Intraocular expression of thymosin β4 in proliferative diabetic retinopathy

Acta Ophthalmologica

Volumn 89, Issue 5, 2011, Pages

  Wang, Jia Yan ^a   Lu, Qiang ^a   Tao, Yong ^a,b   Jiang, Yan Rong ^a   Jonas, Jost B ^b  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

diabetes mellitus; diabetic retinopathy; neovascularization; thymosin 4

Indexed keywords

CD31 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; THYMOSIN BETA4; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NERVE MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RETINA NEOVASCULARIZATION; RNA ANALYSIS; STREPTOZOCIN DIABETES;

ADULT; AGED; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MALE; MIDDLE AGED; RATS; RATS, SPRAGUE-DAWLEY; RETINAL NEOVASCULARIZATION; THYMOSIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VITREOUS BODY;

EID: 79960422318     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/j.1755-3768.2011.02114.x     Document Type: Article

References (35)

1. Aiello LP, Avery RL, Arrigg PG, et al., (1994): Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331: 1480-1487. (Pubitemid 24356306)
2. Barber AJ, Antonetti DA, &, Gardner TW, (2000): Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. Invest Ophthalmol Vis Sci 41: 3561-3568.
3. Barouch FC, &, Miller JW, (2006): Potential future targets for treating ocular neovascularization. Ophthalmol Clin North Am 19: 401-409. (Pubitemid 44279355)
4. Cha HJ, Jeong MJ, &, Kleinman HK, (2003): Role of TB4 in tumor metastasis and angiogenesis. J Natl Cancer Inst 95: 1674-1680.
5. Congdon NG, Friedman DS, &, Lietman T, (2003): Important causes of visual impairment in the world today. JAMA 290: 2057-2060. (Pubitemid 37430590)
6. Frohm M, Gunne H, Bergman AC, et al., (1996): Biochemical and antibacterial analysis of human wound and blister fluid. Eur J Biochem 237: 86-92. (Pubitemid 26110276)
7. Funatsu H, Yamashita H, Nakamura S, Mimura T, Eguchi S, Noma H, &, Hori S, (2006): Vitreous levels of pigment epithelium derived factor and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology 113: 294-301. (Pubitemid 43170779)
8. Goldstein AL, Slater FD, &, White A, (1966): Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin). Proc Natl Acad Sci 56: 1010-1017.
9. Goldstein AL, Hannappel E, &, Kleinman HK, (2005): TB4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med 11: 421-429. (Pubitemid 41254045)
10. Gõmez-Márquez J, Franco del Amo F, Carpintero P, &, Anadõn R, (1996): High levels of mouse thymosin beta 4 mRNA in differentiating P19 embryonic cells and during development of cardiovascular tissues. Biochim Biophys Acta 1306: 187-193. (Pubitemid 26155067)
11. Grant DS, Kinsella JL, Kibbey MC, LaFlamme S, Burbelo PD, Goldstein AL, &, Kleinman HK, (1995): Matrigel induces TB4 gene in differentiating endothelial cells. J Cell Sci 108: 3685-3694. (Pubitemid 26003202)
12. Grant DS, Rose W, Yaen C, Goldstein A, Martinez J, &, Kleinman H, (1999): TB4 enhances endothelial cell differentiation and angiogenesis. Angiogenesis 3: 125-135. (Pubitemid 129644639)
13. Guidry C, King JL, &, Mason JO 3rd, (2009): Fibrocontractive Müller cell phenotypes in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 50: 1929-1939.
14. Huff T, Muller CS, Otto AM, Netzker R, &, Hannappel E, (2001): Beta thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol 33: 205-220. (Pubitemid 32304390)
15. Ikeda T, Homma Y, Nisida K, Hirase K, Sotozono C, Kinoshita S, &, Puro DG, (1998): Expression of transforming growth factor-beta s and their receptors by human retinal glial cells. Curr Eye Res 17: 546-550. (Pubitemid 28306511)
