Vascular depression in the elderly. Does inflammation play a role?;La depressione vascolare nell'anziano. Quale ruolo per l'infiammazione?

Recenti Progressi in Medicina

Volumn 102, Issue 6, 2011, Pages 261-266

  Viscogliosi, Giovanni ^a   Andreozzi, Paola ^a   Chiriac, Iulia Maria ^a   Ettorre, Evaristo ^a   Vulcano, Achiropita ^a   Servello, Adriana ^a   Marigliano, Benedetta ^a   Marigliano, Vincenzo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Anti inflammatory drugs; Chronic inflammation; Depression; Elderly; Vascular disease

Indexed keywords

CYTOKINE; GLUCOCORTICOID; PSYCHOTROPIC AGENT;

ANTIINFLAMMATORY ACTIVITY; BRAIN DAMAGE; CHRONIC INFLAMMATION; CLINICAL STUDY; CONCENTRATION (PARAMETERS); DEPRESSION; DISEASE ASSOCIATION; ELDERLY CARE; EXPERIMENTAL STUDY; HUMAN; METABOLIC SYNDROME X; REVIEW; SEROTONINERGIC SYSTEM; VASCULAR DISEASE;

AGED; AGING; ANTI-INFLAMMATORY AGENTS; ATHEROSCLEROSIS; BODY MASS INDEX; BRAIN; CARDIOVASCULAR DISEASES; CYTOKINES; DEPRESSIVE DISORDER; DRUG THERAPY, COMBINATION; EVIDENCE-BASED MEDICINE; GLUCOCORTICOIDS; HUMANS; INFLAMMATION; METABOLIC SYNDROME X; PSYCHOTROPIC DRUGS; RISK FACTORS; TREATMENT OUTCOME;

EID: 79960467177     PISSN: 00341193     EISSN: 20381840     Source Type: Journal    
DOI: None     Document Type: Review

References (21)

1. Blazer D. Depression in the elderly. N Engl J Med 1989; 320: 164-6.
2. Lebowitz BD, Pearson JL, Schneider LS, et al. Diagnosis and treatment of depression in late life. Consensus statement update. JAMA1997; 278: 1186-90.
3. O'Connell H, Chin AV, Cunningham C, Lawlor BA. Recent developments: suicide in older people. BMJ 2004; 329: 895-9. (Pubitemid 39422935)
4. Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet 2007; 370: 851-8. (Pubitemid 47362344)
5. Alexopoulos GS. New concepts for prevention and treatment of late-life depression. Am J Psychiatry 2001; 158: 835.
6. Artero S, Tiemeier H, Prins ND, Sabatier R, Breteler MM, Ritchie K. Neuroanatomical localisation and clinical correlates of white matter lesions in the elderly. J Neurol Neurosurg Psychiatry 2004; 75: 1304-8. (Pubitemid 39141339)
7. Verdelho A, Hénon H, Lebert F, Pasquier F, Leys D. Depressive symptoms after stroke and relationship with dementia: a three-year follow-up study. Neurology 2004; 62: 905-11. (Pubitemid 38435777)
8. Zisook S, Lesser I, Stewart JW, et al. Effect of age at onset on the course of major depressive disorder.Am J Psychiatry 2007; 164: 1539-46.
9. Gump BB, Matthews KA, Eberly LE, Chang YF; MRFIT Research Group. Depressive symptoms and mortality in men: results from the multiple risk factor intervention trial. Stroke 2005; 36: 98-102. (Pubitemid 40054182)
10. Stewart RA, North FM, West TM, et al. Depression and cardiovascular morbidity and mortality: cause or consequence? Eur Heart J 2003; 24: 2027-37.
11. Tiemeier H, van Dijck W, Hofman A, Witteman JC, Stijnen T, Breteler MM. Relationship between atherosclerosis and late-life depression: the Rotterdam Study. Arch Gen Psychiatry 2004; 61: 369-76. (Pubitemid 38451546)
12. Vinkers DJ, Stek ML, van der Mast RC, et al. Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age. Neurology 2005; 65: 107-12. (Pubitemid 40967784)
13. Newson RS, Hek K, Luijendijk HJ, Hofman A, Witteman JC, Tiemeier H. Atherosclerosis and incident depression in late life.Arch Gen Psychiatry 2010; 67: 1144-51.
14. Brian EL. The concept of depression as a dysfunction of the immune system. Curr Immunol Rev 2010; 6: 205-12.
15. Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009; 65: 732-41.
16. Pace TW, Hu F, Miller AH. Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain Behav Immun 2007; 21: 9-19. (Pubitemid 44872932)
17. Gimeno D, Kivimäki M, Brunner EJ, et al. Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med 2009; 39: 413-23.
18. Bremmer MA, Beekman AT, Deeg DJ, et al. Inflammatory markers in late life depression: results from a population-based study. J Affect Disord 2008; 106: 249-55.
19. Capuron L, Su S, Miller AH, et al. Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry 2008; 64: 896-900.
20. Lespérance F, Frasure-Smith N, Théroux P, IrwinM. The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes. Am J Psychiatry 2004; 161: 271-77. (Pubitemid 38419278)
21. Skilton MR, Moulin P, Terra JL, Bonnet F. Associations between anxiety, depression, and the metabolic syndrome. Biol Psychiatry 2007; 62: 1251-7. (Pubitemid 350060887)