Glutamate does not play a major role in controlling bone growth

Journal of Bone and Mineral Research

Volumn 16, Issue 4, 2001, Pages 742-749

  Gray, Colin ^a   Marie, Hélène ^a   Arora, Maureen ^a   Tanaka, Kohichi ^b   Boyde, Alan ^a   Jones, Sheila ^a   Attwell, David ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Bone; GLAST; Glutamate; Knockout; Transporter

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; DIZOCILPINE; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; GROWTH STIMULATION; NEWBORN; NONHUMAN; OSTEOLYSIS; RAT; RECEPTOR UPREGULATION; TRABECULAR BONE;

2-AMINO-5-PHOSPHONOVALERATE; ALVEOLAR BONE LOSS; AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ANIMALS, NEWBORN; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BONE DISEASES, METABOLIC; BONE REMODELING; BONE RESORPTION; CELLS, CULTURED; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMUR; GLUTAMIC ACID; GLYCINE; HUMERUS; MANDIBLE; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; N-METHYLASPARTATE; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0035076416     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.4.742     Document Type: Article

References (12)

1. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
2. Physiological and pathological operation of glutamate transporters
3. Mechanically regulated expression of a neural glutamate transporter in bone: A role for excitatory amino acids as osteotropic agents?
4. Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells
5. Glutamate receptors are expressed by bone cells and are involved in bone resorption
6. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
7. The isolation, culture and functional assay of osteoclasts and osteoblasts
8. Characterisation of glutamate transporter variants
9. Constitutive glutamate signalling is necessary for bone formation in vitro and activates the transcription factor, AP1
10. Mice lacking tartrate resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
11. The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation
12. Focal glutamate signalling in osteoblasts by regulated vesicular exocytosis