메뉴 건너뛰기




Volumn 8, Issue 7, 2011, Pages 2017-2030

Imbalanced low-grade inflammation and endothelial activation in patients with type 2 diabetes mellitus and erectile dysfunction

Author keywords

Endothelial dysfunction; Erectile dysfunction; Inflammation; Type 2 diabetes mellitus

Indexed keywords

ANTIINFLAMMATORY AGENT; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

EID: 79960439511     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2011.02277.x     Document Type: Article
Times cited : (67)

References (61)
  • 1
    • 0036676711 scopus 로고    scopus 로고
    • Association of type and duration of diabetes with erectile dysfunction in a large cohort of men
    • Bacon CG, Hu F, Giovannucci E, Glasser D, Mittleman MA, Rimm EB. Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Diabetes Care 2002;25:1458-63.
    • (2002) Diabetes Care , vol.25 , pp. 1458-1463
    • Bacon, C.G.1    Hu, F.2    Giovannucci, E.3    Glasser, D.4    Mittleman, M.A.5    Rimm, E.B.6
  • 2
    • 10644227616 scopus 로고    scopus 로고
    • Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension, or both
    • Giuliano FA, Leriche A, Jaudinot EO, de Gendre AS. Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension, or both. Urology 2004;64:1196-201.
    • (2004) Urology , vol.64 , pp. 1196-1201
    • Giuliano, F.A.1    Leriche, A.2    Jaudinot, E.O.3    de Gendre, A.S.4
  • 3
    • 0033952259 scopus 로고    scopus 로고
    • Sexual function in men with diabetes type 2: Association with glycemic control
    • Romeo JH, Seftel AD, Madhun ZT, Aron DC. Sexual function in men with diabetes type 2: Association with glycemic control. J Urol 2000;163:788-91.
    • (2000) J Urol , vol.163 , pp. 788-791
    • Romeo, J.H.1    Seftel, A.D.2    Madhun, Z.T.3    Aron, D.C.4
  • 4
    • 0036980011 scopus 로고    scopus 로고
    • Etiology and treatment of erectile failure in diabetes mellitus
    • Richardson D, Vinik A. Etiology and treatment of erectile failure in diabetes mellitus. Curr Diab Rep 2002;2:501-9.
    • (2002) Curr Diab Rep , vol.2 , pp. 501-509
    • Richardson, D.1    Vinik, A.2
  • 5
    • 29544435525 scopus 로고    scopus 로고
    • Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: Common pathways and treatments?
    • Fonseca V, Jawa A. Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: Common pathways and treatments? Am J Cardiol 2005;96(S2):13-8.
    • (2005) Am J Cardiol , vol.96 , Issue.S2 , pp. 13-18
    • Fonseca, V.1    Jawa, A.2
  • 6
    • 0035116150 scopus 로고    scopus 로고
    • Diabetes and endothelial dysfunction: A clinical perspective
    • Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: A clinical perspective. Endocr Rev 2001;22:36-52.
    • (2001) Endocr Rev , vol.22 , pp. 36-52
    • Calles-Escandon, J.1    Cipolla, M.2
  • 7
    • 27744534428 scopus 로고    scopus 로고
    • Obesity, the metabolic syndrome, and sexual dysfunction
    • Esposito K, Giugliano D. Obesity, the metabolic syndrome, and sexual dysfunction. Int J Impot Res 2005;17:391-8.
    • (2005) Int J Impot Res , vol.17 , pp. 391-398
    • Esposito, K.1    Giugliano, D.2
  • 12
    • 17044458422 scopus 로고    scopus 로고
    • Glucose instability is associated with a high level of circulating P-selectin
    • Brun E, Zoppini G, Zamboni C, Bonora E, Muggeo M. Glucose instability is associated with a high level of circulating P-selectin. Diabetes Care 2001;24:1685.
    • (2001) Diabetes Care , vol.24 , pp. 1685
    • Brun, E.1    Zoppini, G.2    Zamboni, C.3    Bonora, E.4    Muggeo, M.5
  • 14
    • 34548398471 scopus 로고    scopus 로고
    • Is erectile dysfunction a low-grade systemic inflammatory condition?
    • Das UN. Is erectile dysfunction a low-grade systemic inflammatory condition? Eur Heart J 2007;28:642-3.
    • (2007) Eur Heart J , vol.28 , pp. 642-643
    • Das, U.N.1
  • 15
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF. Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 2003;2:812-7.
    • (2003) Diabetes , vol.2 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3    Hoffmann, K.4    Bergmann, M.M.5    Ristow, M.6    Boeing, H.7    Pfeiffer, A.F.8
