Xylitol inhibits inflammatory cytokine expression induced by lipopolysaccharide from Porphyromonas gingivalis

Clinical and Diagnostic Laboratory Immunology

Volumn 12, Issue 11, 2005, Pages 1285-1291

  Han, Su Ji ^a   Jeong, So Yeon ^a   Nam, Yun Ju ^a   Yang, Kyu Ho ^b   Lim, Hoi Soon ^c   Chung, Jin ^a  

^a Pusan National University   (South Korea)

^b Chonnam National University   (South Korea)

^c Chonnam National University Hwasun Hospital and Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR ALPHA; XYLITOL;

ANIMAL CELL; ARTICLE; BACTERIOSTASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENTAL CARIES; DOSE RESPONSE; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SUPERNATANT;

CARIOSTATIC AGENTS; CELL LINE; HUMANS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; PORPHYROMONAS GINGIVALIS; SWEETENING AGENTS; TUMOR NECROSIS FACTOR-ALPHA; XYLITOL;

EID: 27744477889     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.12.11.1285-1291.2005     Document Type: Article

References (49)

1. Agarwal, S., C. Baran, N. P. Piesco, J. C. Quintero, H. H. Langkamp, L. P. Johns, and C. S. Chandra. 1995. Synthesis of proinflammatory cytokines by human gingival fibroblasts in response to lipopolysaccharides and interleukin-1β. J. Periodontal Res. 30:382-389.
2. Agarwal, S., N. P., Piesco, L. P. Johns, and A. E. Riccelli. 1995. Differential expression of IL-1β, TNF-α, IL-6 and IL-8 in human monocytes in response to lipopolysaccharides from different microbes. J. Dent. Res. 74:1057-1065.
3. Baeuerle, P. A. 1991. The inducible transcription activator NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63-80.
4. Birkedal-Hansen, H. 1993. Role of cytokines and inflammatory mediators in tissue destruction. J. Periodontal Res. 28:500-510.
5. Birkedal-Hansen, H. 1993. Role of matrix metalloproteinases in human periodontal diseases. J. Periodontol. 64:474-484.
6. Blank, V., P. Kourilsky, and A. Israel. 1992. NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem. Sci. 17:135-140.
7. Bradshaw, D. J., and P. D. Marsh. 1994. Effect of sugar alcohols on the composition and metabolism of a mixed culture of oral bacteria in a chemostat. Caries Res. 28:251-256.
8. Canalis, E. 1986. Interleukin-1 had independent effects on deoxyribonucleic acid and collagen 2 synthesis in cultures of rat calvariae. Endocrinology 118:74-81.
9. Chen, L. L., and J. Yan. 2001. Porphyromonas gingivalis lipopolysaccharide activated bone resorption of osteoclasts by inducing IL-1, TNF, and PGE. Acta Pharmacol. Sin. 22:614-618.
10. Chiang, C-Y, G. Kyritsis, D. T. Graves, and S. Amar. 1999. Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect. Immun. 67:4231-4236.
11. Collart, M. A., P. Baeuerle, and P. Vassalli. 1990. Regulation of tumor necrosis factor-α transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol. Cell. Biol. 10:1498-1506.
12. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
13. Drouet, C., A. N. Shakhov, and C. V. Jongeneel. 1991. Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-α promoter in primary macrophages. J. Immunol. 147:1694-1700.
14. Dzink, J. L., S. S. Socransky, and A. D. Haffajee. 1988. The predominant cultivable microbiota of active and inactive lesions of destructive periodontal disease. J. Clin. Periodontol. 15:316-323.
15. Gemmell, E., R. I. Marshall, and G. J. Seymour. 1997. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol. 2000;14:112-143.
16. Gowen, M., D. D. Wood, and R. G. Russel. 1985. Stimulation of the proliferation of human bone cells in vitro by human monocyte products with interleukin-1 activity. J. Clin. Investig. 75:1223-1229.
17. Ingman, T., T. Sorsa, O. Lindy, H. Koski, and Y. T. Konttinen. 1994. Multiple forms of gelatinase/type IV collagenase in saliva and gingival crevicular fluid of periodontitis patients. J. Clin. Periodontol. 21:26-31.
18. Ishihara, Y., T. Nishihara, E. Maki, T. Noguchi, and T. Koga. 1991. Role of interleukin-1 and prostaglandin in in vitro bone resorption induced by Actinobacillus actinomycetemcomitans lipopolysaccharide. J. Periodontal Res. 26:155-160.
19. Kumada, H., Y. Haishima, T. Umemoto, and K. Tanamoto. 1995. Structural study on the free lipid A isolated from lipopolysaccharide of Porphyromonas gingivalis. J. Bacteriol. 177:2098-2106.
20. Lamont, R. J., and H. F. Jenkinson. 1998. Life below the gum line. Pathogenic mechanisms of Porphyromonas gingivalis. Microbiol. Mol. Biol. Rev. 62:1244-1263.
21. Loesche, W. J. 1984. The effect of sugar alcohols on plaque and saliva level of Streptococcus mutans. Swed. Dent. J. 8:125-135.
22. Makela, M., T. Salo, V. J. Uitto, and H. Larjava. 1994. Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status. J. Dent. Res. 73:1397-1406.
23. Makinen, K. K. 1976. Long-term tolerance of healthy human subjects to high amounts of xylitol and fructose: general and biochemical findings. Int. Z Vitam. Ernahrungsforsch. Beih. 15:92-104.
