Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats

Behavioural Brain Research

Volumn 225, Issue 1, 2011, Pages 15-22

  Calzavara, Mariana Bendlin ^a   Levin, Raquel ^a   Medrano, Wladimir Agostini ^a   Almeida, Valéria ^a   Sampaio, Antônio Pereira Fróis ^a   Barone, Lucas Cerqueira ^a   Frussa Filho, Roberto ^a   Abílio, Vanessa Costhek ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

ADHD; Amphetamine; Antipsychotics; Hyperlocomotion; Schizophrenia; SHR; Social interaction

Indexed keywords

AMPHETAMINE; CLOZAPINE; HALOPERIDOL; QUETIAPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DRUG EFFECT; LOCOMOTION; MALE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; REARING; SOCIAL BEHAVIOR; SOCIAL ENVIRONMENT; SOCIAL INTERACTION; SPONTANEOUSLY HYPERTENSIVE RAT; STRAIN DIFFERENCE; WISTAR RAT;

AMPHETAMINE; ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM STIMULANTS; DRUG INTERACTIONS; EXPLORATORY BEHAVIOR; MALE; MOTOR ACTIVITY; RATS; RATS, INBRED SHR; SOCIAL BEHAVIOR;

EID: 79960321395     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.06.026     Document Type: Article

References (89)

