Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

Journal of Lipid Research

Volumn 52, Issue 8, 2011, Pages 1494-1499

  Landry, France ^a   Chan, Chi Chung ^a   Huang, Zheng ^a   Leclair, Gregoire ^a   Li, Chun Sing ^a   Oballa, Renata ^a   Zhang, Lei ^a   Bateman, Kevin ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Deuterium labeled stearic acid; Liver SCD inhibitors; Plasma based assay

Indexed keywords

ACYL COENZYME A DESATURASE 1; DEUTERIUM; ENZYME INHIBITOR; MK 8245; OLEIC ACID; STEARIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FATTY ACID ANALYSIS; ISOTOPE LABELING; ISOTOPE TRACING; LIVER; MALE; NONHUMAN; PLASMA BASED ASSAY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS MONITORING; RAT; TARGET ORGAN;

EID: 79960693454     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M013177     Document Type: Article

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