24. Makinen, K. K. 2000. The rocky road of xylitol to its clinical application. J. Dent. Res. 79:1352-1355.
25. Makinen, K. K., C. A. Bennett, P. P. Hujoel, P. J. Isokangas, K. P. Isotupa, H. R. Pape, Jr., and P. L. Makinen. 1995. Xylitol chewing gums and caries rates: a 40-month cohort study. J. Dent. Res. 74:1904-1913.
26. Makinen, K. K., and E. Soderling. 1980. A quantitative study of mannitol, sorbitol, xylitol, and xylose in wild berries and commercial fruits. J. Food Sci. 45:367-371.
27. Masada, M. P., R. Persson, J. S. Kenney, S. W. Lee, R. C. Page, and R. C. Allison. 1990. Measurement of interleukin-1α and -1β in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. J. Periodontal Res. 25:156-163.
28. Medzhitov, R., P. Preston-Hurlburt, E. Kopp, A. Stadlen, C. Chen, S. Ghosh, and C. A. Janeway, Jr. 1998. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2:253-258.
29. Nair, B. C., W. R. Mayberry, R. Dziak, P. B. Chen, M. Levine, and E. Hausmann. 1983. Biological effects of a purified lipopolysaccharide from Bacteroides gingivalis. J. Periodontal Res. 18:40-49.
30. Nishida, E., Y. Hara, T. Kaneko, Y. Ikeda, T. Ukai, and I. Kato. 2001. Bone resorption and local interleukin-1α and interleukin-1β synthesis induced by Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis lipopolysaccharide. J. Periodontal Res. 36:1-8.
31. Ohmori, Y., S. Hanazawa, S. Amano, T. Miyoshi, K. Hirose, and S. Kitano. 1987. Spontaneous production of thymocyte-activating factor by human gingival fibroblasts and its autoregulatory effects on their proliferation. Infect. Immun. 55:947-954.
32. Peldyak, J., and K. K. Makinen. 2002. Xylitol for caries prevention. J. Dent. Hyg. 76:276-285.
33. Quandt, K., K. Frech, H. Karas, E. Wingender, and T. Werner. 1995. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23:4878-4884.
34. Roberts, F. A., R. D. Hockett, R. P. Bucy, and S. M. Michalek. 1997. Quantitative assessment of inflammatory cytokine gene expression in chronic adult periodontitis. Oral Microbiol. Immunol. 12:336-344.
35. Rogers, A. H., K. A. Pilowsky, P. S. Zilm, and N. J. Gully. 1991. Effects of pulsing with xylitol on mixed continuous cultures of oral streptococci. Aust. Dent. J. 36:231-235.
36. Shakhov, A. N., M. A. Collart, P. Vassalli, S. A. Nedospasov, and C. V. Jongeneel. 1990. B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor-α gene in primary macrophages. J. Exp. Med. 171:35-47.
37. Slots, J., L. Bragd, M. Wikstrom, and G. Dahlen. 1986. The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis, and Bacteroides intermedius in destructive periodontal disease in adults. J. Clin. Periodontol. 13:570-577.
38. Soderling, E., K. K. Makinen, C. Y. Chen, H. R. Pape, Jr., W. Loesche, and P. L. Makinen. 1989. Effect of sorbitol, xylitol, and xylitol/sorbitol chewing gums on dental plaque. Caries Res. 23:378-384.
39. Söderling, E., L. Trahan, T. Tammiala-Salonen, and L. Häkkinen. 1997. Effects of xylitol, xylitol-sorbitol, and placebo chewing gums on the plaque of habitual xylitol consumers. Eur. J. Oral Sci. 105:170-177.
40. Tanzer, J. M. 1995. Xylitol chewing gum and dental caries. Int. Dent. J. 45:65-76.
41. Teng, Y. T., J. Sodek, and C. A. McCulloch. 1992. Gingival crevicular fluid gelatinase and its relationship to periodontal disease in human subjects. J. Periodontal Res. 27:544-552.
42. Tobias, P. S., J. Gegner, R. Tapping, R. S. Or, J. Methison, J. D. Lee, V. Kravchenko, J. Han, and R. J. Ulevitch. 1997. Lipopolysaccharide dependent cellular activation. J. Periodontal Res. 32:99-103.
43. Trahan, L. 1995. Xylitol: a review of its action on mutans streptococci and dental plaque: its clinical significance. Int. Dent. J. 45:77-92.
44. Unemori, E. N., N. Ehsani, M. Wang, S. Lee, J. McGuire, and E. P. Amento. 1994. Interleukin-1 and transforming growth factor-alpha: synergistic stimulation of metalloproteinases, PGE2, and proliferation in human fibroblasts. Exp. Cell Res. 210:166-171.
45. Vadeboncoeur, C., L. Trahan, C. Mouton, and D. Mayrand. 1983. Effect of xylitol on the growth and glycolysis of acidogenic oral bacteria. J. Dent. Res. 62:882-884.
46. Wennerholm, K., J. Arenas, D. Birkhed, J. Ruben, C. G. Emilson, and A. G. Dijkman. 1994. Effect of xylitol and sorbitol in chewing-gums on mutans streptococci, plaque pH and mineral loss of enamel. Caries Res. 28:48-54.
47. Westphal, O., and K. Jann. 1965. Bacterial lipopolysaccharides: extraction with phenol water and further applications of the procedure. Methods Carbohydr. Chem. 5:83-91.
48. Yamamoto, M., K. Fujihashi, T. Hiroi, J. R. McGhee, T. E. Van Dyke, and H. Kiyono. 1997. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J. Periodontal Res. 32:115-119.
49. Ziegler-Heitbrock, H. W., T. Sternsdorf, J. Liese, B. Belohradsky, C. Weber, A. Wedel, R. Schreck, P. Bauerle, and M. Strobel. 1993. Pyrrolidine dithiocarbamate inhibits NF-κB mobilization and TNF production in human monocytes. J. Immunol. 151:6986-6993.