Curcumin is a lipid dependent inhibitor of the Na,K-ATPase that likely interacts at the protein-lipid interface

Biochimica et Biophysica Acta - Biomembranes

Volumn 1808, Issue 1, 2011, Pages 466-473

  Mahmmoud, Yasser A ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Curcumin; Diferuloylmethane; Lipid raft; Membrane composition; Na,K ATPase; P type ATPases

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CHOLESTEROL; CURCUMIN; POLYPHENOL; SPHINGOMYELIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG ACTIVITY; DRUG POTENCY; DRUG PROTEIN BINDING; KIDNEY; MEMBRANE BINDING; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; SWINE; TEMPERATURE SENSITIVITY;

ANIMALS; CROSS-LINKING REAGENTS; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAVONOIDS; KIDNEY; LIPIDS; MEMBRANE MICRODOMAINS; PHENOLS; PROTEIN BINDING; PROTEINS; SODIUM-POTASSIUM-EXCHANGING ATPASE; SWINE; TEMPERATURE;

SUIDAE;

EID: 78649790906     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2010.09.021     Document Type: Article

References (47)

1. H.P.T. Ammon, and M.A. Wahl Pharmacology of Curcuma longa Planta Med. 57 1991 1 7
2. J. Epstein, I.R. Sanderson, and T.T. MacDonald Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies Br. J. Nutr. 103 2010 1545 1557
3. S.C. Gupta, J.H. Kim, S. Prasad, and B.B. Aggarwal Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals Cancer Metastasis Rev. 29 2010 405 434
4. M. Nagabhushan, and S.V. Bhide Curcumin as an inhibitor of cancer J. Am. Coll. Nutr. 11 1992 192 198
5. M.E. Egan, M. Pearson, S.A. Weiner, V. Rajendran, D. Rubin, J. Glockner-Pagel, S. Canny, K. Du, G.L. Lukacs, and M.J. Caplan Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects Science 304 2004 600 602
6. F. Yang, G.P. Lim, A.N. Begum, O.J. Ubeda, M.R. Simmons, S.S. Ambegaokar, P.P. Chen, C.G. Glabe, S.A. Frautschy, and G.M. Cole Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo J. Biol. Chem. 280 2005 5892 5901
7. R.C. Reddy, P.G. Vatsala, V.G. Keshamouni, G. Padmanaban, and P.N. Rangarajan Curcumin for malaria therapy Biochem. Biophys. Res. Commun. 326 2005 472 474
8. M. Hasmeda, and G.M. Polya Inhibition of cyclic AMP-dependent protein kinase by curcumin Phytochemistry 42 1996 599 605
9. J.Y. Liu, S.J. Lin, and J.K. Lin Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells Carcinogenesis 14 1993 857 861
10. Y.A. Mahmmoud Modulation of protein kinase C by curcumin; inhibition and activation switched by calcium ions Br. J. Pharmacol. 150 2007 200 208
11. J. Zheng, and V.D. Ramirez Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals Br. J. Pharmacol. 130 2000 1115 1123
12. S. Singh, and B.B. Aggarwal Activation of transcription factor NF-B is suppressed by curcumin (Diferuloylmethane) J. Biol. Chem. 270 1995 24995 25000
13. 2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP Eur. J. Biochem. 268 2001 6318 6327
14. 2+ J. Biol. Chem. 276 2001 46905 46911
15. 2+ pump and its control by anions and curcumin in skeletal and cardiac sarcoplasmic reticulum J. Biol. Chem. 277 2002 13900 13906
16. + occlusion, and inhibition of hydrolytic activity Br. J. Pharmacol. 145 2005 236 245
17. Y. Song, N.D. Sonawane, D. Salinas, L. Qian, N. Pedemonte, L.J. Galietta, and A.S. Verkman Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models J. Biol. Chem. 279 2004 40629 40633
18. A. Dragomir, J. Bjorstad, L. Hjelte, and G.M. Roomans Curcumin does not stimulate cAMP-mediated chloride transport in cystic fibrosis airway epithelial cells Biochem. Biophys. Res. Commun. 322 2004 447 451
19. T.W. Loo, M.C. Bartlett, and D.M. Clarke Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein Biochem. Biophys. Res. Commun. 325 2004 580 585
20. - channel activity J. Biol. Chem. 280 2005 5221 5226
21. M. Edidin Lipids on the frontier: a century of cell-membrane bilayers Nat. Rev. Mol. Cell Biol. 4 2003 414 418
22. D. Lingwood, and K. Simons Lipid rafts as a membrane-organizing principle Science 327 2010 46 50
23. F.D. Oakley, R.L. Smith, and J.F. Engenhardt Lipid rafts and caveolin-1 coordinate interleukin-1β (IL-1β)-dependent activation of NFκB by controlling endocytosis of Nox2 and IL-1β receptor 1 from the plasma membrane J. Biol. Chem. 284 2009 33255 33264
