Preparation of deuterium-labeled monounsaturated and saturated fatty acids for use as stable isotope metabolic tracers

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 49, Issue 14, 2006, Pages 1273-1285

  Crane, Sheldon N ^a   Bateman, Kevin ^a   Gagne, Sebastien ^a   Levesque, Jean Francois ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Deuterium label; Fatty acid; Metabolic syndrome; Stable isotope

Indexed keywords

METABOLISM; SATURATED FATTY ACIDS; UNSATURATED FATTY ACIDS;

DEUTERIUM LABEL; METABOLIC SYNDROMES; REACTION SEQUENCES; STABLE ISOTOPES; SYNTHETIC ROUTES;

DEUTERIUM;

DEUTERIUM; ISOTOPE; SATURATED FATTY ACID; STEARIC ACID; TRACER;

ARTICLE; CHEMICAL STRUCTURE; METABOLIC SYNDROME X; SYNTHESIS;

EID: 33947183997     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1142     Document Type: Article

References (18)

1. (a) Hutley L, Prins JB. Am J Med Sci 2005; 330(6): 280-290 and references therein;
2. (b) Kolovou GD, Anagnostopoulou KK, Cokkinos DV. Postgrad Med J 2005; 81: 358-366;
3. (c) Ayyobi AF, Brunzell JD. Am J Cardiol 2003; 92(4A): 27J-33J;
4. (d) Matsuzawa Y. Nature Clin Pract Cardiovasc Med 2006; 3: 35-43;
5. (e) Chan DC, Barrett HR, Watts GF. Clin Sci 2004; 107: 221-232.
6. (a) Cooper TG. The Tools of Biochemistry, Chapter 3. Wiley Interscience: New York 1977;
7. (b) Coggan AR. Proc Nutr Soc 1999; 58: 953-961.
8. Gagne S, Crane SN, Huang Z, Li C-S, Bateman KP, Levesque JF. J Lipid Res 2006 October 4 [Epub ahead of print].
9. (a) Navarro I, Font I, Fabrias G, Camps F. J Am Chem Soc 1997; 119: 11335-11336;
10. (b) Augustine RL, Peppen JF. J Chem Soc Chem Commun 1970; 571-572;
11. (c) Evans DA, Fu GC, Anderson BA. J Am Chem Soc 1992; 114: 6679-6685.
12. Macaulay SR. J Org Chem 1980; 45: 734-735.
13. (a) Stille JK, Simpson JH. J Am Chem Soc 1987; 109: 2138-2152;
14. (b) Poleschner H, Heydenreich M, Martin D. Synthesis 1991; 1231-1235;
15. (c) Schwarz M, Waters RM. Synthesis 1972; 567-568.
16. (a) Magoon EF, Slaugh LH. Tetrahedron 1967; 23: 4509-4515;
17. (b) Ohloff G, Vial C, Näf F, Pawlak M. Helv Chim Acta 1977; 60: 1161-1174.
18. Osborn JA, Jardine FH, Young JF, Wilkinson G. J Chem Soc A 1966; 1711-1732.