Exploring QSARs for 5-Lipoxygenase (5-LO) Inhibitory Activity of 2-Substituted 5-Hydroxyindole-3-Carboxylates by CoMFA and CoMSIA

Chemical Biology and Drug Design

Volumn 78, Issue 2, 2011, Pages 314-321

  Zheng, Junxia ^a   Xiao, Gaokeng ^b   Guo, Jialiang ^b   Zheng, Yang ^a   Gao, Hao ^b   Zhao, Suqing ^a   Zhang, Kun ^a   Sun, Pinghua ^b  

^a GUANGDONG UNIVERSITY OF TECHNOLOGY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

5 lipoxygenase inhibitors; CoMFA; CoMSIA; Indole; QSAR

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE;

ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; HUMAN; HUMAN CELL; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

ARACHIDONATE 5-LIPOXYGENASE; CARBOXYLIC ACIDS; DRUG DESIGN; ENZYME ACTIVATION; INDOLES; LIPOXYGENASE INHIBITORS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960368550     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01146.x     Document Type: Article

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