In vitro determination of the effect of Andrographis paniculata extracts and andrographolide on human hepatic cytochrome P450 activities

Journal of Natural Medicines

Volumn 65, Issue 3-4, 2011, Pages 440-447

  Pan, Yan ^a   Abd Rashid, Badrul Amini ^b   Ismail, Zakiah ^b   Ismail, Rusli ^c   Mak, Joon Wah ^a   Pook, Peter C K ^a   Er, Hui Meng ^a   Ong, Chin Eng ^d  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b INSTITUTE FOR MEDICAL RESEARCH   (Malaysia)

^c INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE INFORMM   (Malaysia)

^d MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

Acanthaceae; Andrographis paniculata; Andrographolide; Cytochrome P450; Drug herb interaction; In vitro

Indexed keywords

ALCOHOL; ANDROGRAPHIS PANICULATA EXTRACT; ANDROGRAPHOLIDE; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; HEXANE; METHANOL; TESTOSTERONE; TOLBUTAMIDE;

AQUEOUS SOLUTION; ARTICLE; DEMETHYLATION; DRUG HYDROXYLATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN;

ANDROGRAPHIS; ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DITERPENES; HUMANS; LIVER; PLANT EXTRACTS;

EID: 79960470564     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-011-0516-z     Document Type: Article

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