Enantiomeric separation of (R, S)-naproxen by recycling high speed counter-current chromatography with hydroxypropyl-β-cyclodextrin as chiral selector

Journal of Chromatography A

Volumn 1218, Issue 32, 2011, Pages 5434-5440

  Tong, Shengqiang ^a,b   Guan, Yi Xin ^a   Yan, Jizhong ^b   Zheng, Bei ^b   Zhao, Liying ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

(R, S) Naproxen; Chiral separation; Hydroxypropyl cyclodextrin; Recycling high speed counter current chromatography

Indexed keywords

AQUEOUS PHASE; CHIRAL SELECTOR; CHIRAL SEPARATIONS; ENANTIOMERIC EXCESS; ENANTIOMERIC SEPARATION; ENANTIOSEPARATIONS; EQUILIBRIUM TEMPERATURES; HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY; INFLUENCE FACTORS; MOLAR RATIO; NAPROXENS; PHOSPHATE BUFFER SOLUTIONS; SEPARATION CONDITION; TECHNICAL DETAILS; TWO-PHASE SOLVENT SYSTEM;

CHIRALITY; ENANTIOMERS; HEXANE; ORGANIC SOLVENTS; RECYCLING;

CHROMATOGRAPHY;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 4 METHYL 2 PENTANONE; ACETIC ACID ETHYL ESTER; HEXANE; METHANOL; NAPROXEN; PHOSPHATE; TERT BUTYL METHYL ETHER;

AQUEOUS SOLUTION; ARTICLE; CHIRALITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PURITY; ELUTION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PH; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RACEMIC MIXTURE; RECYCLING HIGH SPEED COUNTER CURRENT CHROMATOGRAPHY; TEMPERATURE;

ABSORPTION; BETA-CYCLODEXTRINS; COUNTERCURRENT DISTRIBUTION; NAPROXEN; STEREOISOMERISM;

EID: 79960369893     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.06.015     Document Type: Article

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