Nanoscale studies of protein-membrane interactions in blood clotting

Journal of Thrombosis and Haemostasis

Volumn 9, Issue 1 S, 2011, Pages 162-167

  Morrissey, J H ^a   Tajkhorshid, E ^a,b   Rienstra, C M ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Gla domains; Membranes; Phosphatidylserine; Phospholipids

Indexed keywords

4 CARBOXYGLUTAMIC ACID; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; CALCIUM ION; LIPOSOME; MAGNESIUM ION; NANODISC; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PHOSPHOSERINE; PROTHROMBIN; THROMBOPLASTIN;

BLOOD CLOTTING; EXPERIMENTAL MODEL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; MEMBRANE; MOLECULAR DYNAMICS; NANOANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN INTERACTION; REVIEW; SIGNAL NOISE RATIO; SIMULATION;

BLOOD COAGULATION; CELL MEMBRANE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NANOTECHNOLOGY; PROTEINS;

EID: 79960639587     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2011.04300.x     Document Type: Review

References (39)

1. Zwaal RFA, Comfurius P, Bevers EM. Lipid-protein interactions in blood coagulation. Biochim Biophys Acta 1998; 1376: 433-53.
2. 2+ sites in factor VIIa. J Biol Chem 2006; 281: 24873-88.
3. Falls LA, Furie BC, Jacobs M, Furie B, Rigby AC. The omega-loop region of the human prothrombin gamma-carboxyglutamic acid domain penetrates anionic phospholipid membranes. J Biol Chem 2001; 276: 23895-902.
4. Nelsestuen GL. Enhancement of vitamin-K-dependent protein function by modification of the gamma-carboxyglutamic acid domain: studies of protein C and factor VII. Trends Cardiovasc Med 1999; 9: 162-7.
5. Huang M, Rigby AC, Morelli X, Grant MA, Huang GQ, Furie B, Seaton B, Furie BC. Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol 2003; 10: 751-6.
6. 2+ in membrane binding of blood coagulation factors. Structure 2008; 16: 72-81.
7. Morrissey JH, Pureza V, Davis-Harrison RL, Sligar SG, Ohkubo YZ, Tajkhorshid E. Blood clotting reactions on nanoscale phospholipid bilayers. Thromb Res 2008; 122 (Suppl. 1): S23-6.
8. Srivastava A, Wang J, Majumder R, Rezaie AR, Stenflo J, Esmon CT, Lentz BR. Localization of phosphatidylserine binding sites to structural domains of factor Xa. J Biol Chem 2002; 277: 1855-63.
9. Lecompte MF. Interaction of an amphitropic protein (factor Xa) with membrane models in a complex system. Biochim Biophys Acta 2005; 1724: 307-14.
10. Husten EJ, Esmon CT, Johnson AE. The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J Biol Chem 1987; 262: 12953-61.
11. Autin L, Steen M, Dahlback B, Villoutreix BO. Proposed structural models of the prothrombinase (FXa-FVa) complex. Proteins 2006; 63: 440-50.
12. Shaw AW, McLean MA, Sligar SG. Phospholipid phase transitions in homogeneous nanometer scale bilayer discs. FEBS Lett 2004; 556: 260-4.
13. Denisov IG, Grinkova YV, Lazarides AA, Sligar SG. Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size. J Am Chem Soc 2004; 126: 3477-87.
14. Bayburt TH, Carlson JW, Sligar SG. Reconstitution and imaging of a membrane protein in a nanometer-size phospholipid bilayer. J Struct Biol 1998; 123: 37-44.
15. Bayburt TH, Sligar SG. Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks. Proc Natl Acad Sci U S A 2002; 99: 6725-30.
16. Bayburt TH, Sligar SG. Self-assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers. Protein Sci 2003; 12: 2476-81.
17. Sligar SG. Finding a single-molecule solution for membrane proteins. Biochem Biophys Res Commun 2003; 312: 115-9.
18. Baas BJ, Denisov IG, Sligar SG. Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment. Arch Biochem Biophys 2004; 430: 218-28.
19. Shih AY, Denisov IG, Phillips JC, Sligar SG, Schulten K. Molecular dynamics simulations of discoidal bilayers assembled from truncated human lipoproteins. Biophys J 2005; 88: 548-56.