  • 16
    • 33646460625 scopus 로고    scopus 로고
    • Endothelial dysfunction and low-grade inflammation explain much of the excess cardiovascular mortality in individuals with type 2 diabetes. The Hoorn Study
    • de Jager J, Dekker JM, Kooy A, Kostense PJ, Nijpels G, Heine RJ, Bouter LM, Stehouwer CDA. Endothelial dysfunction and low-grade inflammation explain much of the excess cardiovascular mortality in individuals with type 2 diabetes. The Hoorn Study. Arterioscler Thromb Vasc Biol 2006;26:1086-93.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1086-1093
    • de Jager, J.1    Dekker, J.M.2    Kooy, A.3    Kostense, P.J.4    Nijpels, G.5    Heine, R.J.6    Bouter, L.M.7    Stehouwer, C.D.A.8
  • 17
    • 12844266704 scopus 로고    scopus 로고
    • Chronic vascular inflammation in patients with type 2 diabetes: endothelial biopsy and RT-PCR analysis
    • Feng L, Matsumoto C, Schwartz A, Schmidt AM, Stern DM, Pile-Spellman J. Chronic vascular inflammation in patients with type 2 diabetes: endothelial biopsy and RT-PCR analysis. Diabetes Care 2005;8:379-84.
    • (2005) Diabetes Care , vol.8 , pp. 379-384
    • Feng, L.1    Matsumoto, C.2    Schwartz, A.3    Schmidt, A.M.4    Stern, D.M.5    Pile-Spellman, J.6
  • 18
    • 0031720795 scopus 로고    scopus 로고
    • Is type II diabetes mellitus a disease of the innate immune system?
    • Pickup J, Crook M. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998;41:1241-8.
    • (1998) Diabetologia , vol.41 , pp. 1241-1248
    • Pickup, J.1    Crook, M.2
  • 22
    • 0033969341 scopus 로고    scopus 로고
    • Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options
    • Gogos CA, Drosou E, Bassaris HP, Skoutelis A. Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options. J Infect Dis 2000;181:176-80.
    • (2000) J Infect Dis , vol.181 , pp. 176-180
    • Gogos, C.A.1    Drosou, E.2    Bassaris, H.P.3    Skoutelis, A.4
  • 23
    • 33745698667 scopus 로고    scopus 로고
    • Significance of changes in TNF- and IL-10 levels in the progression of heart failure subsequent to myocardial infarction
    • Kaur K, Sharma AK, Singal PK. Significance of changes in TNF- and IL-10 levels in the progression of heart failure subsequent to myocardial infarction. Am J Physiol Heart Circ Physiol 2006;291:H106-13.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Kaur, K.1    Sharma, A.K.2    Singal, P.K.3
  • 24
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults.
    • Expert Panel on the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-97.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 26
    • 77958192003 scopus 로고    scopus 로고
    • Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals
    • Joy NG, Hedrington MS, Briscoe VJ, Tate DB, Ertl AC, Davis SN. Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals. Diabetes Care 2010;33:1529-35.
    • (2010) Diabetes Care , vol.33 , pp. 1529-1535
    • Joy, N.G.1    Hedrington, M.S.2    Briscoe, V.J.3    Tate, D.B.4    Ertl, A.C.5    Davis, S.N.6
  • 27
    • 0025029664 scopus 로고
    • Characterization of two monoclonal antibodies directed against an adhesion molecule on human endothelial cells
    • Leeuwenberg JF, Jeunhomme GM, Buurman WA. Characterization of two monoclonal antibodies directed against an adhesion molecule on human endothelial cells. Transplant Proc 1990;22:1991-3.
    • (1990) Transplant Proc , vol.22 , pp. 1991-1993
    • Leeuwenberg, J.F.1    Jeunhomme, G.M.2    Buurman, W.A.3
  • 28
    • 0025015694 scopus 로고
    • IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro
    • Leeuwenberg JF, von Asmuth EJ, Jeunhomme TM, Buurman WA. IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro. J Immunol 1990;145:2110-4.
    • (1990) J Immunol , vol.145 , pp. 2110-2114
    • Leeuwenberg, J.F.1    von Asmuth, E.J.2    Jeunhomme, T.M.3    Buurman, W.A.4
  • 29
    • 0033373460 scopus 로고    scopus 로고
    • Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction
    • Rose RC, Cappelleri JC, Smith MD, Lipsky J, Peña JM. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999;11:319-26.
