2D:4D ratios in the first 2years of life: Stability and relation to testosterone exposure and sensitivity

Hormones and Behavior

Volumn 60, Issue 3, 2011, Pages 256-263

  Knickmeyer, Rebecca C ^a   Woolson, Sandra ^a   Hamer, Robert M ^a,b   Konneker, Thomas ^a   Gilmore, John H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b IL   (United States)

Author keywords

2D:4D; Androgen; Digit ratio; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; DNA; TESTOSTERONE;

AGE; ANTHROPOMETRY; ARTICLE; CAG REPEAT; CHILD; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; FINGER; GENETIC POLYMORPHISM; GENOTYPE; HAND; HUMAN; INFANT; MALE; PREDICTION; PRENATAL EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; SALIVA LEVEL; SEX DIFFERENCE;

ADULT; FEMALE; FINGERS; HUMANS; INFANT; INFANT, NEWBORN; MALE; MATERNAL-FETAL EXCHANGE; POLYMORPHISM, GENETIC; PREGNANCY; RECEPTORS, ANDROGEN; SALIVA; SEX FACTORS; TESTOSTERONE;

EID: 79960562795     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2011.05.009     Document Type: Article

References (64)

1. Alexander G.M. Associations among gender-linked toy preferences, spatial ability, and digit ratio: evidence from eye-tracking analysis. Arch. Sex. Behav. 2006, 35(6):699-709.
2. Alexander G.M., Wilcox T., Farmer M.E. Hormone-behavior associations in early infancy. Horm. Behav. 2009, 56(5):498-502.
3. Allen R.C., Zoghbi H.Y., Moseley A.B., Rosenblatt H.M., Belmont J.W. Methylation of Hpaii and Hhai Sites near the Polymorphic Cag Repeat in the Human Androgen-Receptor Gene Correlates with X-Chromosome Inactivation. Am. J. Hum. Genet. 1992, 51(6):1229-1239.
4. BenHur H., Thole H.H., Mashiah A., Insler V., Berman V., Shezen E., Elias D., Zuckerman A., Ornoy A. Estrogen, progesterone and testosterone receptors in human fetal cartilaginous tissue: immunohistochemical studies. Calcif. Tissue Int. 1997, 60(6):520-526.
5. Bender R., Lange S. Adjusting for multiple testing - when and how?. J. Clin. Epidemiol. 2001, 54(4):343-349.
6. Berenbaum S.A., Bryk K.K., Nowak N., Quigley C.A., Moffat S. Fingers as a marker of prenatal androgen exposure. Endocrinology 2009, 150(11):5119-5124.
7. Bloom M.S., Houston A.S., Mills J.L., Molloy C.A., Hediger M.L. Finger bone immaturity and 2D:4D ratio measurement error in the assessment of the hyperandrogenic hypothesis for the etiology of autism spectrum disorders. Physiol. Behav. 2010, 100(3):221-224.
8. Brown W.M., Hines M., Fane B., Breedlove S.M. Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia. Horm. Behav. 2002, 42:380-386.
9. Buck J.J., Williams R.M., Hughes I.A., Acerini C.L. In-utero androgen exposure and 2nd to 4th digit length ratio - comparisons between healthy controls and females with classical congenital adrenal hyperplasia. Hum. Reprod. 2003, 18(5):976-979.
10. Burton L.A., Henninger D., Hafetz J., Cofer J. Aggression, gender-typical childhood play, and a prenatal hormonal index. Soc. Behav. Personal. 2009, 37(1):105-115.
11. Callewaert L., Christiaens V., Haelens A., Verrijdt G., Verhoeven G., Claessens F. Implications of a polyglutamine tract in the function of the human androgen receptor. Biochem. Biophys. Res. Commun. 2003, 306(1):46-52.
12. Chang C. Androgens and androgen receptor: mechanisms, functions, and clinical application 2002, Kluwer Academic Publishers, Boston.
