N-Acetylaspartylglutamate is an agonist at mGluR3 in vivo and in vitro

Journal of Neurochemistry

Volumn 119, Issue 5, 2011, Pages 891-895

  Neale, Joseph H ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

glutamate carboxypeptidase; metabotropic glutamate receptors; mGluR3; N acetylaspartylglutamate; NAAG; neurotransmitter

Indexed keywords

ENZYME INHIBITOR; G PROTEIN DEPENDENT POTASSIUM CHANNEL; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; N ACETYLASPARTYLGLUTAMIC ACID; N ACETYLASPARTYLGLUTAMIC ACID PEPTIDASE; N ACETYLASPARTYLGLUTAMIC ACID PEPTIDASE INHIBITOR; PEPTIDASE; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

BIOSYNTHESIS; CEREBELLUM GRANULE CELL; GRANULE CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVIEW; SCHIZOPHRENIA; SYNAPSE;

ANIMALS; DIPEPTIDES; HUMANS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 79960558038     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07380.x     Document Type: Review

References (29)

1. Adedoyin M. O., Vicini S., and, Neale J. H., (2010) Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model. Mol. Pain 6, 60.
2. Ambrosio M., Zurn A., and, Lohse M., (2011) Sensing G protein-coupled protein activation. Neuropharmacology 60, 45-51.
3. Bischofberger J., and, Schild D., (1996) Glutamate and N-acetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via a mGluR2/3-like receptor. J. Neurophysiol. 76, 2089-2092. (Pubitemid 26322643)
4. Chopra M., Yao Y., Blake T. J., Hampson D. R., and, Johnson E. C., (2009) The neuroactive peptide N-acetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptor. J. Pharmacol. Exp. Ther. 330, 212-9.
5. Fricker A. C., Mok M. H., de la Flor R., Shah A. J., Woolley M., Dawson L. A., and, Kew J. N., (2009) Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR. Neuropharmacology 56, 1060-7.
6. Ghose S., Wroblewska B., Corsi L., Grayson D., DeBlas A. L., Vicini S., and, Neale J. H., (1997) NAAG stimulates mGluR3 to regulate expression of the GABA-A alpha-6 subunit in cerebellar granule cells. J. Neurochem. 69, 2326-2335. (Pubitemid 27495417)
7. Lea P. M., Wroblewska B., Sarvey J. M., and, Neale J. H., (2001) β-NAAG rescues LTP from blockade by NAAG in the rat dentate gyrus via the type 3 metabotropic glutamate receptor. J. Neurophys. 85, 1097-1106. (Pubitemid 32209597)
8. Lee C. C., and, Sherman S. M., (2009) Glutamatergic inhibition in sensor neocortex. Cereb. Cortex 19, 2281-2289.
9. Lodder-Gadaczek J., Becker I., Gieselmann V., Wang-Eckhardt L., and, Eckhardt M., (2011) N-Acetylaspartylglutamate synthetase-II synthesizes N-acetylaspartyl-glutamylglutamate. J. Biol. Chem. 286, 16693-16706.
10. Losi G., Vicini S., and, Neale J., (2004) NAAG fails to antagonize synaptic and extrasynaptic NMDA receptors in cerebellar granule neurons. Neuropharmacology 46, 490-496. (Pubitemid 38224434)
11. Nan F., Bzdega T., Pshenichkin S., Wroblewski J. T., Wroblewska B., Neale J. H., and, Kozikowski A. P., (2000) Dual function glutamate-related ligands: discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR2 agonist activity. J. Med. Chem. 43, 772-774. (Pubitemid 30152285)
12. Neale J. H., Bzdega T., and, Wroblewska B., (2000) N- Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J. Neurochem. 75, 443-52. (Pubitemid 30485424)
13. Neale J. H., Olszewski R. T., Gehl L. M., Wroblewska B., and, Bzdega T., (2005) The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia. Trends Pharmacol. Sci. 26, 477-84. (Pubitemid 41207880)
14. Neale J. H., Olszewski R. T., Zuo D., Janczura K. J., Lavin K. M., Madore J. C., Profaci C. P., and, Bzdega T., (2011) Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family. J. Neurochem. 118, 490-498.
15. Niswender C. M., and, Conn P. J., (2010) Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu. Rev. Pharmacol. Toxicol. 50, 295-322.
16. Schweitzer C., Kratzeisen C., Adam G., Lundstrom K., Malherbe P., Ohresser S., Stadler H., Wichmann J., Woltering T., and, Mutel V., (2000) Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki forest virus vectors. Neuropharmacology 39, 1700-1706. (Pubitemid 30398475)
17. Silva R., Mata L. R., Gulbenkian S., Brito M. A., Tiribelli C., and, Brites D., (1999) Inhibition of glutamate uptake by unconjugated bilirubin in cultured cortical rat astrocytes: Role of concentration and pH. Biochem. Biophys. Res. Comm. 265, 67-72.
18. Slusher B. S., Vornov J. J., Thomas A. G., et al. (1999) Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat. Med. 5, 1396-402.
19. Tsukamoto T., Wozniak K. M., and, Slusher B. S., (2007) Progress in the discovery and development of glutamate carboxypeptidase II inhibitors. Drug Discov. Today 12, 767-76. (Pubitemid 47362787)
20. Wroblewska B., Wroblewski J. T., Saab O., and, Neale J. H., (1993) N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells. J. Neurochem. 61, 943-948. (Pubitemid 23241231)
21. Wroblewska B., Wroblewski J. T., Pshenichkin S., Surin A., Sullivan S. E., and, Neale J. H., (1997) N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J. Neurochem. 69, 174-182.
22. Wroblewska B., Santi M. R., and, Neale J. H., (1998) N- Acetylaspartylglutamate activates cyclic-AMP coupled metabotropic glutamate receptors in cerebellar astrocytes. Glia 24, 172-180.
23. Wroblewska B., Wegorzewska I. N., Bzdega T., Olszewski R. T., and, Neale J. H., (2006) Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes. J. Neurochem. 96, 1071-7.
24. Yamamoto T., Hirasawa S., Wroblewska B., Zhou J., Grajkowska E., Kozikowski A., Wroblewski J., and, Neale J. H., (2004) Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. Eur. J. Neurosci., 20, 483-494. (Pubitemid 38969633)
25. Yamamoto T., Saito O., Aoe T., Bartolozzi A., Sarva J., Zhou J., Kozikowski A., Wroblewska B., Bzdega T., and, Neale J. H., (2007) Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur. J. Neurosci. 25, 147-58. (Pubitemid 46098894)
26. Yamamoto T., Kozikowski A., Zhou J., and, Neale J. H., (2008) Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain. Mol. Pain 4, 31.
27. Zhao J., Ramadan E., Cappiello M., Wroblewska B., Bzdega T., and, Neale J. H., (2001) NAAG inhibits KCl-induced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance. Eur. J. Neurosci 13, 340-346. (Pubitemid 32142478)
28. Zhong C., Zhao X., Van K. C., et al. (2006) NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat. J. Neurochem. 97, 1015-25.
29. Zhou J., Neale J. H., Pomper M. G., and, Kozikowski A. P., (2005) NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat. Rev. Drug Discov. 4, 1015-1026.