    • (1999) Int J Impot Res , vol.11 , pp. 319-326
    • Rose, R.C.1    Cappelleri, J.C.2    Smith, M.D.3    Lipsky, J.4    Peña, J.M.5
  • 31
    • 70349566992 scopus 로고    scopus 로고
    • Role of pro-/anti-inflammatory cytokines and their correlation with established risk factors in South Indians with coronary artery disease
    • Rajappa M, Sen SK, Sharma A. Role of pro-/anti-inflammatory cytokines and their correlation with established risk factors in South Indians with coronary artery disease. Angiology 2009;60:419-26.
    • (2009) Angiology , vol.60 , pp. 419-426
    • Rajappa, M.1    Sen, S.K.2    Sharma, A.3
  • 32
    • 69949093803 scopus 로고    scopus 로고
    • Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications
    • Goldberg RB. Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab 2009;94:3171-82.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3171-3182
    • Goldberg, R.B.1
  • 33
    • 1642372291 scopus 로고    scopus 로고
    • Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage
    • Bocchio M, Desideri G, Scarpelli P, Necozione S, Properzi G, Spartera C, Franc F. Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage. J Urol 2004;171:1601-4.
    • (2004) J Urol , vol.171 , pp. 1601-1604
    • Bocchio, M.1    Desideri, G.2    Scarpelli, P.3    Necozione, S.4    Properzi, G.5    Spartera, C.6    Franc, F.7
  • 35
    • 0141954218 scopus 로고    scopus 로고
    • Is type 2 diabetes mellitus a vascular condition?
    • Hu FB, Stampfer MJ. Is type 2 diabetes mellitus a vascular condition? Arterioscler Thromb Vasc Biol 2003;23:1715-6.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1715-1716
    • Hu, F.B.1    Stampfer, M.J.2
  • 38
    • 12144285424 scopus 로고    scopus 로고
    • Impact of diabetes mellitus on the severity of erectile dysfunction and response to treatment: Analysis of data from tadalafil clinical trials
    • Fonseca V, Seftel A, Denne J, Fredlund P. Impact of diabetes mellitus on the severity of erectile dysfunction and response to treatment: Analysis of data from tadalafil clinical trials. Diabetologia 2004;47:1914-23.
    • (2004) Diabetologia , vol.47 , pp. 1914-1923
    • Fonseca, V.1    Seftel, A.2    Denne, J.3    Fredlund, P.4
  • 39
    • 66749176147 scopus 로고    scopus 로고
    • Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy
    • Doupis J, Lyons TE, Wu S, Gnardellis C, Dinh T, Veves A. Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy. J Clin Endocrinol Metab 2009;94:2157-63.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 2157-2163
    • Doupis, J.1    Lyons, T.E.2    Wu, S.3    Gnardellis, C.4    Dinh, T.5    Veves, A.6
  • 40
    • 0036190082 scopus 로고    scopus 로고
    • Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or type II diabetes
    • Bluher M, Unger R, Rassoul F, Richter V, Paschke R. Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or type II diabetes. Diabetologia 2002;45:210-6.
    • (2002) Diabetologia , vol.45 , pp. 210-216
    • Bluher, M.1    Unger, R.2    Rassoul, F.3    Richter, V.4    Paschke, R.5
  • 43
    • 16344385996 scopus 로고    scopus 로고
    • Incidence of metabolic syndrome and insulin resistance in a population with organic erectile dysfunction
    • Bansal TC, Guay AT, Jacobson J, Woods BO, Nesto RW. Incidence of metabolic syndrome and insulin resistance in a population with organic erectile dysfunction. J Sex Med 2005;2:96-103.
    • (2005) J Sex Med , vol.2 , pp. 96-103
    • Bansal, T.C.1    Guay, A.T.2    Jacobson, J.3    Woods, B.O.4    Nesto, R.W.5
  • 44
    • 58149299559 scopus 로고    scopus 로고
    • The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction
    • Traish AM, Guay A, Feeley R, Saad F. The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction. J Androl 2009;30:10-22.
    • (2009) J Androl , vol.30 , pp. 10-22
    • Traish, A.M.1    Guay, A.2    Feeley, R.3    Saad, F.4
  • 46
    • 13944274907 scopus 로고    scopus 로고
    • Cytokines and vascular reactivity in resistance arteries
