Management of keratoconus: Current scenario

British Journal of Ophthalmology

Volumn 95, Issue 8, 2011, Pages 1044-1050

  Jhanji, Vishal ^a,b   Sharma, Namrata ^c   Vajpayee, Rasik B ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

POLY(METHYL METHACRYLATE); RIBOFLAVIN;

ANISOMETROPIA; ASTIGMATISM; CONSERVATIVE TREATMENT; CONTACT LENS; CORNEA TRANSPLANTATION; CORNEAL COLLAGEN CROSS LINKING; CROSS LINKING; DEBRIDEMENT; DEEP ANTERIOR LAMELLAR KERATOPLASTY; DESCEMET MEMBRANE; DISEASE COURSE; EPIKERATOPHAKIA; FEMTOSECOND LASER; HUMAN; INTRACORNEAL RING SEGMENT; KERATOCONUS; KERATOPLASTY; LENS IMPLANT; MICROKERATOME ASSISTED LAMELLAR KERATOPLASTY; MYOPIA; PENETRATING KERATOPLASTY; PHAKIC INTRAOCULAR LENS; PHOTOREFRACTIVE KERATECTOMY; PRIORITY JOURNAL; REVIEW; TORIC INTRAOCULAR LENS; TUCK IN LAMELLAR KERATOPLASTY; ULTRAVIOLET A RADIATION; VISUAL ACUITY;

CONTACT LENSES; CORNEAL TRANSPLANTATION; CROSS-LINKING REAGENTS; HUMANS; KERATOCONUS;

EID: 79960630461     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjo.2010.185868     Document Type: Review

References (106)