13. Ciumas C., Hirschberg A.L., Savic I. High fetal testosterone and sexually dimorphic cerebral networks in females. Cereb. Cortex 2009, 19(5):1167-1174.
14. Csatho A., Osvath A., Bicsak E., Karadi K., Manning J.T., Kallai J. Sex role identity related to the ratio of second to fourth digit length in women. Biol. Psychol. 2003, 62(2):147-156.
15. de Bruin E.I., Verheij F., Wiegman T., Ferdinand R.F. Differences in finger length ratio between males with autism, pervasive developmental disorder-not otherwise specified, ADHD, and anxiety disorders. Dev. Med. Child. Neurol. 2006, 48(12):962-965.
16. de Vries G., Simerly R.B. Anatomy, development, and function of sexually dimorphic neural circuits in the mammalian brain. Hormones, Brain and Behavior 2002, 137-191. Academic Press, New York. D. Pfaff, A. Arnold, A. Etgen, S. Fahrbach, R. Rubin (Eds.).
17. Fechner P.Y. The biology of puberty: new developments in sex differences. Gender Differences at Puberty 2003, 17-28. Cambridge University Press, Cambridge. C. Hayward (Ed.).
18. Fink B., Manning J.T., Neave N. Second to fourth digit ratio and the 'big five' personality factors. Perspect. Individ. Differ. 2004, 37(3):495-503.
19. Fink B., Neave N., Laughton K., Manning J.T. Second to fourth digit ratio and sensation seeking. Perspect. Individ. Differ. 2006, 41(7):1253-1262.
20. Flegr J., Hrusková M., Hodnỳ Z., Hanusová J. Body height, body mass index, waist-hip ratio, fluctuating asymmetry and second to fourth digit ratio in subjects with latent toxoplasmosis. Parisitology 2005, 130(6):621-628.
21. Forest M.G., Sizonenko P.C., Cathiard A.M., Bertrand J. Hypophyso-gonadal function in humans during the first year of life: I. Evidence for testicular activity in early infancy. J. Clin. Invest. 1974, 53:819-828.
22. Galis F., Ten Broek C.M.A., Van Dongen S., Wijnaendts L.C.D. Sexual dimorphism in the prenatal digit ratio (2D:4D). Arch. Sex. Behav. 2010, 39(1):57-62.
23. Garagorri J.M., Rodriguez G., Lario-Elboj A.J., Olivares J.L., Lario-Munoz A., Orden I. Reference levels for 17-hydroxyprogesterone, 11-desoxycortisol, cortisol, testosterone, dehydroepiandrosterone sulfate and androstenedione in infants from birth to six months of age. Eur. J. Pediatr. 2007, 167(6):647-653.
24. Garn S.M., Burdi A.R., Babler W.J., Stinson S. Early prenatal attainment of adult metacarpal-phalangeal rankings and proportions. Am. J. Phys. Anthropol. 1975, 43(3):327-332.
25. Granger D.A., Cicchetti D., Rogosch F.A., Hibel L.C., Teisl M., Flores E. Blood contamination in children's saliva: prevalence, stability, and impact on the measurement of salivary cortisol, testosterone, and dehydroepiandrosterone. Psychoneuroendocrinology 2007, 32(6):724-733.
26. Grumbach M.M., Hughes I.A., Conte F.A. Williams textbook of endocrinology. Williams Textbook of Endocrinology 2003, 842-969. Saunders, Philadelphia. P. Larsen, H. Kronenberg, S. Melmed, K. Polonsky (Eds.).
27. Hampson E., Ellis C.L., Tenk C.M. On the relation between 2D: 4D and sex-dimorphic personality traits. Arch. Sex. Behav. 2008, 37(1):133-144.
28. Hickey M., Doherty D., Hart R., Norman R., Mattes E., Atkinson H., Sloboda D. Maternal and umbilical cord androgen concentrations do not predict digit ratio (2D:4D) in girls: a prospective cohort study. Psychoneuroendocrinology 2010, 35(8):1235-1244.