24. I. Klodos, M. Esmann, and R.L. Post Large-scale preparation of sodium-potassium ATPase from kidney outer medulla Kidney Int. 62 2002 2097 2100
25. S.J. Karlish, and U. Pick Sidedness of the effects of sodium and potassium ions on the conformational state of the sodium-potassium pump J. Physiol. 312 1981 505 529
26. H.S. Penefsky A centrifuged-columen procedure for the measurement of ligand binding by beef heart F1 Meth. Enzymol. 56 1979 527 530
27. +-ATPase into liposomes: determination of sidedness and orientation Meth. Enzymol. 156 1988 156 167
28. R. Schroeder, E. London, and D. Brown Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior Proc. Natl. Acad. Sci. USA 91 1994 12130 12134
29. S.J. Karlish, R. Goldshleger, and W.D. Stein A 19-kDa C-terminal tryptic fragment of the alpha chain of Na/K-ATPase is essential for occlusion and transport of cations Proc. Natl. Acad. Sci. USA 87 1990 4566 4570
30. Y.A. Mahmmoud, and F. Cornelius Protein kinase C phosphorylation of purified Na, K-ATPase: C-terminal phosphorylation sites at the alpha- and gamma-subunits close to the inner face of the plasma membrane Biophys. J. 82 2002 1907 1919
31. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
32. Y.A. Mahmmoud, H. Vorum, and F. Cornelius Identification of a phospholemman-like protein from shark rectal glands. Evidence for indirect regulation of Na, K-ATPase by protein kinase c via a novel member of the FXYDY family J. Biol. Chem. 275 2000 35969 35977
33. Y.A. Mahmmoud, G. Cramb, A.B. Maunsbach, C.P. Cutler, L. Meischke, and F. Cornelius Regulation of Na, K-ATPase by PLMS, the phospholemman-like protein from shark: molecular cloning, sequence, expression, cellular distribution, and functional effects of PLMS J. Biol. Chem. 278 2003 37427 37438
34. K.S. Song, S. Li, T. Okamoto, L.A. Quilliam, M. Sargiacomo, and M.P. Lisanti Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains J. Biol. Chem. 271 1996 9690 9697
35. A.G. Lee How lipids affect the activities of integral membrane proteins Biochim. Biophys. Acta 1666 2004 62 87
36. A. Gebri, and J.M. Maixent Fatty acid-induced modulation of ouabain responsiveness of rat Na, K-ATPase isoforms J. Membr. Biol. 168 1999 19 27
37. H. Ogawa, T. Shinoda, F. Cornelius, and C. Toyoshima Crystal structure of the sodium potassium pump (Na+, K+-ATPase) with bound potassium and ouabain Proc. Natl. Acad. Sci. USA 106 2009 13742 13747
38. M. Esmann Oligomycin interaction with Na, K-ATPase: oligomycin binding and dissociation are slow processes Biochim. Biophys. Acta 1064 1991 31 36
39. T. Yeung, G.E. Gilbert, J. Shi, J. Silvius, A. Kapus, and S. Grinstein Membrane phosphatidylserine regulates surface charge and protein localization Science 319 2008 210 213
40. F. Cornelius Test Modulation of FXYD interaction with Na,K-ATPase by anionic phospholipids and protein kinase phosphorylation Biochemistry 46 2007 2371 2379
41. W.C. Hung, F.Y. Chen, C.C. Lee, Y. Sun, M.T. Lee, and H.W. Huang Membrane-thinning effect of curcumin Biophys. J. 94 2008 4331 4338
42. H.I. Ingolfsson, R.E. Koeppe, and O.S. Andersen Curcumin is a modulator of bilayer material properties Biochemistry 46 2007 10384 10391
43. D.A. Brown, and E. London Structure and function of sphingolipid- and cholesterol-rich membrane rafts J. Biol. Chem. 275 2000 17221 17224
44. F. Cornelius, N. Turner, and H.R. Christensen Modulation of Na, K-ATPase by phospholipids and cholesterol. II. Steady-state and presteady-state kinetics Biochemistry 42 2003 8541 8549
45. A. Shainskaya, and S.J. Karlish Evidence that the cation occlusion domain of Na/K-ATPase consists of a complex of membrane-spanning segments. Analysis of limit membrane-embedded tryptic fragments J. Biol. Chem. 269 1994 10780 10789
46. Y.A. Mahmmoud, H. Vorum, and F. Cornelius Interaction of FXYD10 (PLMS) with Na, K-ATPase from shark rectal glands. Close proximity of Cys74 of FXYD10 to Cys254 in the A domain of the alpha-subunit revealed by intermolecular thiol cross-linking J. Biol. Chem. 280 2005 27776 27782
47. K. Bernard, W. Wang, R. Narlawar, B. Schmidt, and K.L. Kirk Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms J. Biol. Chem. 284 2009 30754 30765