Cytotoxic effect of poly-dispersed single walled carbon nanotubes on erythrocytes in vitro and in vivo

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Sachar, Sumedha ^a   Saxena, Rajiv K ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; PHOSPHATIDYLSERINE; SINGLE WALLED NANOTUBE; ACID; CARBON NANOTUBE;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOTINYLATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ERYTHROCYTE; ERYTHROCYTE COUNT; ERYTHROCYTE LIFESPAN; ERYTHROCYTE MEMBRANE; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DAMAGE; MOUSE; NANOTOXICOLOGY; NONHUMAN; ANIMAL; BLOOD; C57BL MOUSE; CELL AGING; CELL CULTURE; CELL DEATH; CHEMICAL PHENOMENA; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENDOCYTOSIS; FLUORESCENCE; METABOLISM; PATHOLOGY;

ACIDS; ANEMIA; ANIMALS; CELL AGING; CELL DEATH; CELLS, CULTURED; ENDOCYTOSIS; ERYTHROCYTE COUNT; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FEMALE; FLUORESCENCE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NANOTUBES, CARBON; PHOSPHATIDYLSERINES;

EID: 79960439943     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022032     Document Type: Article

References (20)

1. Lam CW, James JT, McCluskey R, Hunter RL, (2004) Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77: 126-134.
2. Lam CW, James JT, McCluskey R, Arepalli S, Hunter RL, (2006) A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 36: 189-217.
3. Stoker E, Purser F, Kwon S, (2008) Alternative Estimation of Human Exposure of Single-Walled Carbon Nanotubes Using Three-Dimensional Tissue-Engineered Human Lung. Int J of Toxicol 27: 441-448.
4. Wang Y, Iqbal Z, Mitra S, (2006) Rapidly functionalized, water-dispersed carbon nanotubes at high concentration. J Am Chem Soc 128: 95-99.
5. Saxena RK, Williams W, McGee JK, Daniels MJ, Boykin E, et al. (2007) Enhanced in vitro and in vivo toxicity of poly-dispersed acid-functionalized singlewall carbon nanotubes. Nanotoxicology 1: 291-300.
6. Tong H, John MG, Saxena RK, (2009) Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice. Toxicol and Appl Pharmacol 239: 224-232.
7. Xu Z, Hu PA, (2008) Biological functionalization and fluorescent imaging of carbon nanotubes. Applied Surface Science 254: 1915-1918.
8. Mukherjee K, Chowdhury S, (2007) 9-O-Acetylated GD3 triggers programmed cell death in mature erythrocytes. Biochem and Biophy Res Commun 362: 651-657.
9. Khandelwal S, Saxena RK, (2006) Assessment of survival of aging erythrocyte in circulation and attendant changes in size and CD147 expression by a novel two step biotinylation method. Exp Gerontol 41: 855-861.
10. Khandelwal S, van Rooijen N, Saxena RK, (2007) Reduced expression of CD47 during murine red blood cell (RBC) senescence and its clearance from the circulation. Transfusion 47: 1725-732.
11. Khandelwal S, Saxena RK, (2008) A role of phosphatidylserine externalization in clearance of erythrocytes exposed to stress but not in eliminating aging population of erythrocyte in mice. Exp Gerontol 43: 764-770.
12. Saxena RK, Khandelwal S, (2009) Aging and destruction of blood erythrocytes in mice: A Hypothesis. Current Science. 97: 500-07.
13. Hawe A, Sutter M, Jiskoot W, (2008) Extrinsic Fluorescent Dyes as Tools for Protein Characterization. Pharma Research 25: 1487-1499.
14. Cardamone M, Puri NK, (1992) Spectrofluorimetric assessment of the surface hydrophobicity of proteins. Biochem J 282: 589-593.
15. Kiefer CR, Snyder LM, (2000) Oxidation and erythrocyte senescence. Curr Opin Hematol. 7: 113-6.
16. Erdely A, Hulderman T, Salmen R, Liston A, (2009) Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers. Nano Lett 9: 36-43.
17. Schipper ML, Nakayama-Ratchford N, Davis CR, Kam NW, Chu P, et al. (2008) A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. Nat Nanotechnol 3: 216-21.
18. Socolovsky M, (2007) Molecular insights into stress erythropoiesis. Curr Opin Hematol 14: 215-224.
19. Wu D-C, Paulson RF, (2010) Hypoxia Regulates BMP4 Expression in the Murine Spleen during the Recovery from Acute Anemia. PLoS ONE 5 (6): e11303.
20. McDevitt MR, Chattopadhyay D, Jaggi JS, Finn RD, Zanzonico PB, et al. (2007) PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice. Plos one 2 (9): e907.