Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black men

Metabolism: Clinical and Experimental

Volumn 60, Issue 8, 2011, Pages 1178-1185

  Miljkovic, Iva ^a   Cauley, Jane A ^a   Dressen, Amy S ^a   Gordon, Christopher L ^b   Goodpaster, Bret H ^c   Kuller, Lewis H ^a   Bunker, Clareann H ^a   Patrick, Alan L ^d   Wheeler, Victor W ^d   Orwoll, Eric S ^e   Zmuda, Joseph M ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d Tobago Health Studies Office   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTANOLONE; ESTROGEN; TESTOSTERONE;

ADULT; AGED; ANDROGEN BLOOD LEVEL; ARTICLE; BODY FAT DISTRIBUTION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; ESTROGEN BLOOD LEVEL; GASTROCNEMIUS MUSCLE; GLUCURONIDATION; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; NEGRO; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE; SUBCUTANEOUS FAT; TESTOSTERONE BLOOD LEVEL;

ADIPOSITY; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; AGED, 80 AND OVER; AGING; ANDROGENS; BODY COMPOSITION; BODY MASS INDEX; HUMANS; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; OVERWEIGHT; TRINIDAD AND TOBAGO;

EID: 79960558651     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2010.12.014     Document Type: Article

References (60)

1. Brancati F.L., Kao W.H., and Folsom A.R. Incident type 2 diabetes mellitus in African American and white adults: the Atherosclerosis Risk in Communities Study JAMA 283 2000 2253 2259 (Pubitemid 30246776)
2. Marcus M.A., Murphy L., and Pi-Sunyer F.X. Insulin sensitivity and serum triglyceride level in obese white and black women: relationship to visceral and truncal subcutaneous fat Metabolism 48 1999 194 199 (Pubitemid 29072274)
3. Ryan A.S., Nicklas B.J., and Berman D.M. Racial differences in insulin resistance and mid-thigh fat deposition in postmenopausal women Obes Res 10 2002 336 344 (Pubitemid 135688243)
4. Despres J.P., Couillard C., and Gagnon J. Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study Arterioscler Thromb Vasc Biol 20 2000 1932 1938 (Pubitemid 30644643)
5. Conway J.M., Yanovski S.Z., and Avila N.A. Visceral adipose tissue differences in black and white women Am J Clin Nutr 61 1995 765 771
6. Hill J.O., Sidney S., and Lewis C.E. Racial differences in amounts of visceral adipose tissue in young adults: the CARDIA (Coronary Artery Risk Development in Young Adults) study Am J Clin Nutr 69 1999 381 387 (Pubitemid 29104556)
7. Lovejoy J.C., de la Bretonne J.A., and Klemperer M. Abdominal fat distribution and metabolic risk factors: effects of race Metabolism 45 1996 1119 1124 (Pubitemid 26300311)
8. Ding J., Visser M., and Kritchevsky S.B. The association of regional fat depots with hypertension in older persons of white and African American ethnicity Am J Hypertens 17 2004 971 976 (Pubitemid 39361671)
9. Miljkovic IandZmuda J.M. Epidemiology of myosteatosis Curr Opin Clin Nutr Metab Care 13 2010 260 264
10. Miljkovic I., Cauley J.A., and Petit M.A. Greater adipose tissue infiltration in skeletal muscle among older men of African ancestry J Clin Endocrinol Metab 94 2009 2735 2742
11. Rodriguez A., Muller D.C., and Metter E.J. Aging, androgens, and the metabolic syndrome in a longitudinal study of aging J Clin Endocrinol Metab 92 2007 3568 3572 (Pubitemid 47435336)
12. Blouin K., Veilleux A., and Luu-The V. Androgen metabolism in adipose tissue: recent advances Mol Cell Endocrinol 301 2009 97 103
13. Traish A.M., Saad F., and Guay A. The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance J Androl 30 2009 23 32
14. Gapstur S.M., Gann P.H., and Kopp P. Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study Cancer Epidemiol Biomarkers Prev 11 2002 1041 1047 (Pubitemid 35192655)
15. Ding E.L., Song Y., and Malik V.S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis JAMA 295 2006 1288 1299
