Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne

British Journal of Dermatology

Volumn 165, Issue 2, 2011, Pages 302-310

  Lumsden, K R ^a   Nelson, A M ^a,b   Dispenza, M C ^a   Gilliland, K L ^a,b   Cong, Z ^a,b   Zaenglein, A L ^b   Thiboutot, D M ^a,b  

^a PENN STATE CANCER INSTITUTE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 8; ISOTRETINOIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; RETINOIC ACID; TOLL LIKE RECEPTOR 2;

ACNE; ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; PROTEIN EXPRESSION; PROTEIN SECRETION; SEBACEOUS CELL; SKIN CELL; SKIN SURFACE; TISSUE LEVEL;

ACNE VULGARIS; ACUTE-PHASE PROTEINS; ADOLESCENT; ADULT; CELLS, CULTURED; COHORT STUDIES; DERMATOLOGIC AGENTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-8; ISOTRETINOIN; LIPOCALINS; PROPIONIBACTERIUM ACNES; PROTO-ONCOGENE PROTEINS; SEBACEOUS GLANDS; SKIN; YOUNG ADULT;

EID: 79960643879     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10362.x     Document Type: Article

References (39)

1. Peck GL,. Prolonged remissions of cystic acne with 13-cis-retinoic acid. N Engl J Med 1979; 300: 329-33. (Pubitemid 9114884)
2. Peck GL, Yoder FW,. Treatment of lamellar ichthyosis and other keratinising dermatoses with an oral synthetic retinoid. Lancet 1976; 2: 1172-4.
3. Lammer EJ, Chen DT, Hoar RM, et al. Retinoic acid embryopathy. N Engl J Med 1985; 313: 837-41. (Pubitemid 15250197)
4. Lammer EJ, Flannery DB, Barr M,. Does isotretinoin cause limb reduction defects? Lancet 1985; 2: 328. (Pubitemid 15045149)
5. Nelson AM, Gilliland KL, Cong Z, et al. 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes. J Invest Dermatol 2006; 126: 2178-89. (Pubitemid 44413163)
6. Nelson AM, Zhao W, Gilliland KL, et al. Isotretinoin temporally regulates distinct sets of genes in patient skin. J Invest Dermatol 2009; 129: 1038-42.
7. Nelson AM, Zhao W, Gilliland KL, et al. Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells. J Clin Invest 2008; 118: 1468-78. (Pubitemid 351500440)
8. Lindwall G, Hsieh EA, Misell LM, et al. Heavy water labeling of keratin as a non-invasive biomarker of skin turnover in vivo in rodents and humans. J Invest Dermatol 2006; 126: 841-8.
9. Leyden JJ, McGinley KJ,. Effect of 13-cis-retinoic acid on sebum production and Propionibacterium acnes in severe nodulocystic acne. Arch Dermatol Res 1982; 272: 331-7. (Pubitemid 12113034)
10. Trivedi NR, Gilliland KL, Zhao W, et al. Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. J Invest Dermatol 2006; 126: 1071-9.
11. Thiboutot D, Jabara S, McAllister J, et al. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol 2003; 120: 905-14. (Pubitemid 36702897)
12. Kjeldsen L, Bainton DF, Sengelov H, et al. Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 1994; 83: 799-807. (Pubitemid 24043742)
13. Cowland JB, Sorensen OE, Sehested M, et al. Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha. J Immunol 2003; 171: 6630-9. (Pubitemid 37532095)
14. Kim J, Ochoa MT, Krutzik SR, et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002; 169: 1535-41. (Pubitemid 34809200)
15. Nagy I, Pivarcsi A, Kis K, et al. Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect 2006; 8: 2195-205. (Pubitemid 44335873)
16. Phan J, Kanchanapoomi M, Liu P, et al. P. acnes induces inflammation via TLR2 and upregulates antimicrobial activity in sebocytes. J Invest Dermatol 2007; 127: S126.
