Analysis of the T-cell receptor repertoire in human atherosclerosis

Cardiovascular Research

Volumn 36, Issue 2, 1997, Pages 256-267

  Oksenberg, Jorge R ^a   Stavri, George T ^b   Jeong, Matthew C ^a   Natara Garovoy, ^a   Salisbury, Jonathan R ^b   Erusalimsky, Jorge D ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aorta; Atherosclerosis; Gene expression; Human; T cell receptor; T lymphocytes

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ARTICLE; ATHEROSCLEROSIS; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LYMPHOCYTIC INFILTRATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; T LYMPHOCYTE; THORACIC AORTA;

AORTA, THORACIC; ARTERIOSCLEROSIS; GENE EXPRESSION; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, T-CELL RECEPTOR BETA; HUMANS; LEUKOCYTES, MONONUCLEAR; POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC;

EID: 0031281320     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(97)00129-6     Document Type: Article

References (50)

1. Jonasson L., Holm J., Skalli O., Bondjers G., Hansson K. Regional accumulation of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis. 6:1986;131-138.
2. Hansson G.K. Immune and inflammatory mechanisms in the development of atherosclerosis. Br Heart J. 69(suppl):1993;S38-S41.
3. Xu Q., Oberhuber G., Gruschwitz M., Wick G. Immunology of atherosclerosis: Cellular composition and MHC class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens. Clin Immunol Immunopathol. 56:1990;344-359.
4. Hansson G.K., Jonasson L., Holm J., Claesson-Welsh L. Class II MHC antigen expression in atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain. Clin Exp Immunol. 64:1986;261-268.
5. Hansson G.K., Jonasson L., Seifert P.S., Stemme S. Immune mechanisms in atherosclerosis. Arteriosclerosis. 9:1989;567-578.
6. Hansson G.K., Holm J., Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol. 135:1989;169-175.
7. Stemme S., Holm J., Hansson G.K. T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1. Arterioscler Thromb. 12:1992;206-211.
8. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
9. Wick G., Schett G., Amberger A., Kleindienst R., Xu Q. Is atherosclerosis an immunologically mediated disease? Immunol Today. 16:1995;27-33.
10. Xu Q., Willeit J., Marosi M.et al. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet. 341:1993;255-259.
11. Stemme S., Faber B., Holm J., Wiklund O., Witztum J.L., Hansson G.K. T lymphocytes from human atherosclerotic plaques recognize oxidized low density protein. Proc Natl Acad Sci USA. 92:1995;3893-3897.
12. Mattila K.J., Valle M.S., Nieminen M.S., Valtonen V.V., Hietaniemi K.L. Dental infections and coronary atherosclerosis. Atherosclerosis. 103:1993;205-211.
13. Thom D., Grayston T., Siscovick D.S., Wang S.P., Weiss N.S., Daling J.R. Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease. J Am Med Assoc. 268:1992;68-72.
14. Bruggeman C.A., Dam-Mieras V. The possible role of cytomegalovirus in atherogenesis. Prog Med Virol. 38:1991;1-26.
15. Yamashiroya H.M., Ghosh L., Yang R.et al. Herpesviridae in coronary vessels and aorta of young trauma victims. Am J Pathol. 130:1988;71-79.
16. Oksenberg J.R., Stuart S., Begovich A.B.et al. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature. 345:1990;344-346.
17. Oksenberg JR, Panzara MA, Steinman L. The polymerase chain reaction and the analysis of the T cell receptor repertoire. Austin, TX: RG Landes Company, 1992.
18. Marguerie C., Lunardi C., So A. PCR-based analysis of the TCR repertoire in human autoimmune diseases. Immunol Today. 13:1992;336-338.
19. Karin N., Szafer F., Mitchell D., Gold D.P., Steinman L. Selective and non selective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis. J Immunol. 150:1993;4116-4124.
20. Jorgensen J.L., Esser U., Fazekas de St. Groth B., Reay P., Davis M.M. Mapping TCR-peptide contacts by variant peptide immunization of single-chain transgenics. Nature. 355:1992;224-230.
21. Katayama C.D., Eidelman F.J., Duncan A., Hooshmand F., Hedrick S.M. Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity. EMBO J. 14:1995;927-938.
22. Garboczi D.N., Ghosh P., Utz U., Fan Q.R., Biddison W.E., Wiley D.C. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature. 384:1996;134-141.
