim Y.K., Verkerk R., Scharpé S., Steinbusch H., Leonard B. Kynurenine pathway in major depression: evidence of impaired neuroprotection. Journal of Affective Disorders 2007, 98(1-2):143-151.
30. Okuda S., Nishiyama N., Saito H., Katsuki H. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. Journal of Neurochemistry 1998, 70:299-307.
31. Perkins M.N., Stone T.W. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Research 1982, 247(1):184-187.
32. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., Maller J., Sklar P., de Bakker P.I., Daly M.J., Sham P.C. PLINK: a tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics 2007, 81(3):559-575.
33. Schwarcz R., Whetsell W.O., Mangano R.M. Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 1983, 219:316-318.
34. Stone T.W., Darlington L.G. Endogenous kynurenines as targets for drug discovery and development. Nature Reviews. Drug Discovery 2002, 1:609-620.
35. Sullivan P.F., de Geus E.J., Willemsen G., James M.R., Smit J.H., Zandbelt T., Arolt V., Baune B.T., Blackwood D., Cichon S., Coventry W.L., Domschke K., Farmer A., Fava M., Gordon S.D., He Q., Heath A.C., Heutink P., Holsboer F., Hoogendijk W.J., Hottenga J.J., Hu Y., Kohli M., Lin D., Lucae S., Macintyre D.J., Maier W., McGhee K.A., McGuffin P., Montgomery G.W., Muir W.J., Nolen W.A., Nothen M.M., Perlis R.H., Pirlo K., Posthuma D., Rietschel M., Rizzu P., Schosser A., Smit A.B., Smoller J.W., Tzeng J.Y., van D.R., Verhage M., Zitman F.G., Martin N.G., Wray N.R., Boomsma D.I., Penninx B.W. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Molecular Psychiatry 2009, 14(4):359-375.
36. van den Bogaert A.J., Sleegers K., De Z.S., Heyrman L., Norrback K.F., Adolfsson R., Van B.C., Del-Favero J. Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population. Archives of General Psychiatry 2006, 63(10):1103-1110.
37. van West D., Del-Favero J., Aulchenko Y., Oswald P., Souery D., Forsgren T., Sluijs S., Bel-Kacem S., Adolfsson R., Mendlewicz J., Van D.C., Deboutte D., Van B.C., Claes S. A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression. Molecular Psychiatry 2004, 9(3):287-292.
38. van West D., Van Den Eede F., Del-Favero J., Souery D., Norrback K.F., Van D.C., Sluijs S., Adolfsson R., Mendlewicz J., Deboutte D., Van Broeckhoven C., Claes S. Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression. Neuropsychopharmacology 2006, 31(3):620-627.
39. Verhagen M., van der M.A., van Deurzen P.A., Janzing J.G., rias-Vasquez A., Buitelaar J.K., Franke B. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Molecular Psychiatry 2010, 15(3):260-271.
40. Wittchen H.U., Wunderlich U., Gruschwitz S., Zaudig M. SKID-I, Strukturiertes Klinisches Interview für DSM-IV 1997, Hogrefe, Göttingen.
41. Yasui H., Takai K., Yoshida R., Hayaishi O. Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients. Proceedings of the National Academy of Sciences of the United States of America 1986, 83:6622-6626.
42. Yu P., Li Z., Zhang L., Tagle D.A., Cai T. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Gene 2006, 365:111-118.
43. Zhang X., Gainetdinov R.R., Beaulieu J.M., Sotnikova T.D., Burch L.H., Williams R.B., Schwartz D.A., Krishnan K.R., Caron M.G. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 2005, 45(1):11-16.
44. Zhang X., Gainetdinov R.R., Beaulieu J.M., Sotnikova T.D., Burch L.H., Williams R.B., Schwartz D.A., Krishnan K.R., Caron M.G. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 2005, 45(1):11-16.
45. Zill P., Baghai T.C., Zwanzger P., Schule C., Eser D., Rupprecht R., Moller H.J., Bondy B., Ackenheil M. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Molecular Psychiatry 2004, 9(11):1030-1036.