17. Hughes BR, Cunliffe WJ,. A prospective study of the effect of isotretinoin on the follicular reservoir and sustainable sebum excretion rate in patients with acne. Arch Dermatol 1994; 130: 315-18. (Pubitemid 24107869)
18. Devireddy LR, Gazin C, Zhu X, et al. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 2005; 123: 1293-305. (Pubitemid 41821786)
19. Lin HH, Li WW, Lee YC, et al. Apoptosis induced by uterine 24p3 protein in endometrial carcinoma cell line. Toxicology 2007; 234: 203-15. (Pubitemid 46635956)
20. Devireddy LR, Hart DO, Goetz DH, et al. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell 2010; 141: 1006-17.
21. Bao G, Clifton M, Hoette TM, et al. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol 2010; 6: 602-9.
22. Goetz DH, Holmes MA, Borregaard N, et al. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 2002; 10: 1033-43. (Pubitemid 36001971)
23. Nakatsuji T, Kao MC, Zhang L, et al. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol 2010; 130: 985-94.
24. Lee DY, Yamasaki K, Rudsil J, et al. Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill Propionibacterium acnes. J Invest Dermatol 2008; 128: 1863-6. (Pubitemid 351847367)
25. Lee JH, Kye KC, Seo EY, et al. Expression of neutrophil gelatinase-associated lipocalin in calcium-induced keratinocyte differentiation. J Korean Med Sci 2008; 23: 302-6.
26. Eckert RL, Broome AM, Ruse M, et al. S100 proteins in the epidermis. J Invest Dermatol 2004; 123: 23-33. (Pubitemid 38833459)
27. Harder J, Schroder JM,. Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins. J Leukoc Biol 2005; 77: 476-86. (Pubitemid 40489523)
28. Frohm M, Agerberth B, Ahangari G, et al. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 1997; 272: 15258-63. (Pubitemid 27255544)
29. Boni R, Nehrhoff B,. Treatment of Gram-negative folliculitis in patients with acne. Am J Clin Dermatol 2003; 4: 273-6. (Pubitemid 36506431)
30. Amichai B, Grunwald MH, Halevy S, [ Treatment of Gram-negative folliculitis with isotretinoin ]. Harefuah 1993; 124: 200-1, 247.
31. James WD, Leyden JJ,. Treatment of Gram-negative folliculitis with isotretinoin: positive clinical and microbiologic response. J Am Acad Dermatol 1985; 12: 319-24. (Pubitemid 15171500)
32. Jones DH, Cunliffe WJ, King K,. Treatment of Gram-negative folliculitis with 13-cis-retinoic acid. Br J Dermatol 1982; 107: 252-3. (Pubitemid 12041550)
33. Neubert U, Plewig G, Ruhfus A,. Treatment of Gram-negative folliculitis with isotretinoin. Arch Dermatol Res 1986; 278: 307-13. (Pubitemid 16096027)
34. Plewig G, Nikolowski J, Wolff HH,. Action of isotretinoin in acne rosacea and Gram-negative folliculitis. J Am Acad Dermatol 1982; 6: 766-85.
35. Leyden JJ, McGinley KJ, Foglia AN,. Qualitative and quantitative changes in cutaneous bacteria associated with systemic isotretinoin therapy for acne conglobata. J Invest Dermatol 1986; 86: 390-3. (Pubitemid 16050015)
36. Caramuta S, De Cecco L, Reid JF, et al. Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR. Int J Cancer 2006; 119: 1599-606. (Pubitemid 44258765)
37. Jayaraman A, Roberts KA, Yoon J, et al. Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte-secreted protein response to IL-1beta: a proteomic analysis. Biotechnol Bioeng 2005; 91: 502-15. (Pubitemid 41099036)
38. Draper DW, Bethea HN, He YW,. Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci. Immunol Lett 2006; 102: 202-14. (Pubitemid 43053089)
39. Flo TH, Smith KD, Sato S, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004; 432: 917-21. (Pubitemid 40037155)