23. Oksenberg J.R., Panzara M.A., Begovich A.B.et al. Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature. 362:1993;68-70.
24. Stemme S., Rymo L., Hansson G.K. Polyclonal origin of T lymphocytes in human atherosclerotic plaques. Lab Invest. 65:1991;654-660.
25. Swanson S.J., Rosenzweig A., Seidman J.G., Libby P. Diversity of T cell antigen receptor V beta gene utilization in advanced human atheroma. Arterioscler Thromb. 14:1994;1210-1214.
26. Stary H.C., Chandler A.B., Glagov S. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. Arterioscler Thromb. 14:1994;840-856.
27. Stary H.C., Chandler A.B., Dinsmore R.E. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. Circulation. 92:1995;1355-1374.
28. D'Aquila R.T., Bechtel L.J., Videler J.A., Eron J.J., Gorczyca P., Kaplan J.C. Maximizing sensitivity and specificity of PCR by preamplification heating. Nucleic Acid Res. 19:1991;3749.
29. Oksenberg JR, Steinman L. Detection an analysis of T cell receptor gene products by RT-PCR. In: Siebert PD, Larrick JW, editors. Reverse transcriptase PCR. London: Ellis Horwood, 1995:61-85.
30. Lazaro A.M., Fernandez-Vina M.A., Liu Z., Stastny P. Enzyme-linked DNA oligotyping. A practical method for clinical HLA-DNA typing. Hum Immunol. 36:1993;243-248.
31. Holodniy M., Winters M.A., Merigan T.C. Detection and quantitation of gene amplification products by a nonisotopic automated system. BioTechniques. 12:1992;36-39.
32. Gorski J., Yassai M., Kissella B., Keever C., Flomenberg N. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. J Immunol. 152:1994;5109-5119.
33. Lehman EL, D'Abrera HJM. Non parametrics statistical methods based on ranks. New York: McGraw Hill, 1975.
34. Rosenberg W.M.C., Moss P.A.H., Bell J.I. Variation in human T cell receptor V beta and J beta repertoire: analysis using anchor polymerase chain reaction. Eur J Immunol. 22:1992;541-549.
35. Akolkar P.N., Gulwani-Akolkar B., Pergolizzi R., Bigler R.D., Silver J. Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes. J Immunol. 150:1993;2761-2773.
36. Ramakrishnan N.S., Grunewald J., Janson C.H., Wigzell H. Nearly identical T-cell receptor V-gene usage at birth in two cohorts of distinctly different ethnic origin: influence of environment in the final maturation in the adult. Scand J Immunol. 36:1992;71-78.
37. Hall M.A., Lanchbury J.S. Healthy human T-cell receptor beta chain repertoire. Hum Immunol. 43:1995;207-218.
38. Shanmugam A., Copie-Bergman C., Falissard B. TCR alpha beta gene usage for myelin basic protein recognition in healthy monozygous twins. J Immunol. 156:1996;3747-3754.
39. Steinberg D. Modified forms of low-density lipoprotein and atherosclerosis. J Intern Med. 233:1993;227-232.
40. Haliwell B. The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis. 231:1993;118-126.
41. Jonasson L., Holm J., Hansson G.K. Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury. Proc Natl Acad Sci USA. 85:1988;2303-2306.
42. Drew A.F., Tipping P.G. Cyclosporin treatment reduces early atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis. 116:1995;181-189.
43. Roselaar S.E., Schonfeld G., Daugherty A. Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell mediated immunity. J Clin Invest. 96:1995;1389-1394.
44. Emeson E.E., Shen M.-L. Accelerated atherosclerosis in hyperlipidemic C57BL/6 mice treated with cyclosporin A. Am J Pathol. 142:1993;1906-1915.
45. Hansson G.K., Holm J., Holm S., Fotev Z., Hedrich H., Fingerle J. T lymphocytes inhibit the vascular response to injury. Proc Natl Acad Sci USA. 88:1991;10530-10534.
46. Fyfe A.I., Qiao J.-H., Lusis A.J. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest. 94:1994;2516-2520.
47. Thyberg J., Hansson G.K. Cyclosporin A inhibits induction of DNA synthesis by PDGF and other peptide mitogens in cultured rat aortic smooth muscle cells and dermal fibroblasts. Growth Factors. 4:1991;209-219.
48. McMurray H.F., Parthasarathy D., Steinberg D. Oxidatively modified low density lipoprotein is a chemoattractant for human T-lymphocytes. J Clin Invest. 92:1993;1004-1008.
49. Breslow J.L. Mouse models of atherosclerosis. Science. 272:1996;685-688.
50. Callow M.J., Verstuyft J., Tanirala R., Palinski W., Rubin E.M. Atherogenesis in transgenic mice with human apolipoprotein B and lipoprotein(a). J Clin Invest. 96:1995;1639-1646.