Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: An example from the pineal gland

Journal of Neurochemistry

Volumn 75, Issue 5, 2000, Pages 2123-2132

  Schomerus, C ^a   Korf, H W ^a   Laedtke, E ^a   Weller, J L ^a   Klein, D C ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Arylalkylamine N acetyltransferase; Biological rhythms; Neural signaling; Noradrenaline; Pineal gland; Proteasomal proteolysis

Indexed keywords

ARALKYLAMINE ACETYLTRANSFERASE; CYCLIC AMP; MELATONIN; MESSENGER RNA; NORADRENALIN; PROTEASOME;

ADRENERGIC STIMULATION; ANIMAL CELL; ARTICLE; BIOLOGICAL RHYTHM; CATTLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME REGULATION; ENZYME SYNTHESIS; HORMONE SYNTHESIS; IMMUNOHISTOCHEMISTRY; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PINEAL BODY; PINEALOCYTE; PRIORITY JOURNAL; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANIMAL; ARYLAMINE N-ACETYLTRANSFERASE; BUCLADESINE; CATTLE; CELLS, CULTURED; CYCLIC AMP; CYSTEINE ENDOPEPTIDASES; FEMALE; FORSKOLIN; MALE; MULTIENZYME COMPLEXES; NEURONS; NOREPINEPHRINE; PEPTIDE HYDROLASES; PINEAL GLAND; PROTEASE INHIBITORS; PROTEIN SYNTHESIS INHIBITORS; PUROMYCIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; STIMULATION, CHEMICAL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033792485     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752123.x     Document Type: Article

References (46)

1. Ubiquitin, cellular inclusions and their role in neurodegeneration
2. The rat arylalkylamine N-acetyltransferase gene promoter
3. Avian melatonin synthesis: Photic and circadian regulation of serotonin N-acetyltransferase mRNA in the chicken pineal gland and retina
4. Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture
5. Diurnal variation in mRNA encoding serotonin N-acetyltransferase in the pineal gland
6. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
7. Serotonin N-acetyltransferase promoter: Conditional pineal/retinal gene expression in the transgenic rat
8. Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis
9. Multiple receptor regulation of cyclic nucleotides in rat pinealocytes
10. Deubiquitinating enzymes: Their diversity and emerging roles
11. Pineal serotonin N-acetyltransferase: Expression cloning and molecular analysis
12. Bovine arylalkylamine N-acetyltransferase activity correlated with mRNA expression in pineal and retina
13. Deubiquitinating enzymes: A new class of biological regulators
14. Norepinephrine release in the rat pineal gland: The input from the biological clock measured by in vivo microdialysis
15. Lactacystin, proteasome function, and cell fate
16. Ovine arylalkylamine N-acetyltransferase in the pineal and pituitary glands: Differences in function and regulation
17. Melatonin production: Proteasomal proteolysis in serotonin N-acetyltransferase regulation
18. Melatonin: Daily cycle in plasma and cerebrospinal fluid of calves
19. Roles of ubiquitin-mediated proteolysis in cell cycle control
20. The ubiquitin system
21. A potent inhibitor of the melatonin rhythm enzyme
22. Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: Control by the retinohypothalamic tract and the suprachiasmatic nucleus
23. The melatonin rhythm-generating enzyme: Molecular regulation of serotonin N-acetyltransferase in the pineal gland
24. Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species
25. The pineal organ, its hormone melatonin, and the photoneuroendocrine system
26. Transcription factors in neuroendocrine regulation: Rhythmic changes in pCREB and ICER levels frame melatonin synthesis
27. PKA type II regulation of CREB phosphorylation and melatonin synthesis in the rat pineal gland
28. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
29. Rapid nocturnal increase in ovine pineal N-acetyltransferase activity and melatonin synthesis: Effects of cycloheximide
30. Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons
31. The major substrates for TAP in vivo are derived from newly synthesized proteins
32. A diurnal melatonin rhythm in primate cerebrospinal fluid
33. Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: Involvement of a β-adrenergic/cyclic AMP mechanism
34. Melatonin synthesis: Analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland
35. Bovine pinealocytes in monolayer culture: Studies on the adrenergic regulation of melatonin secretion
36. 2+](i) analysis and biochemical characterization of pinealocytes immobilized with novel attachment peptide preparation
37. Analyses of signal transduction cascades in rat pinealocytes reveal a switch in cholinergic signaling during postnatal development
38. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
39. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
40. Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland
41. Norepinephrine-induced phosphorylation of the transcription factor CREB in isolated rat pinealocytes: An immunocytochemical study
42. A semiquantitative image-analytical method for the recording of dose-response curves in immunocytochemical preparations
43. Ubiquitin-like proteins: New wines in new bottles
44. Chicken pineal melatonin synthesis: Light and cyclic AMP control abundance of serotonin N-acetyltransferase protein