20. Denisov IG, McLean MA, Shaw AW, Grinkova YV, Sligar SG. Thermotropic phase transition in soluble nanoscale lipid bilayers. J Phys Chem B 2005; 109: 15580-8.
21. Shaw AW, Pureza VS, Sligar SG, Morrissey JH. The local phospholipid environment modulates the activation of blood clotting. J Biol Chem 2007; 282: 6556-63.
22. Nelsestuen GL, Broderius M. Interaction of prothrombin and blood-clotting factor X with membranes of varying composition. Biochemistry 1977; 16: 4172-7.
23. Civjan NR, Bayburt TH, Schuler MA, Sligar SG. Direct solubilization of heterologously expressed membrane proteins by incorporation into nanoscale lipid bilayers. BioTechniques 2003; 35: 556-60.
24. Leitz AJ, Bayburt TH, Barnakov AN, Springer BA, Sligar SG. Functional reconstitution of Beta2-adrenergic receptors utilizing self-assembling Nanodisc technology. BioTechniques 2006; 40: 601-2. 4, 6, passim.
25. Krishnaswamy S, Field KA, Edgington TS, Morrissey JH, Mann KG. Role of the membrane surface in the activation of human coagulation factor X. J Biol Chem 1992; 267: 26110-20.
26. 2+, phospholipids and tissue-factor apoprotein to the activation of human blood-coagulation factor X by activated factor VII. Biochem J 1990; 265: 327-36.
27. Hathcock JJ, Rusinova E, Gentry RD, Andree H, Nemerson Y. Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions. Biochemistry 2005; 44: 8187-97.
28. Ohkubo YZ, Morrissey JH, Tajkhorshid E. Dynamical view of membrane binding and complex formation of human factor VIIa and tissue factor. J Thromb Haemost 2010; 8: 1044-53.
29. McCallum CD, Hapak RC, Neuenschwander PF, Morrissey JH, Johnson AE. The location of the active site of blood coagulation factor VIIa above the membrane surface and its reorientation upon association with tissue factor: a fluorescence energy transfer study. J Biol Chem 1996; 271: 28168-75.
30. McCallum CD, Su B, Neuenschwander PF, Morrissey JH, Johnson AE. Tissue factor positions and maintains the factor VIIa active site far above the membrane surface even in the absence of the factor VIIa Gla domain - A fluorescence resonance energy transfer study. J Biol Chem 1997; 272: 30160-6.
31. Morrissey JH, Neuenschwander PF, Huang Q, McCallum CD, Su B, Johnson AE. Factor VIIa tissue factor: functional importance of protein- membrane interactions. Thromb Haemost 1997; 78: 112-6.
32. Waters EK, Yegneswaran S, Morrissey JH. Raising the active site of factor VIIa above the membrane surface reduces its procoagulant activity but not factor VII autoactivation. J Biol Chem 2006; 281: 26062-8.
33. Franks WT, Wylie BJ, Schmidt HL, Nieuwkoop AJ, Mayrhofer RM, Shah GJ, Graesser DT, Rienstra CM. Dipole tensor-based atomic-resolution structure determination of a nanocrystalline protein by solid-state NMR. Proc Natl Acad Sci U S A 2008; 105: 4621-6.
34. Li Y, Kijac AZ, Sligar SG, Rienstra CM. Structural analysis of nanoscale self-assembled discoidal lipid bilayers by solid-state NMR spectroscopy. Biophys J 2006; 91: 3819-28.
35. Kijac AZ, Li Y, Sligar SG, Rienstra CM. Magic-angle spinning solid-state NMR spectroscopy of nanodisc-embedded human CYP3A4. Biochemistry 2007; 46: 13696-703.
36. Kijac A, Shih AY, Nieuwkoop AJ, Schulten K, Sligar SG, Rienstra CM. Lipid-protein correlations in nanoscale phospholipid bilayers determined by solid-state nuclear magnetic resonance. Biochemistry 2010; 49: 9190-8.
37. Boettcher JM, Davis-Harrison RL, Clay MC, Nieuwkoop AJ, Ohkubo YZ, Tajkhorshid E, Morrissey JH, Rienstra CM. Atomic view of calcium-induced clustering of phosphatidylserine in mixed lipid bilayers. Biochemistry 2011; 50: 2264-73.
38. 15N resonance assignments of the extracellular domain of tissue factor. Biomol NMR Assign 2010; 4: 183-5.
39. Banner DW, D'Arcy A, Chène C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 1996; 380: 41-6.