HIWI expression profile in cancer cells and its prognostic value for patients with colorectal cancer

Chinese Medical Journal

Volumn 124, Issue 14, 2011, Pages 2144-2149

  Zeng, Yan ^a   Qu, Li Ke ^a   Meng, Lin ^a   Liu, Cai Yun ^a   Dong, Bin ^a   Xing, Xiao Fang ^a   Wu, Jian ^a   Shou, Cheng chao ^a  

^a PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Colorectal neoplasms; HIWI; Prognosis

Indexed keywords

HIWI PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE FREE SURVIVAL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OVERALL SURVIVAL; PROGNOSIS; PROTEIN EXPRESSION;

ARGONAUTE PROTEINS; BLOTTING, WESTERN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; PROGNOSIS;

EID: 79960669475     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.14.012     Document Type: Article

References (20)

1. Lin H, Spradling AC. A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development 1997; 124: 2463-2476.
2. Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H. A novel class of evolutionarily conserved genes defined by Piwi are essential for stem cell self renewal. Genes Dev 1998; 12: 3715-3727.
3. Sharma AK, Nelson MC, Brandt JE, Wessman M, Mahmud N, Weller KP, et al. Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. Blood 2001; 97: 426-434.
4. Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin H. Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene 2002; 21: 3988-3999.
5. Taubert H, Greither T, Kaushal D, Würl P, Bache M, Bartel F, et al. Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. Oncogene 2007; 26: 1098-1100.
6. Taubert H, Würl P, Greither T, Kappler M, Bache M, Bartel F, et al. Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients. Oncogene 2007; 26: 7170-7174.
7. Grochola LF, Greither T, Taubert H, Möller P, Knippschild U, Udelnow A, et al. The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumor-related death. Br J Cancer 2008; 99: 1083-1088.
8. Liu X, Sun Y, Guo J, Ma H, Li J, Dong B, et al. Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer 2006; 118: 1922-1929.
9. He W, Wang Z, Wang Q, Fan Q, Shou C, Wang J, et al. Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis. BMC Cancer 2009; 9: 426.
10. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111.
11. Deng CH, Zhang QP. Leukemia stem cells in drug resistance and metastasis. Chin Med J 2010; 123: 954-960.
12. Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003; 3: 895-902.
13. Si ZC, Liu J. What "helps" tumors evade vascular targeting treatment? Chin Med J 2008; 121: 844-849.
14. Li S, Meng L, Zhu C, Wu L, Bai X, Wei J, et al. The universal overexpression of a cancer testis antigen hiwi is associated with cancer angiogenesis. Oncol Rep 2010; 23: 1063-1068.
15. Yang LJ, Chen Y, Ma Q, Fang J, He J, Cheng YQ, et al. Effect of betulinic acid on the regulation of Hiwi and cyclin B1 in human gastric adenocarcinoma AGS cells. Acta Pharmacol Sin 2010; 31: 66-72.
16. King FJ, Szakmary A, Cox DN, Lin H. Yb modulates the divisions of both germline and somatic stem cells through piwi-and hh-mediated mechanisms in the Drosophila ovary. Mol Cell 2001; 7: 497-508.
17. Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev 2010; 24: 2001-2012.
18. Morris JP 4th, Wang SC, Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer 2010; 10: 683-695.
19. Lee JH, Schütte D, Wulf G, Füzesi L, Radzun HJ, Schweyer S, et al. Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. Hum Mol Genet 2006; 15: 201-211.
20. Ye Y, Yin DT, Chen L, Zhou Q, Shen R, He G, et al. Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis. PLoS One 2010; 5: e13406.