    • Vila E, Salaices M. Cytokines and vascular reactivity in resistance arteries. Am J Physiol Heart Circ Physiol 2005;288:H1016-21.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Vila, E.1    Salaices, M.2
  • 47
    • 33746234763 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome
    • Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, Zhang C. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 2006;99:69-77.
    • (2006) Circ Res , vol.99 , pp. 69-77
    • Picchi, A.1    Gao, X.2    Belmadani, S.3    Potter, B.J.4    Focardi, M.5    Chilian, W.M.6    Zhang, C.7
  • 49
    • 69849089255 scopus 로고    scopus 로고
    • TNF-alpha/IL-10 ratio and C-reactive protein as markers of the inflammatory response in CAD-prone North Indian patients with acute myocardial infarction
    • Goswami B, Rajappa M, Mallika V, Shukla DK, Kumar S. TNF-alpha/IL-10 ratio and C-reactive protein as markers of the inflammatory response in CAD-prone North Indian patients with acute myocardial infarction. Clin Chim Acta 2009;408:14-8.
    • (2009) Clin Chim Acta , vol.408 , pp. 14-18
    • Goswami, B.1    Rajappa, M.2    Mallika, V.3    Shukla, D.K.4    Kumar, S.5
  • 50
    • 33746395904 scopus 로고    scopus 로고
    • Relation between proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome
    • Kilic T, Ural D, Ural E, Yumuk Z, Agacdiken A, Sahin T, Kahraman G, Kozdag G, Vural A, Komsuoglu B. Relation between proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome. Heart 2006;92:1041-6.
    • (2006) Heart , vol.92 , pp. 1041-1046
    • Kilic, T.1    Ural, D.2    Ural, E.3    Yumuk, Z.4    Agacdiken, A.5    Sahin, T.6    Kahraman, G.7    Kozdag, G.8    Vural, A.9    Komsuoglu, B.10
  • 52
    • 0036260027 scopus 로고    scopus 로고
    • Interleukin-10 protects nitric oxide-dependent relaxation during diabetes. Role of superoxide
    • Gunnett CA, Heistad DD, Faraci FM. Interleukin-10 protects nitric oxide-dependent relaxation during diabetes. Role of superoxide. Diabetes 2002;51:1931-7.
    • (2002) Diabetes , vol.51 , pp. 1931-1937
    • Gunnett, C.A.1    Heistad, D.D.2    Faraci, F.M.3
  • 53
    • 0141621073 scopus 로고    scopus 로고
    • Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells
    • Cattaruzza M, Slodowski W, Stojakovic M, Krzesz R, Hecker M. Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells. J Biol Chem 2003;278:37874-80.
    • (2003) J Biol Chem , vol.278 , pp. 37874-37880
    • Cattaruzza, M.1    Slodowski, W.2    Stojakovic, M.3    Krzesz, R.4    Hecker, M.5
  • 54
    • 0029786764 scopus 로고    scopus 로고
    • Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells
    • Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci U S A 1996;93:9114-8.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9114-9118
    • Khan, B.V.1    Harrison, D.G.2    Olbrych, M.T.3    Alexander, R.W.4    Medford, R.M.5
  • 55
    • 3242745916 scopus 로고    scopus 로고
    • Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease
    • Fichtlscherer S, Breuer S, Heeschen C, Dimmeler S, Zeiher AM. Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease. J Am Coll Cardiol 2004;44:44-9.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 44-49
    • Fichtlscherer, S.1    Breuer, S.2    Heeschen, C.3    Dimmeler, S.4    Zeiher, A.M.5
  • 57
    • 0037631831 scopus 로고    scopus 로고
    • Insulin resistance and chronic cardiovascular inflammatory syndrome
    • Fernández-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 2003;24:278-301.
    • (2003) Endocr Rev , vol.24 , pp. 278-301
    • Fernández-Real, J.M.1    Ricart, W.2
  • 60
  • 61
    • 0036224269 scopus 로고    scopus 로고
    • Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes. The Leiden 85-Plus Study
    • van Exel E, Gussekloo J, de Craen AJM, Frolich M, van der Wiel AB, Westendorp RGJ. Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes. The Leiden 85-Plus Study. Diabetes 2002;51:1088-92.
    • (2002) Diabetes , vol.51 , pp. 1088-1092
    • van Exel, E.1    Gussekloo, J.2    de Craen, A.J.M.3    Frolich, M.4    van der Wiel, A.B.5    Westendorp, R.G.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.