16. Labrie F. Intracrinology Mol Cell Endocrinol 78 1991 C113 C118
17. Labrie F., Belanger A., and Belanger P. Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women J Steroid Biochem Mol Biol 99 2006 182 188 (Pubitemid 43766081)
18. Bunker C.H., Patrick A.L., and Konety B.R. High prevalence of screening-detected prostate cancer among Afro-Caribbeans: the Tobago Prostate Cancer Survey Cancer Epidemiol Biomarkers Prev 11 2002 726 729 (Pubitemid 34851906)
19. Labrie F., Cusan L., and Gomez J.L. Comparable amounts of sex steroids are made outside the gonads in men and women: strong lesson for hormone therapy of prostate and breast cancer J Steroid Biochem Mol Biol 113 2009 52 56
20. Sodergard R., Backstrom T., and Shanbhag V. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature J Steroid Biochem 16 1982 801 810 (Pubitemid 13228095)
21. Simonsick E.M., Maffeo C.E., and Rogers S.K. Methodology and feasibility of a home-based examination in disabled older women: the Women's Health and Aging Study J Gerontol A Biol Sci Med Sci 52 1997 M264 M274
22. Goodpaster B.H., Kelley D.E., and Thaete F.L. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content J Appl Physiol 89 2000 104 110 (Pubitemid 30482569)
23. Bondar R.J., and Mead D.C. Evaluation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides in the hexokinase method for determining glucose in serum Clin Chem 20 1974 586 590
24. Matthews D.R., Hosker J.P., and Rudenski A.S. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419 (Pubitemid 15018832)
25. Miljkovic-Gacic I., Gordon C.L., and Goodpaster B.H. Adipose tissue infiltration in skeletal muscle: age patterns and association with diabetes among men of African ancestry Am J Clin Nutr 87 2008 1590 1595 (Pubitemid 351872618)
26. Haffner S.M., Karhapaa P., and Mykkanen L. Insulin resistance, body fat distribution, and sex hormones in men Diabetes 43 1994 212 219 (Pubitemid 24033674)
27. Haffner S.M., Valdez R.A., and Stern M.P. Obesity, body fat distribution and sex hormones in men Int J Obes Relat Metab Disord 17 1993 643 649 (Pubitemid 23340277)
28. Osuna J.A., Gomez-Perez R., and Arata-Bellabarba G. Relationship between BMI, total testosterone, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men Arch Androl 52 2006 355 361 (Pubitemid 44174454)
29. Seidell J.C., Bjorntorp P., and Sjostrom L. Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels Metabolism 39 1990 897 901 (Pubitemid 20293933)
30. Vandenput L., Mellstrom D., and Lorentzon M. Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men J Clin Endocrinol Metab 92 2007 4130 4137 (Pubitemid 350074722)
31. Woodhouse L.J., Gupta N., and Bhasin M. Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men J Clin Endocrinol Metab 89 2004 718 726 (Pubitemid 38269883)
32. Joyner J., Hutley L., and Cameron D. Intrinsic regional differences in androgen receptors and dihydrotestosterone metabolism in human preadipocytes Horm Metab Res 34 2002 223 228 (Pubitemid 34666583)
33. Pasquali R., Casimirri F., and Cantobelli S. Effect of obesity and body fat distribution on sex hormones and insulin in men Metabolism 40 1991 101 104
34. Colangelo L.A., Ouyang P., and Liu K. Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: multi-ethnic study of atherosclerosis Diabetes Care 32 2009 1049 1051
35. Stellato R.K., Feldman H.A., and Hamdy O. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study Diabetes Care 23 2000 490 494 (Pubitemid 30185792)
36. Oh J.Y., Barrett-Connor E., and Wedick N.M. Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study Diabetes Care 25 2002 55 60 (Pubitemid 41070783)
37. Pitteloud N., Hardin M., and Dwyer A.A. Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men J Clin Endocrinol Metab 90 2005 2636 2641 (Pubitemid 40686302)