1. Duke-Elder S, Leigh AG. Keratoconus. In: System of Ophthalmology, Vol. VIII. Part 2. Diseases of the Outer Eye, Cornea and Sclera. London: Henry Kimpton, 1965:964-74.
2. Krachmer JH, Feder RS, Belin MW. Keratoconus and related non-inflammatory corneal thinning disorders. Surv Ophthalmol 1984;28:293-322. (Pubitemid 14152658)
3. Lawless M, Coster DJ, Phillips AJ, et al. Keratoconus: diagnosis and management. Aust NZ J Ophthalmol 1989;17:33-60. (Pubitemid 19150918)
4. Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998;42:297-319.
5. Lass JH, Lembach RG, Park SB, et al. Clinical management of keratoconus. A multicenter analysis. Ophthalmology 1990;97:433-45.
6. Wagner H, Barr JT, Zadnik K. Collaborative Longitudinal Evaluation of Keratoconus (CLEK) study: methods and findings to date. Cont Lens Anterior Eye 2007;30:223-32. (Pubitemid 47289251)
7. Pramanik S, Musch DC, Sutphin JE, et al. Extended long-term outcomes of penetrating keratoplasty for keratoconus. Ophthalmology 2006;113:1633-8. (Pubitemid 44308558)
8. Smiddy WE, Hamburg TR, Kracher GP, et al. Keratoconus. Contact lens or keratoplasty? Ophthalmology 1988;95:487-92.
9. Garcia-Lledo M, Feinbaum C, Alio JL. Contact lens fitting in keratoconus. Compr Ophthalmol Update 2006;7:47-52. (Pubitemid 43797429)
10. Ozkurt YB, Sengor T, Kurna S, et al. Rose K contact lens fitting for keratoconus. Int Ophthalmol 2008;28:395-8.
11. Visser ES, Visser R, van Lier HJ, et al. Modern scleral lenses part II: patient satisfaction. Eye Contact Lens 2007;33:21-5. (Pubitemid 46114825)
12. Segal O, Barkana Y, Hourovitz D, et al. Scleral contact lenses may help where other modalities fail. Cornea 2003;22:308-10. (Pubitemid 36578527)
13. Wollensak G, Spörl E, Seiler T. Treatment of keratoconus by collagen cross linking. Ophthalmologe 2003;100:44-9. (Pubitemid 36717241)
14. Caporossi A, Baiocchi S, Mazzotta C, et al. Parasurgical therapy for keratoconus by riboflavin ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg 2006;32:837-45. (Pubitemid 43831548)
15. Wittig-Silva C, Whiting M, Lamoureux E, et al. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results. J Refract Surg 2008;24:S720-5.
16. Hoyer A, Raiskup-Wolf F, Spörl E, et al. [Collagen cross-linking with riboflavin and UVA light in keratoconus - results from Dresden]. (In German). Ophthalmologe 2009;106:133-40.
17. Raiskup-Wolf F, Hoyer A, Spoerl E, et al. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 2008;34:796-801. (Pubitemid 351615507)
18. Jankov MR 2nd, Hafezi F, Beko M, et al. [Corneal cross-linking for the treatment of keratoconus: preliminary results]. Arq Bras Oftalmol 2008;71:813-18.
19. Vinciguerra P, Albè E, Trazza S, et al. Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 2009;116:369-78.
20. Grewal DS, Brar GS, Jain R, et al. Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg 2009;35:425-32.
21. Agrawal VB. Corneal collagen cross-linking with riboflavin and ultraviolet - a light for keratoconus: results in Indian eyes. Indian J Ophthalmol 2009;57:111-14.
22. Wollensak G. Crosslinking treatment of progressive keratoconus: new hope. Curr Opin Ophthalmol 2006;17:356-60. (Pubitemid 44215044)
23. Ashwin PT, McDonnell PJ. Collagen cross-linkage: a comprehensive review and directions for future research. Br J Ophthalmol 2010;94:965-70.
24. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620-7. (Pubitemid 36457967)
25. Schanzlin DJ, Asbell PA, Burris TE, et al. The intrastromal corneal ring segments: phase II results for correction of myopia. Ophthalmology 1997;104:1067-78. (Pubitemid 27423845)
26. Nosé W, Neves RA, Burris TE, et al. Intrastromal corneal ring: 12-month sighted myopic eyes. J Refract Surg 1996;12:20-8. (Pubitemid 26051452)
27. Fleming JF, Wan WL, Schanzlin D. The theory of corneal curvature change with the intrastromal corneal ring. CLAO J 1989;2:146-50. (Pubitemid 19118465)
28. Asbell PA, Ucakhan ÖÖ, Durrie DS, et al. Adjustability of refractive effect for corneal ring segments. J Refract Surg 1999;15:627-31.
29. Burris TE, Ayer CT, Evensen DA, et al. Effects of instrastromal corneal ring size and thickness on corneal flattening in human eyes. Refract Corneal Surg 1991;7:46-50.
30. Colin J, Cochener B, Savary G, et al. Correcting keratoconus with intracorneal rings. J Cataract Refract Surg 2000;26:1117-22.