16. Jonas JB, &, Neumaier M, (2007a): Concentrations of vascular endothelial growth factor and basic fibroblast factor in exudative age-related macular degeneration, diffuse diabetic macular edema, and normals. Ophthalmic Res 39: 139-142. (Pubitemid 46975978)
17. Jonas JB, &, Neumaier M, (2007b): Erythropoietin levels in aqueous humour in eyes with exudative age-related macular degeneration and diabetic retinopathy. Clin Experiment Ophthalmol 35: 186-187. (Pubitemid 46390811)
18. Katsura Y, Okano T, Matsuno K, et al., (2005): Erythropoietin is highly elevated in vitreous fluid of patients with proliferative diabetic retinopathy. Diabetes Care 28: 2252-2254. (Pubitemid 41242480)
19. Li X, Zheng L, Peng F, Qi C, Zhang X, Zhou A, Liu Z, &, Wu S, (2007): Recombinant thymosin beta 4 can promote full-thickness cutaneous wound healing. Protein Expr Purif 56: 229-236. (Pubitemid 350011045)
20. Malinda K, Goldstein A, &, Kleinman H, (1997): TB4 stimulates directional migration of human umbilical vein endothelial cells. J FASEB 11: 474-481. (Pubitemid 27259989)
21. Marx J, (2007): Biomedicine. Thymosins: clinical promise after a decades-long search. Science 316: 682-683. (Pubitemid 46717651)
22. McDonnell PJ, Fine SL, &, Hillis AI, (1982): Clinical features of idiopathic macular cysts and holes. Am J Ophthalmol 93: 777-786. (Pubitemid 12120320)
23. Philp D, Goldstein AL, &, Kleinman HK, (2004): TB4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev 125: 113-115. (Pubitemid 38177569)
24. Rungger-Brändle E, Dosso AA, &, Leuenberger PM, (2000): Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci 41: 1971-1980. (Pubitemid 30354375)
25. Safer D, Elzinga M, &, Nachmias VT, (1991): Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. J Biol Chem 266: 4029-4032. (Pubitemid 21909312)
26. Simõ R, Carrasco E, García-Ramírez M, &, Hernández C, (2006): Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy. Curr Diabetes Rev 2: 71-98. (Pubitemid 44082952)
27. Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, &, Riley PR, (2007): Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature 445: 177-182. (Pubitemid 46095717)
28. Sosne G, Chan CC, Thai K, Kennedy M, Szliter EA, Hazlett LD, &, Kleinman HK, (2001): Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp Eye Res 72: 605-608. (Pubitemid 32977230)
29. Sosne G, Siddiqi A, &, Kurpakus-Wheater M, (2004): Thymosin-beta4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro. Invest Ophthalmol Vis Sci 45: 1095-1100. (Pubitemid 38869013)
30. Sosne G, Qiu P, Kurpakus-Wheater M, &, Matthew H, (2010): Thymosin beta4 and corneal wound healing: visions of the future. Ann N Y Acad Sci 1194: 190-198.
31. Sun HQ, Kwiatkowska K, &, Yin HL, (1996): β-Thymosins are not simple actin monomer buffering proteins: insights from overexpression studies. J Biol Chem 271: 9223-9230.
32. Tao Y, Lu Q, Jiang YR, Qian J, Wang JY, Gao L, &, Jonas JB, (2010): Apelin in plasma and vitreous and in fibrovascular retinal membranes from patients with proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 51: 4237-4242.
33. Tielsch JM, Sommer A, Witt K, Katz J, &, Royall RM, (1990): Blindness and visual impairment in an American urban population. The Baltimore Eye Survey. Arch Ophthalmol 108: 286-290. (Pubitemid 20058168)
34. Watanabe D, Suzuma K, Matsui S, et al., (2005): Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med 353: 782-792. (Pubitemid 41215487)
35. Wilkinson CP, Ferris FL 3rd, Klein RE, et al., (2003): Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110: 1677-1682. (Pubitemid 37025422)