Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence

Rejuvenation Research

Volumn 14, Issue 3, 2011, Pages 241-248

  Talaber, Gergely ^a   Kvell, Krisztian ^a   Varecza, Zoltan ^a   Boldizsar, Ferenc ^a   Parnell, Sonia M ^b   Jenkinson, Eric J ^b   Anderson, Graham ^b   Berki, Timea ^a   Pongracz, Judit E ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; MOLECULAR MARKER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXN1; UNCLASSIFIED DRUG; WNT4 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL AGING; CELL DEATH; CELL PROTECTION; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG MEGADOSE; EPITHELIUM CELL; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; T LYMPHOCYTE;

ADIPOSE TISSUE; ANIMALS; CELL AGING; CELL LINE; CELL TRANSDIFFERENTIATION; CYTOPROTECTION; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; MICE; MICE, INBRED BALB C; RECEPTORS, GLUCOCORTICOID; THYMUS GLAND; WNT4 PROTEIN;

EID: 79960381022     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2010.1110     Document Type: Article

References (40)

1. Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev 2003;2:119-125. (Pubitemid 37443848)
2. Rodriguez-Abreu D, Bordoni A, Zucca E. Epidemiology of hematological malignancies. Ann Oncol 2007;18(Suppl 1):i3-i8. (Pubitemid 46344633)
3. Rhen T, Cidlowski JA. Antiinflammatory action of gluco-corticoids\new mechanisms for old drugs. N Engl J Med 2005;353:1711-1723.
4. Greenstein S, Ghias K, Krett NL, Rosen ST. Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies. Clin Cancer Res 2002;8:1681-1694. (Pubitemid 34633722)
5. Schmidt S, Rainer J, Ploner C, Presul E, Rimil S, Kofler R. Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. Cell Death Differ 2004;11(Suppl 1):S45-S55. (Pubitemid 39136798)
6. Stahn C, Lowenberg M, Hommes DW, Buttgereit F. Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists. Mol Cell Endocrinol 2007; 275:71-78. (Pubitemid 47259281)
7. Wust S, van den Brandt J, Tischner D, Kleiman A, Tuck-ermann JP, Gold R, Luhder F, Reichardt HM. Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J Immunol 2008; 180:8434-8443.
8. Wiegers GJ, Knoflach M, Bock G, Niederegger H, Dietrich H, Falus A, Boyd R, Wick G. CD4(\+)CD8(\+)TCR(low) thymo-cytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis. Eur J Immunol 2001;31:2293-2301. (Pubitemid 32785347)
9. Berki T, Palinkas L, Boldizsar F, Nemeth P. Glucocorticoid (GC) sensitivity and GC receptor expression differ in thy-mocyte subpopulations. Int Immunol 2002;14:463-469. (Pubitemid 34521068)
10. Palinkas L, Talaber G, Boldizsar F, Bartis D, Nemeth P, Berki T. Developmental shift in TcR-mediated rescue of thymo-cytes from glucocorticoid-induced apoptosis. Immunobiology 2008;213:39-50.
11. Boldizsar F, Palinkas L, Czompoly T, Bartis D, Nemeth P, Berki T. Low glucocorticoid receptor (GR), high Dig2 and low Bcl-2 expression in double positive thymocytes of BALB/c mice indicates their endogenous glucocorticoid hormone exposure. Immunobiology 2006;211:785-796. (Pubitemid 44734621)
12. Jondal M, Pazirandeh A, Okret S. Different roles for gluco-corticoids in thymocyte homeostasis? Trends Immunol 2004; 25:595-600. (Pubitemid 39369736)
13. Blomgren H, Andersson B. Characteristics of the immuno-competent cells in the mouse thymus: cell population changes during cortisone-induced atrophy and subsequent regeneration. Cell Immunol 1970;1:545-560.
14. Boersma W, Betel I, van der Westen G. Thymic regeneration after dexamethasone treatment as a model for subpopula-tion development. Eur J Immunol 1979;9:45-52. (Pubitemid 9201725)
15. Dardenne M, Itoh T, Homo-Delarche F. Presence of gluco-corticoid receptors in cultured thymic epithelial cells. Cell Immunol 1986;100:112-118. (Pubitemid 16122361)
16. Fletcher AL, Lowen TE, Sakkal S Reiseger JJ, Hammett MV, Seach N, Scott HS, Boyd RL, Chidgey AP. Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexa-methasone treatment. J Immunol 2009;183:823-831.
17. Taub DD, Longo DL. Insights into thymic aging and regeneration. Immunol Rev 2005;205:72-93. (Pubitemid 40780178)