31. Colin J, Cochener B, Savary G, et al. INTACS inserts for treating keratoconus; one-year results. Ophthalmology 2001;108:1409-14. (Pubitemid 32709027)
32. Alió JL, Shabayek MH, Belda JI, et al. Analysis of results related to good and bad outcomes of Intacs implantation for keratoconus correction. J Cataract Refract Surg 2006;32:756-61. (Pubitemid 43841975)
33. Boxer Wachler BS, Chandra NS, Chou B, et al. Intacs for keratoconus. Ophthalmology 2003;110:1031-40. (Pubitemid 36560508)
34. Rabinowitz YS, Li X, Ignacio TS, et al. INTACS inserts using the femtosecond laser compared to the mechanical spreader in the treatment of keratoconus. J Refract Surg 2006;22:764-71. (Pubitemid 44595121)
35. Carrasquillo KG, Rand J, Talamo JH. Intacs for keratoconus and post-LASIK ectasia: mechanical versus femtosecond laser-assisted channel creation. Cornea 2007;26:956-62. (Pubitemid 47329801)
36. Piñero DP, Alio JL, El Kady B, et al. Refractive and aberrometric outcomes of intracorneal ring segments for keratoconus: mechanical versus femtosecond-assisted procedures. Ophthalmology 2009;116:1675-87.
37. Shabayek MH, Alió JL. Intrastromal corneal ring segment implantation by femtosecond laser for keratoconus correction. Ophthalmology 2007;114:1643-52. (Pubitemid 47332655)
38. Coskunseven E, Kymionis GD, Tsiklis NS, et al. Complications of intrastromal corneal ring segment implantation using a femtosecond laser for channel creation: a survey of 850 eyes with keratoconus. Acta Ophthalmol 2011;89:54-7.
39. Hofling-Lima AL, Branco BC, Romano AC. Corneal infections after implantation of intracorneal ring segments. Cornea 2004;23:547-9. (Pubitemid 38988692)
40. Bourcier T, Borderie V, Laroche L. Late bacterial keratitis after implantation of intrastromal corneal ring segments. J Cataract Refract Surg 2003;29:407-9. (Pubitemid 36284704)
41. McAlister JC, Ardjomand N, Ilari L, et al. Keratitis after intracorneal ring segment insertion for keratoconus. J Cataract Refract Surg 2006;32:676-8. (Pubitemid 43673858)
42. Chalasani R, Beltz J, Jhanji V, et al. Microbial keratitis following intracorneal ring segment implantation. Br J Ophthalmol 2010;94:1541.
43. Chan CC, Sharma M, Wachler BS. Effect of inferior-segment Intacs with and without C3-R on keratoconus. J Cataract Refract Surg 2007;33:75-80. (Pubitemid 44959708)
44. Venter J. Artisan phakic intraocular lens in patients with keratoconus. J Refract Surg 2009;25:759-64.
45. Kamiya K, Shimizu K, Ando W, et al. Phakic toric implantable collamer lens implantation for the correction of high myopic astigmatism in eyes with keratoconus. J Refract Surg 2008;24:840-2.
46. Navas A, Suárez R. One-year follow-up of toric intraocular lens implantation in forme fruste keratoconus. J Cataract Refract Surg 2009;35:2024-7.
47. Ghosheh FR, Cremona FA, Rapuano CJ, et al. Trends in penetrating keratoplasty in the United States 1980-2005. Int Ophthalmol 2008;28:147-53.
48. Anon. The Australian Corneal Graft Registry. 1990 to 1992 report. Aust NZ J Ophthalmol 1993;21(2 Suppl):1-48.
49. Patel HY, Ormonde S, Brookes NH, et al. The indications and outcome of paediatric corneal transplantation in New Zealand: 1991-2003. Br J Ophthalmol 2005;89:404-8.
50. Kanavi MR, Javadi MA, Sanagoo M. Indications for penetrating keratoplasty in Iran. Cornea 2007;26:561-3. (Pubitemid 47164714)
51. Wagoner MD, Gonnah el-S, Al-Towerki AE. King Khaled Eye Specialist Hospital Cornea Transplant Study Group. Outcome of primary adult penetrating keratoplasty in a Saudi Arabian population. Cornea 2009;28:882-90.
52. Guerin M, O'Connell E, Walsh C, et al. Visual outcomes and graft survival following corneal transplants: the need for an Irish National Corneal Transplant Registry. Ir J Med Sci 2008;177:107-10.
53. Bourne WM, Davison JA, O'Fallon WA. The effects of oversize donor buttons on postoperative intraocular pressure and corneal curvature in aphakic penetrating keratoplasty. Ophthalmology 1982;89:242-6. (Pubitemid 12143087)
54. Duran JA, Malvar A, Diez E. Corneal dioptric power after penetrating keratoplasty. Br J Ophthalmol 1989;73:657-60. (Pubitemid 19202079)
55. Jaycock PD, Jones MN, Males J, et al. UK Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists. Outcomes of same-sizing versus oversizing donor trephines in keratoconic patients undergoing first penetrating keratoplasty. Ophthalmology 2008;115:268-75.
56. Paglen PG, Fine M, Abbott RL, et al. The prognosis for keratoplasty in keratoconus. Ophthalmology 1982;89:651-4. (Pubitemid 12085999)