29. Hines M. Sexual differentiation of human brain and behavior. Hormones, Brain and Behavior 2002, 425-462. Academic Press, New York. D. Pfaff, A. Arnold, A. Etgen, S. Fahrbach, R. Rubin (Eds.).
30. Hönekopp J., Bartholdt L. Second to fourth digit length ratio (2D:4D) and adult sex hormone levels: new data and a meta-analytic review. Psychoneuroendocrinology 2007, 32:313-321.
31. Hönekopp J., Watson S. Meta-analysis of digit ratio 2D:4D shows greater sex difference in the right hand. Am. J. Hum. Biol. 2010, 22(5):619-630.
32. Irvine R.A., Ma H., Yu M.C., Ross R.K., Stallcup M.R., Coetzee G.A. Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length. Hum. Mol. Genet. 2000, 9(2):267-274.
33. Ji C., Huang X.W., Yang R.W., Wang X., Zhao Z.Y. Gonadotropins and sex hormones in healthy Chinese infants. Indian Pediatr. 2008, 45(6):489-492.
34. Kempel P., Gohlke B., Klempau J., Zinsberger P., Reuter M., Hennig J. Second-to-fourth digit length, testosterone and spatial ability. Intelligence 2005, 33(3):215-230.
35. Keogh E., Mounce C., Brosnan M. Can a sexually dimorphic index of prenatal hormonal exposure be used to examine cold pressor pain perception in men and women?. Eur. J. Pain 2007, 11(2):231-236.
36. Klump K.L., Gobrogge K.L., Perkins P.S., Thorne D., Sisk C.L., Breedlove S.M. Preliminary evidence that gonadal hormones organize and activate disordered eating. Psychol. Med. 2006, 36(4):539-546.
37. Loehlin J.C., Medland S.E., Martin N.G. Relative finger lengths, sex differences, and psychological traits. Arch. Sex. Behav. 2009, 38:298-305.
38. Lutchmaya S., Baron-Cohen S., Raggatt P., Knickmeyer R.C., Manning J.T. 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Hum. Dev. 2004, 77(1-2):23-28.
39. Malas M.A., Dogan S., Evcil E.H., Desdicioglu K. Fetal development of the hand, digits and digit ratio (2D: 4D). Early Hum. Dev. 2006, 82(7):469-475.
40. Manning J.T., Barley L., Walton J., Lewis-Jones D.I., Trivers R.L., Singh D., Thornhill R., Rohde P., Bereczkei T., Henzi P., Soler M., Szwed A. The 2nd 4th digit ratio, sexual dimorphism, population differences, and reproductive success: evidence for sexually antagonistic genes?. Evol. Hum. Behav. 2000, 21(3):163-183.
41. Manning J.T., Bundred P.E., Newton D.J., Flanagan B.F. The second to fourth digit ratio and variation in the androgen receptor gene. Evol. Hum. Behav. 2003, 24(6):399-405.
42. Manning J.T., Fink B. Digit ratio (2D:4D), dominance, reproductive success, asymmetry, and sociosexuality in the BBC Internet Study. Am. J. Hum. Biol. 2008, 20(4):451-461.
43. Manning J.T., Scutt D., Wilson J., Lewis-Jones D.I. The ratio of 2nd to 4th digit length: a predictor of sperm numbers and levels of testosterone LH and oestrogen. Hum. Reprod. 1998, 13:3000-3004.
44. Manning J.T., Stewart A., Bundred P.E., Triver R.L. Sex and ethnic differences in 2nd to 4th digit ratio of children. Early Hum. Dev. 2004, 80(2):161-168.
45. Manning J.T., Taylor R.P. Second to fourth digit ratio and male ability in sport: implications for sexual selection in humans. Evol. Hum. Behav. 2001, 22(1):61-69.
46. Martel M.M., Gobrogge K.L., Breedlove S.M., Nigg J.T. Masculinized finger-length ratios of boys, but not girls, are associated with attention-deficit/hyperactivity disorder. Behav. Neurosci. 2008, 122(2):273-281.