1. Marsh P.J., Williams L.M. ADHD and schizophrenia phenomenology: visual scan paths to emotional faces as a potential psychophysiological marker?. Neurosci Biobehav Rev 2006, 30(5):651-665.
2. Goldstein G. Neurobehavioral heterogeneity in schizophrenia. Arch Clin Neuropsychol 1994, 9(3):265-276.
3. Biederman J., Faraone S.V. Current concepts on the neurobiology of attention-deficit/hyperactivity disorder. J Atten Disord 2002, 6(Suppl 1):S7-S16.
4. Barr W.B. Schizophrenia and attention deficit disorder. Two complex disorders of attention. Ann N Y Acad Sci 2001, 931:239-250.
5. Bilder R.M. Schizophrenia as a neurodevelopmental disorder. Curr Opin Psychiatry 2001, 14:9-15.
6. Maedgen J.W., Carlson C.L. Social functioning and emotional regulation in the attention deficit hyperactivity disorder subtypes. J Clin Child Psychol 2000, 29(1):30-42.
7. Edwards J., Jackson H.J., Pattison P.E. Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clin Psychol Rev 2002, 22(6):789-832.
8. Cadesky E.B., Mota V.L., Schachar R.J. Beyond words: how do children with ADHD and/or conduct problems process nonverbal information about affect?. J Am Acad Child Adolesc Psychiatry 2000, 39(9):1160-1167.
9. Aghevli M.A., Blanchard J.J., Horan W.P. The expression and experience of emotion in schizophrenia: a study of social interactions. Psychiatry Res 2003, 119(3):261-270.
10. Green M.J., Waldron J.H., Coltheart M. Emotional context processing is impaired in schizophrenia. Cogn Neuropsychiatry 2007, 12(3):259-280.
11. Penn D.L., Ritchie M., Francis J., Combs D., Martin J. Social perception in schizophrenia: the role of context. Psychiatry Res 2002, 109(2):149-159.
12. Uhlhaas P.J., Phillips W.A., Schenkel L.S., Silverstein S.M. Theory of mind and perceptual context-processing in schizophrenia. Cogn Neuropsychiatry 2006, 11(4):416-436.
13. Uekermann J., Kraemer M., Abdel-Hamid M., Schimmelmann B.G., Hebebrand J., Daum I., et al. Social cognition in attention-deficit hyperactivity disorder (ADHD). Neurosci Biobehav Rev 2010, 34(5):734-743.
14. Murray R.M., Lappin J., Di Forti M., Schizophrenia from developmental deviance to dopamine dysregulation. Eur Neuropsychopharmacol 2008, 18(Suppl 3):S129-S134.
15. Solanto M.V. Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research. Behav Brain Res 2002, 130(1-2):65-71.
16. Keshavan M.S., Sujata M., Mehra A., Montrose D.M., Sweeney J.A. Psychosis proneness and ADHD in young relatives of schizophrenia patients. Schizophr Res 2003, 59(1):85-92.
17. Silverstein M.L., Mavrolefteros G., Turnbull A. Premorbid factors in relation to motor, memory, and executive functions deficits in adult schizophrenia. Schizophr Res 2003, 61(2-3):271-280.
18. Oner O., Munir K. Attentional and neurocognitive characteristics of high-risk offspring of parents with schizophrenia compared with DSM-IV attention deficit hyperactivity disorder children. Schizophr Res 2005, 76(2-3):293-299.
19. Peralta V., de Jalón E.G., Campos M.S., Zandio M., Sanchez-Torres A., Cuesta M.J. The meaning of childhood attention-deficit hyperactivity symptoms in patients with a first-episode of schizophrenia-spectrum psychosis. Schizophr Res 2011, 10.1016/j.schres.2010.09.010.
20. Elman I., Sigler M., Kronenberg J., Lindenmayer J.P., Doron A., Mendlovic S., et al. Characteristics of patients with schizophrenia successive to childhood attention deficit hyperactivity disorder (ADHD). Isr J Psychiatry Relat Sci 1998, 35(4):280-286.
21. Edwards R., Manstead A.S.R., MacDonald C.J. The relationship between children's sociometric status and ability to recognise facial expressions of emotion. Eur J Soc Psychol 1984, 14:235-238.
22. Feldman R.S., Philippot J.R., Custrini R.J. Social competence and nonverbal behaviour. Fundamentals of nonverbal behavior 1991, 329-350. Cambridge University Press, NewYork. R.S. Feldman, B. Rime (Eds.).
23. Philippot P., Feldman R.S. Age and social competence in preschoolers' decoding of facial expression. Br J Soc Psychol 1990, 29(Pt 1):43-54.
24. Brüne M., Brüne-Cohrs U. Theory of mind - evolution, ontogeny, brain mechanisms and psychopathology. Neurosci Biobehav Rev 2006, 30(4):437-455.
25. Solanto M.V. Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav Brain Res 1998, 94(1):127-152.
26. Seeman P. Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses 2010, 4(1):56-73.
27. Russell V.A. Neurobiology of animal models of attention-deficit hyperactivity disorder. J Neurosci Methods 2007, 161(2):185-198.
28. Sagvolden T., Sergeant J.A. Attention deficit/hyperactivity disorder - from brain dysfunctions to behaviour. Behav Brain Res 1998, 94(1):1-10.
29. Sagvolden T., Metzger M.A., Schiørbeck H.K., Rugland A.L., Spinnangr I., Sagvolden G. The spontaneously hypertensive rat (SHR) as an animal model of childhood hyperactivity (ADHD): changed reactivity to reinforcers and to psychomotor stimulants. Behav Neural Biol 1992, 58(2):103-112.