57. Sayegh FN, Ehlers N, Farah I. Evaluation of penetrating keratoplasty in keratoconus. Nine years follow-up. Acta Ophthalmol (Copenh) 1988;66:400-3.
58. Jensen LB, Hjortdal J, Ehlers N. Long-term follow-up of penetrating keratoplasty for keratoconus. Acta Ophthalmol 2010;88:347-51.
59. Lim L, Pesudovs K, Coster DJ. Penetrating keratoplasty for keratoconus: visual outcome and success. Ophthalmology 2000;107:1125-31.
60. Zadok D, Schwarts S, Marcovich A, et al. Penetrating keratoplasty for keratoconus: long-term results. Cornea 2005;24:959-61. (Pubitemid 41688530)
61. Soong HK, Malta JB. Femtosecond lasers in ophthalmology. Am J Ophthalmol 2009;147:189-97.
62. Mian SI, Shtein RM. Femtosecond laser-assisted corneal surgery. Curr Opin Ophthalmol 2007;18:295-9. (Pubitemid 46955295)
63. Kaufman HE, Werblin TP. Epikeratophakia for the treatment of keratoconus. Am J Ophthalmol 1982;93:342-7. (Pubitemid 12192857)
64. Vajpayee RB, Sharma N. Epikeratoplasty for keratoconus using manually dissected fresh lenticules: 4-year follow-up. J Refract Surg 1997;13:659-62. (Pubitemid 28012000)
65. Spitznas M, Eckert J, Frising M, et al. Long-term functional and topographic results seven years after epikeratophakia for keratoconus. Graefes Arch Clin Exp Ophthalmol 2002;240:639-43. (Pubitemid 36075624)
66. Melles GR, Lander F, Rietveld FJ, et al. A new surgical technique for deep stromal, anterior lamellar keratoplasty. Br J Ophthalmol 1999;83:327-33. (Pubitemid 29112413)
67. Melles GR, Remeijer L, Geerards AJ, et al. A quick surgical technique for deep, anterior lamellar keratoplasty using visco-dissection. Cornea 2000;19:427-32. (Pubitemid 30460873)
68. Noble BA, Agrawal A, Collins C, et al. Deep anterior lamellar keratoplasty (DALK): visual outcome and complications for a heterogeneous group of corneal pathologies. Cornea 2007;26:59-64. (Pubitemid 46041565)
69. Anwar M, Teichmann KD. Big-bubble technique to bare Descemet's membrane in anterior lamellar keratoplasty. J Cataract Refract Surg 2002;28:398-403. (Pubitemid 34208014)
70. Vajpayee RB, Tyagi J, Sharma N, et al. Deep anterior lamellar keratoplasty by big-bubble technique for treatment corneal stromal opacities. Am J Ophthalmol 2007;143:954-7.
71. Fontana L, Parente G, Tassinari G. Clinical outcomes after deep anterior lamellar keratoplasty using the big-bubble technique in patients with keratoconus. Am J Ophthalmol 2007;143:117-24.
72. Foroutan AR, Dastjerdi MH. Shifting-bubble sign in big-bubble technique in deep anterior lamellar keratoplasty. Cornea 2007;26:117. (Pubitemid 46041579)
73. Parthasarathy A, Por YM, Tan DT. Using a "small bubble technique" to aid in success in Anwar's "big bubble technique" of deep lamellar keratoplasty with complete baring of Descemet's membrane. Br J Ophthalmol 2008;92:422.
74. Fournié P, Malecaze F, Coullet J, et al. Variant of the big bubble technique in deep anterior lamellar keratoplasty. J Cataract Refract Surg 2007;33:371-5. (Pubitemid 46281551)
75. Anwar M, Teichmann KD. Deep lamellar keratoplasty: surgical techniques for anterior lamellar keratoplasty with and without baring of Descemet's membrane. Cornea 2002;21:374-83. (Pubitemid 34450473)
76. Jones MN, Armitage WJ, Ayliffe W, et al. NHSBT Ocular Tissue Advisory Group and Contributing Ophthalmologists (OTAG Audit Study 5). Penetrating and deep anterior lamellar keratoplasty for keratoconus: a comparison of graft outcomes in the United Kingdom. Invest Ophthalmol Vis Sci 2009;50:5625-9.
77. Jhanji V, Sharma N, Vajpayee RB. Intraoperative perforation of Descemet's membrane during "big bubble" deep anterior lamellar keratoplasty. Int Ophthalmol 2010;30:291-5.
78. Leccisotti A. Descemet's membrane perforation during deep anterior lamellar keratoplasty: prognosis. J Cataract Refract Surg 2007;33:825-9. (Pubitemid 46656451)
79. Sharma N, Jhanji V, Titiyal JS, et al. Use of trypan blue dye during conversion of deep anterior lamellar keratoplasty to penetrating keratoplasty. J Cataract Refract Surg 2008;34:1242-5. (Pubitemid 352014881)
80. Shimazaki J, Shimmura S, Ishioka M, et al. Randomized clinical trial of deep lamellar keratoplasty vs penetrating keratoplasty. Am J Ophthalmol 2002;134:159-65. (Pubitemid 34831817)
81. Watson SL, Ramsay A, Dart JK, et al. Comparison of deep lamellar keratoplasty and penetrating keratoplasty in patients with keratoconus. Ophthalmology 2004;111:1676-82. (Pubitemid 39179682)