47. McIntyre M.H., Cohn B.A., Ellison P.T. Sex dimorphism in digital formulae of children. Am. J. Phys. Anthropol. 2006, 129(1):143-150.
48. McIntyre M.H., Ellison P.T., Lieberman D.E., Demerath E., Towne B. The development of sex differences in digital formula from infancy in the Fels Longitudinal Study. Proc. R. Soc. B Biol. Sci. 2005, 272(1571):1473-1479.
49. Millet K., Dewitte S. Second to fourth digit ratio and cooperative behavior. Biol. Psychol. 2006, 71(1):111-115.
50. Munoz A., Rosner B., Carey V. Regression-analysis in the presence of heterogeneous intraclass correlations. Biometrics 1986, 42(3):653-658.
51. Okten A., Kalyoncu M., Yaris N. The ratio of second- and fourth-digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Early Hum. Dev. 2002, 70:47-54.
52. Rahman Q., Wilson G.D. Sexual orientation and the 2nd to 4th finger length ratio: evidence for organising effects of sex hormones or developmental instability?. Psychoneuroendocrinology 2003, 28(3):288-303.
53. Romano M., Leoni B., Saino N. Examination marks of male university students positively correlate with finger length ratios (2D:4D). Biol. Psychol. 2006, 71(2):175-182.
54. Scarbrough P.S., Johnston V.S. Individual differences in women's facial preferences as a function of digit ratio and mental rotation ability. Evol. Hum. Behav. 2005, 26(6):509-526.
55. Schwartz E.B., Granger D.A. Transferrin enzyme immunoassay for quantitative monitoring of blood contamination in saliva. Clin. Chem. 2004, 50(3):654-656.
56. Shirtcliff E.A., Granger D.A., Likos A. Gender differences in the validity of testosterone measured in saliva by immunoassay. Horm. Behav. 2002, 42(1):62-69.
57. Simerly R.B. Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain. Ann. Rev. Neurosci. 2002, 25:507-536.
58. Smith A., Hawkeswood B., Joiner T. The measure of a man: associations between digit ratio and disordered eating in males. Int. J. Eat Disord. 2010, 43(6):543-548.
59. Smith L.L., Hines M. Language lateralization and handedness in women prenatally exposed to diethylstilbestrol (DES). Psychoneuroendocrinology 2000, 25:497-512.
60. van de Beek C., Thijssen J.H.H., Cohen-Kettenis P.T., van Goozen S.H.M., Buitelaar J.K. Relationships between sex hormones assessed in amniotic fluid, and maternal and umbilical cord serum: what is the best source of information to investigate the effects of fetal hormonal exposure?. Horm. Behav. 2004, 46(5):663-669.
61. Voracek M., Loibl L.M. Scientometric analysis and bibliography of digit ratio (2d:4d) research, 1998-2008. Psychol. Report 2009, 104(3):922-956.
62. Walder D.J., Andersson T.L.C., McMillan A.L., Breedlove S.M., Walker E.F. Sex differences in digit ratio (2D:4D) are disrupted in adolescents with schizotypal personality disorder: altered prenatal gonadal hormone levels as a risk factor. Schizophr. Res. 2006, 86(1-3):118-122.
63. Wallien M.S.C., Zucker K.J., Steensma T.D., Cohen-Kettenis P.T. 2D:4D finger-length ratios in children and adults with gender identity disorder. Horm. Behav. 2008, 54(3):450-454.
64. Williams J.H.G., Greenhalgh K.D., Manning J.T. Second to fourth finger ratio and possible precursors of developmental psychopathology in preschool children. Early Hum. Dev. 2003, 72:57-65.