Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7- chloroquinolines (n = 3′ or 4′) against Plasmodium falciparum in in vitro models

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 15, 2011, Pages 4512-4515

  Gordey, Erin E ^a   Yadav, Paras N ^a   Merrin, Marcus P ^b   Davies, Jill ^c   Ward, Steven A ^c   Woodman, Grant M J ^a   Sadowy, Amber L ^a   Smith, Todd G ^a   Gossage, Robert A ^a,d  

^a ACADIA UNIVERSITY   (Canada)

^b AMERICAN UNIVERSITY OF ANTIGUA   (Antigua and Barbuda)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d RYERSON UNIVERSITY   (Canada)

Author keywords

Anti malarial; IC 50; Oxazoline; Plasmodium falciparum; Pre clinical evaluation; Toxicity

Indexed keywords

4 N [ANILINYL N (OXAZOLYL)] 7 CHLOROQUINOLINE; ANTIMALARIAL AGENT; ATOVAQUONE; CHLOROQUINE; OXAZOLE DERIVATIVE; PALLADIUM; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL MODIFICATION; CROSS COUPLING REACTION; CYTOTOXICITY; DRUG SYNTHESIS; HYBRID; IN VITRO STUDY; MONONUCLEAR CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASMODIUM FALCIPARUM;

ANTIMALARIALS; CHLOROQUINE; MODELS, BIOLOGICAL; OXAZOLES; PLASMODIUM FALCIPARUM; QUINOLINES;

PLASMODIUM FALCIPARUM;

EID: 79960380096     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.131     Document Type: Article

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