18. Qiao S, Chen L, Okret S, Jondal M. Age-related synthesis of glucocorticoids in thymocytes. Exp Cell Res 2008;314: 3027-3035.
19. Dixit VD. Thymic fatness and approaches to enhance thymopoietic fitness in aging. Curr Opin Immunol 2010;22: 521-528.
20. Kvell K, Varecza Z, Bartis D, Hesse S, Parnell S, Anderson G, Jenkinson EJ, Pongracz JE. Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence. PLoS One 2010;5: e10701.
21. Balciunaite G, Keller MP, Balciunaite E, Piali L, Zuklys S, Mathieu YD, Gill J, Boyd R, Sussman DJ, Hollander GA. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol 2002;3:1102-1108. (Pubitemid 35363665)
22. Pongracz J, Hare K, Harman B, Anderson G, Jenkinson EJ. Thymic epithelial cells provide WNT signals to developing thymocytes. Eur J Immunol 2003;33:1949-1956. (Pubitemid 37120867)
23. Buttgereit F, Straub RH, Wehling M, Burmester GR. Gluco-corticoids in the treatment of rheumatic diseases: an update on the mechanisms of action. Arthritis Rheum 2004;50:3408-3417. (Pubitemid 39488664)
24. Buttgereit F, da Silva JA, Boers M, Burmester G-R, Cutolo M, Jacobs J, Kirwan J, Kohler L, van Riel P, Vischer T, Bijisma JWJ. Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology. Ann Rheum Dis 2002;61:718-722. (Pubitemid 34787710)
25. Berki T, Kumanovics G, Kumanovics A, Falus A, Ujhelyi E, Nemeth P. Production and flow cytometric application of a monoclonal anti-glucocorticoid receptor antibody. J Immunol Methods 1998;214:19-27. (Pubitemid 28335535)
26. Revollo JR, Cidlowski JA. Mechanisms generating diversity in glucocorticoid receptor signaling. Ann NY Acad Sci 2009; 1179:167-178.
27. Bayo P, Sanchis A, Bravo A, Cascallana JL, Buder K, Tuck-ermann J, Schutz G, Perez P. Glucocorticoid receptor is required for skin barrier competence. Endocrinology 2008; 149:1377-1388. (Pubitemid 351397923)
28. Manwani N, Gagnon S, Post M, Joza S, Muglia L, Cornejo S, Kaplan F, Sweezey NB. Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor. Am J Respir Cell Mol Biol 2010;43:503-606.
29. Gray DH, Chidgey AP, Boyd RL. Analysis of thymic stromal cell populations using flow cytometry. J Immunol Methods 2002;260:15-28. (Pubitemid 34132869)
30. Rodewald HR. Thymus organogenesis. Annu Rev Immunol 2008;26:355-388.
31. Alves NL, Huntington ND, Rodewald HR, Di Santo JP. Thymic epithelial cells: the multi-tasking framework of the T cell "cradle." Trends Immunol 2009;30:468-474.
32. Sacedon R, Vicente A, Varas A, Jimenez E, Munoz JJ, Zapata AG. Glucocorticoid-mediated regulation of thymic dendritic cell function. Int Immunol 1999;11:1217-1224.
33. Pan J, Ju D, Wang Q, Zhang M, Xia D, Zhang L, Cao X. Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway. Immunol Lett 2001;76: 153-161. (Pubitemid 32295935)
34. Youm YH, Yang H, Sun Y, Smith RG, Manley NR, Van-danmagsar B, Dixit VD. Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenviron-ment by accelerating thymic adiposity. J Biol Chem 2009; 284:7068-7077.
35. Youm YH, Yang H, Amin R, Smith SR, Leff T, Dixit VD. Thiazolidinedione treatment and constitutive-PPARgamma activation induces ectopic adipogenesis and promotes age-related thymic involution. Aging Cell 2010;9:478-489.
36. Chen L, Xiao S, Manley NR. Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner. Blood 2009;113:567-574.
37. Cheng L, Guo J, Sun L, Fu J, Barnes PF, Metzger D, Chambon P, Oshima RG, Amagai T, Su D-M. Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. J Biol Chem 2010;285:5836-5847.
38. Elenkov IJ. Glucocorticoids and the Th1/Th2 balance. Ann NY Acad Sci 2004;1024:138-146. (Pubitemid 38879598)
39. Bassett D, Hirata F, Gao X, Kannan R, Kerr J, Doyon-Reale N, Wilson S, Lieh-Lai M. Reversal of methylprednisolone effects in allergen-exposed female BALB/c mice. J Toxicol Environ Health A 2010;73:711-724.
40. Royer B, Lee K, Gruson B, Roszkiewicz F, Al Khedr A, Colson A, Camboulives A, Bierling P, Marolleau JP. Methylprednisolone-induced immune thrombocytopenia. Blood 2010;115:5431-5432.