Application of hollow fiber liquid phase microextraction coupled with high-performance liquid chromatography for the study of the osthole pharmacokinetics in cerebral ischemia hypoperfusion rat plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 23, 2011, Pages 2304-2310

  Zhou, Jun ^a   Zeng, Ping ^a   Cheng, Zhao Hui ^a   Liu, Jing ^a   Wang, Feng Qiao ^b   Qian, Ruo Jun ^a  

^a Urumqi General Hospital of PLA   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia reperfusion; Hollow fiber liquid phase microextraction; HPLC; Osthole; Pharmacokinetics

Indexed keywords

AGITATION RATES; CEREBRAL ISCHEMIA; CEREBRAL ISCHEMIA-REPERFUSION; EXTRACTION CONDITIONS; EXTRACTION TIME; FLUORESCENCE DETECTION; HOLLOW FIBER; HPLC; HYPOPERFUSION; LIMIT OF DETECTION; LIMIT OF QUANTIFICATIONS; LINEAR RANGE; LIQUID PHASE MICROEXTRACTION; OPTIMIZED CONDITIONS; ORAL ADMINISTRATION; OSTHOLE; PHARMACOKINETIC STUDIES; RAT PLASMA; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SALT CONCENTRATION; SAMPLE PREPARATION TECHNIQUES; VALIDATED METHODS;

BODY FLUIDS; CHROMATOGRAPHY; FIBERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OPTIMIZATION; PHARMACOKINETICS; PLASMAS; RATS; SOLVENT EXTRACTION;

LIQUIDS;

OSTHOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY; EXTRACTION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOLLOW FIBER; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID PHASE MICROEXTRACTION; MALE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CEREBRAL INFARCTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; DISEASE MODELS, ANIMAL; HUMANS; MALE; RATS; RATS, WISTAR; SOLID PHASE MICROEXTRACTION;

RATTUS;

EID: 79960566165     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.06.022     Document Type: Article

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