82. Funnell CL, Ball J, Noble BA. Comparative cohort study of the outcomes of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus. Eye (Lond) 2006;20:527-32. (Pubitemid 43674987)
83. Al-Torbak AA, Al-Motowa S, Al-Assiri A, et al. Deep anterior lamellar keratoplasty for keratoconus. Cornea 2006;25:408-12. (Pubitemid 44620123)
84. Fogla R, Padmanabhan P. Results of deep lamellar keratoplasty using the big-bubble technique in patients with keratoconus. Am J Ophthalmol 2006;141:254-9.
85. Bahar I, Kaiserman I, Srinivasan S, et al. Comparison of three different techniques of corneal transplantation for keratoconus. Am J Ophthalmol 2008;146:905-12.
86. Feizi S, Javadi MA, Jamali H, et al. Deep anterior lamellar keratoplasty in patients with keratoconus: big-bubble technique. Cornea 2010;29:177-82.
87. Han DC, Mehta JS, Por YM, et al. Comparison of outcomes of lamellar keratoplasty and penetrating keratoplasty in keratoconus. Am J Ophthalmol 2009;148:744-51.
88. Slade SG. Applications for the femtosecond laser in corneal surgery. Curr Opin Ophthalmol 2007;18:338-41. (Pubitemid 46955302)
89. Vajpayee RB, Bhartiya P, Sharma N. Central lamellar keratoplasty with peripheral intralamellar tuck: a new surgical technique for keratoglobus. Cornea 2002;21:657-60.
90. Kaushal S, Jhanji V, Sharma N, et al. "Tuck in" lamellar keratoplasty (TILK) for corneal ectasias involving corneal periphery. Br J Ophthalmol 2008;92:286-90.
91. Springs CL, Joseph MA, Odom JV, et al. Predictability of donor lamellar graft diameter and thickness in an artificial anterior chamber system. Cornea 2002;21:696-9.
92. Busin M, Zambianchi L, Arffa RC. Microkeratome-assisted lamellar keratoplasty for the surgical treatment of keratoconus. Ophthalmology 2005;112:987-97. (Pubitemid 40797452)
93. Tan DT, Ang LP. Modified automated lamellar therapeutic keratoplasty for keratoconus: a new technique. Cornea 2006;25:1217-19. (Pubitemid 46005862)
94. Buratto L, Belloni S, Valeri R. Excimer laser lamellar keratoplasty of augmented thickness for keratoconus. J Refract Surg 1998;14:517-25. (Pubitemid 28460912)
95. Elsahn AF, Rapuano CJ, Antunes VA, et al. Excimer laser phototherapeutic keratectomy for keratoconus nodules. Cornea 2009;28:144-7.
96. Alpins N, Stamatelatos G. Customized photoastigmatic refractive keratectomy using combined topographic and refractive data for myopia and astigmatism in eyes with forme fruste and mild keratoconus. J Cataract Refract Surg 2007;33:591-602. (Pubitemid 46482956)
97. Appiotti A, Gualdi M. Treatment of keratoconus with laser in situ keratomileusis, photorefractive keratectomy, and radial keratotomy. J Refract Surg 1999;15(2 Suppl):S240-2.
98. Koller T, Iseli HP, Donitzky C, et al. Topography-guided surface ablation for forme fruste keratoconus. Ophthalmology 2006;113:2198-202. (Pubitemid 44838929)
99. Krumeich JH, Kezirian GM. Circular keratotomy to reduce astigmatism and improve vision in stage I and II keratoconus. J Refract Surg 2009;25:357-65.
100. Kanellopoulos AJ, Binder PS. Collagen cross-linking (CCL) with sequential topography-guided PRK: a temporizing alternative for keratoconus to penetrating keratoplasty. Cornea 2007;26:891-5. (Pubitemid 47220571)
101. Kymionis GD, Kontadakis GA, Kounis GA, et al. Simultaneous topography-guided PRK followed by corneal collagen cross-linking for keratoconus. J Refract Surg 2009;25:S807-11.
102. Kanellopoulos AJ. Comparison of sequential vs same-day simultaneous collagen cross-linking and topography-guided PRK for treatment of keratoconus. J Refract Surg 2009;25:S812-18.
103. Colin J, Velou S. Implantation of Intacs and a refractive intraocular lens to correct keratoconus. J Cataract Refract Surg 2003;29:832-4. (Pubitemid 36418028)
104. Kamburoǧlu G, Ertan A, Bahadir M. Implantation of Artisan toric phakic intraocular lens following Intacs in a patient with keratoconus. J Cataract Refract Surg 2007;33:528-30. (Pubitemid 46281548)
105. El-Raggal TM, Abdel Fattah AA. Sequential Intacs and Verisyse phakic intraocular lens for refractive improvement in keratoconic eyes. J Cataract Refract Surg 2007;33:966-70. (Pubitemid 46771069)
106. Coskunseven E, Onder M, Kymionis GD, et al. Combined Intacs and posterior chamber toric implantable Collamer lens implantation for keratoconic patients with extreme myopia. Am J Ophthalmol 2007;144:387-9.