Separation of α-cyclohexylmandelic acid enantiomers using biphasic chiral recognition high-speed counter-current chromatography

Journal of Chromatography A

Volumn 1217, Issue 18, 2010, Pages 3044-3052

  Tong, Shengqiang ^a,b   Yan, Jizhong ^b   Guan, Yi Xin ^a   Fu, Yaner ^b,c   Ito, Yoichiro ^d  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c Zhejiang Huahai Pharmaceutical Co Ltd   (China)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Cyclohexylmandelic acid; Biphasic chiral recognition; Chiral separation; High speed counter current chromatography; Optical activity

Indexed keywords

BIPHASIC; CHIRAL RECOGNITION; CHIRAL SEPARATIONS; HIGH-SPEED COUNTER CURRENT CHROMATOGRAPHY; OPTICAL ACTIVITY;

CHROMATOGRAPHY; CODES (SYMBOLS); ENANTIOMERS; ETHERS; HEXANE; HYDROPHILICITY; OPTICAL MATERIALS; ORGANIC SOLVENTS; PHASE SEPARATION; SPEED;

CHIRALITY;

2 ETHYLHEXYL TARTRATE; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALPHA CYCLOHEXYLMANDELIC ACID; HEXANE; MANDELIC ACID DERIVATIVE; TARTARIC ACID DERIVATIVE; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG; WATER;

AQUEOUS SOLUTION; ARTICLE; CHIRAL CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; ISOTHERM; LIPOPHILICITY; PARTITION COEFFICIENT; PH MEASUREMENT; PHASE SEPARATION; PRIORITY JOURNAL; RACEMIC MIXTURE; TEMPERATURE MEASUREMENT;

BETA-CYCLODEXTRINS; CHROMATOGRAPHY, LIQUID; COUNTERCURRENT DISTRIBUTION; MACROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 77951203857     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.02.077     Document Type: Article

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