38. Peters J.M., Zhou Y.C., and Ram P.A. Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate Mol Pharmacol 50 1996 67 74 (Pubitemid 26250076)
39. Malkin C.J., Pugh P.J., and Jones R.D. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men J Clin Endocrinol Metab 89 2004 3313 3318 (Pubitemid 38951897)
40. Chen R.Y., Wittert G.A., and Andrews G.R. Relative androgen deficiency in relation to obesity and metabolic status in older men Diabetes Obes Metab 8 2006 429 435 (Pubitemid 44349235)
41. Tchernof A., Despres J.P., and Dupont A. Relation of steroid hormones to glucose tolerance and plasma insulin levels in men. Importance of visceral adipose tissue Diabetes Care 18 1995 292 299
42. Tchernof A., Labrie F., and Belanger A. Androstane-3alpha,17beta-diol glucuronide as a steroid correlate of visceral obesity in men J Clin Endocrinol Metab 82 1997 1528 1534 (Pubitemid 27200430)
43. Pritchard J., Despres J.P., and Gagnon J. Plasma adrenal, gonadal, and conjugated steroids before and after long-term overfeeding in identical twins J Clin Endocrinol Metab 83 1998 3277 3284 (Pubitemid 28500972)
44. Pritchard J., Despres J.P., and Gagnon J. Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins Metabolism 48 1999 1120 1127 (Pubitemid 29418281)
45. Goodman-Gruen D., and Barrett-Connor E. Sex hormone-binding globulin and glucose tolerance in postmenopausal women. The Rancho Bernardo Study Diabetes Care 20 1997 645 649 (Pubitemid 27143431)
46. Haffner S.M., Katz M.S., and Dunn J.F. Increased upper body and overall adiposity is associated with decreased sex hormone binding globulin in postmenopausal women Int J Obes 15 1991 471 478
47. Ding E.L., Song Y., and Manson J.E. Sex hormone-binding globulin and risk of type 2 diabetes in women and men N Engl J Med 361 2009 1152 1163
48. Plymate S.R., Matej L.A., and Jones R.E. Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin J Clin Endocrinol Metab 67 1988 460 464
49. Zumoff B., Miller L.K., and Strain G.W. Reversal of the hypogonadotropic hypogonadism of obese men by administration of the aromatase inhibitor testolactone Metabolism 52 2003 1126 1128 (Pubitemid 37203485)
50. Strain G.W., Zumoff B., and Miller L.K. Effect of massive weight loss on hypothalamic-pituitary-gonadal function in obese men J Clin Endocrinol Metab 66 1988 1019 1023
51. Vermeulen A., Kaufman J.M., and Giagulli V.A. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males J Clin Endocrinol Metab 81 1996 1821 1826 (Pubitemid 26152470)
52. K.T. Khaw, and Barrett-Connor E. Endogenous sex hormones, high density lipoprotein cholesterol, and other lipoprotein fractions in men Arterioscler Thromb 11 1991 489 494
53. Tsai E.C., Matsumoto A.M., and Fujimoto W.Y. Association of bioavailable, free, and total testosterone with insulin resistance Diabetes Care 27 2004 861 868
54. Blouin K., Boivin A., and Tchernof A. Androgens and body fat distribution J Steroid Biochem Mol Biol 108 2008 272 280 (Pubitemid 351179628)
55. Gupta V., Bhasin S., and Guo W. Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes Mol Cell Endocrinol 296 2008 32 40
56. Goodpaster B.H., Krishnaswami S., and Resnick H. Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women Diabetes Care 26 2003 372 379 (Pubitemid 36929058)
57. Gan S.K., Samaras K., and Thompson C.H. Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy Diabetes 51 2002 3163 3169 (Pubitemid 35246961)
58. K.F. Petersen, and Shulman G.I. Etiology of insulin resistance Am J Med 119 2006 S10 S16
59. Timmers S., and Schrauwen Pandde Vogel J. Muscular diacylglycerol metabolism and insulin resistance Physiol Behav 94 2008 242 251 (Pubitemid 351615425)
60. Vettor R., Milan G., and Franzin C. The origin of intermuscular adipose tissue and its pathophysiological implications Am J Physiol Endocrinol Metab 297 2009 E987 E998