Enantiomeric separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs by HPLC with hydroxypropyl-β-cyclodextrin as chiral mobile phase additive

Biomedical Chromatography

Volumn 24, Issue 8, 2010, Pages 799-807

  Ye, Jincui ^a,b   Yu, Wenying ^b   Chen, Guosheng ^b   Shen, Zhengrong ^b   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

2 arylpropionic acids; Enantiomeric separation; HPLC; Hydroxypropyl cyclodextrin

Indexed keywords

DRUG PRODUCTS; ENANTIOMERS; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

2-ARYLPROPIONIC ACID; ARYLPROPIONIC ACIDS; CHIRAL MOBILE PHASE ADDITIVE; ENANTIOMERIC SEPARATION; ENANTIOSEPARATIONS; HPLC; HYDROXYPROPYL-Β- CYCLODEXTRIN; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NONSTEROIDAL ANTI-INFLAMMATORY DRUGS; SKIN PERMEATION;

CYCLODEXTRINS;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CARPROFEN; FENOPROFEN; FLURBIPROFEN; IBUPROFEN; INDOPROFEN; KETOPROFEN; METHANOL; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROPIONIC ACID DERIVATIVE; SODIUM DIHYDROGEN PHOSPHATE; SUPROFEN; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; PROPIONIC ACID;

ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IONIC STRENGTH; NONHUMAN; PH; RABBIT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SKIN PERMEABILITY; TEMPERATURE; CHEMISTRY; DEVICES; EVALUATION STUDY; ISOLATION AND PURIFICATION; PROCEDURES; STEREOISOMERISM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BETA-CYCLODEXTRINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PROPIONATES; STEREOISOMERISM;

EID: 77954746016     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1365     Document Type: Article

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