A three-stage-integrative approach for the identification of potential hepatotoxic compounds from botanical products

International Journal of Toxicology

Volumn 30, Issue 3, 2011, Pages 287-299

  Jin, Yecheng ^a   Zhao, Xiaoping ^b   Zhang, Yufeng ^a   Li, Xiang ^a   Nie, Xiaojing ^a   Wang, Yi ^a   Fan, Xiaohui ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

dietary supplement; fluorescein diacetate; fluorescence; hepatotoxity; herbal medicine

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMIODARONE; ARISTOLOCHIA EXTRACT; ARISTOLOCHIC ACID; ARISTOLOCHIC ACID IVA; ARISTOLODIONE; CHLORPROMAZINE; DIPHENHYDRAMINE; FLUORESCEIN DIACETATE; KETOTIFEN; NATURAL PRODUCT; PARACETAMOL; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PROPRANOLOL; ROSIGLITAZONE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ARISTOLOCHIA; ARTICLE; CELL VIABILITY; CHEMICAL LABELING; CONTROLLED STUDY; EXTRACTION; FLUORESCEIN DIACETATE BASED AUTOMATIC MICROSCOPY SCREENING; FRUIT; HUMAN; HUMAN CELL; IMAGE ANALYSIS; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MASS SPECTROMETRY; MICROSCOPY; PROCESS OPTIMIZATION; SCREENING; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; THREE STAGE INTEGRATIVE APPROACH; TOXICITY TESTING; TOXIN ANALYSIS; VALIDITY;

CELL LINE; CHROMATOGRAPHY, LIQUID; DIETARY SUPPLEMENTS; FLUORESCEINS; HERBAL MEDICINE; HUMANS; LIMIT OF DETECTION; LIVER; MASS SPECTROMETRY; PLANT EXTRACTS;

IVA;

EID: 79960691114     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581811401046     Document Type: Article

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