30. Bizot J.C., Chenault N., Houzé B., Herpin A., David S., Pothion S., et al. Methylphenidate reduces impulsive behaviour in juvenile Wistar rats, but not in adult Wistar, SHR and WKY rats. Psychopharmacology (Berl) 2007, 193(2):215-223.
31. Calzavara M.B., Medrano W.A., Levin R., Kameda S.R., Andersen M.L., Tufik S., et al. Neuroleptic drugs revert the contextual fear conditioning deficit presented by spontaneously hypertensive rats: a potential animal model of emotional context processing in schizophrenia?. Schizophr Bull 2009, 35(4):748-759.
32. van den Bergh F.S., Bloemarts E., Chan J.S., Groenink L., Olivier B., Oosting R.S. Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder. Pharmacol Biochem Behav 2006, 83(3):380-390.
33. Calzavara M.B., Medrano W.A., Levin R., Libânio T.C., Ribeiro R., de A., Abílio V.C. The contextual fear conditioning deficit presented by spontaneously hypertensive rats (SHR) is not improved by mood stabilizers. Prog Neuropsychopharmacol Biol Psychiatry 2011, 10.1016/j.pnpbp.2011.06.005.
34. Martin M.V., Dong H., Bertchume A., Csernansky J.G. Low dose quetiapine reverses deficits in contextual and cued fear conditioning in rats with excitotoxin-induced hippocampal neuropathy. Pharmacol Biochem Behav 2005, 82(2):263-269.
35. Pietersen C.Y., Bosker F.J., Doorduin J., Jongsma M.E., Postema F., Haas J.V., et al. An animal model of emotional blunting in schizophrenia. PLoS One 2007, 2(12):e1360.
36. Lubow R.E. Construct validity of the animal latent inhibition model of selective attention deficits in schizophrenia. Schizophr Bull 2005, 31(1):139-153.
37. Swerdlow N.R., Weber M., Qu Y., Light G.A., Braff D.L. Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology (Berl) 2008, 199(3):331-388.
38. Levin R., Calzavara M.B., Santos C.M., Medrano W.A., Niigaki S.T., Abílio V.C. Spontaneously hypertensive rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine. Prog Neuropsychopharmacol Biol Psychiatry 2011, 10.1016/j.pnpbp.2011.06.003.
39. Russell V., de Villiers A., Sagvolden T., Lamm M., Taljaard J. Differences between electrically-, ritalin- and d-amphetamine-stimulated release of [3H]dopamine from brain slices suggest impaired vesicular storage of dopamine in an animal model of Attention-Deficit Hyperactivity Disorder. Behav Brain Res 1998, 94(1):163-171.
40. Carboni E., Silvagni A., Valentini V., Di Chiara G. Effect of amphetamine, cocaine and depolarization by high potassium on extracellular dopamine in the nucleus accumbens shell of SHR rats. An in vivo microdyalisis study. Neurosci Biobehav Rev 2003, 27(7):653-659.
41. Abi-Dargham A., Gil R., Krystal J., Baldwin R.M., Seibyl J.P., Bowers M., et al. Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort. Am J Psychiatry 1998, 155(6):761-767.
42. Laruelle M., Abi-Dargham A., van Dyck C.H., Gil R., D'Souza C.D., Erdos J., et al. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc Natl Acad Sci USA 1996, 93(17):9235-9240.
43. Ferguson S.A., Cada A.M. Spatial learning/memory and social and nonsocial behaviors in the spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rat strains. Pharmacol Biochem Behav 2004, 77(3):583-594.
44. Goto S.H., Conceição I.M., Ribeiro R.A., Frussa-Filho R. Comparison of anxiety measured in the elevated plus-maze, open-field and social interaction tests between spontaneously hypertensive rats and Wistar EPM-1 rats. Braz J Med Biol Res 1993, 26(9):965-969.
45. Ramos A., Kangerski A.L., Basso P.F., Da Silva Santos J.E., Assreuy J., Vendruscolo L.F., et al. Evaluation of Lewis and SHR rat strains as a genetic model for the study of anxiety and pain. Behav Brain Res 2002, 129(1-2):113-123.
46. O'Tuathaigh C.M., Harte M., O'Leary C., O'Sullivan G.J., Blau C., Lai D., et al. Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice. Eur J Neurosci 2010, 31(2):349-358.
47. Sams-Dodd F. Distinct effects of d-amphetamine and phencyclidine on the social behaviour of rats. Behav Pharmacol 1995, 6(1):55-65.
48. Sams-Dodd F., Lipska B.K., Weinberger D.R. Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood. Psychopharmacology (Berl) 1997, 132(3):303-310.
49. Sams-Dodd F. A test of the predictive validity of animal models of schizophrenia based on phencyclidine and D-amphetamine. Neuropsychopharmacology 1998, 18(4):293-304.
50. Sams-Dodd F. Effects of dopamine agonists and antagonists on PCP-induced stereotyped behaviour and social isolation in the rat social interaction test. Psychopharmacology (Berl) 1998, 135(2):182-193.
51. Sams-Dodd F. Effects of continuous d-amphetamine and phencyclidine administration on social behaviour, stereotyped behaviour, and locomotor activity in rats. Neuropsychopharmacology 1998, 19(1):18-25.
52. Ando R.D., Benko A., Ferrington L., Kirilly E., Kelly P.A., Bagdy G. Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test. Neuropharmacology 2006, 50(7):884-896.
53. O'Tuathaigh C.M., O'Connor A.M., O'Sullivan G.J., Lai D., Harvey R., Croke D.T., et al. Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32(2):462-466.
54. Lipska B.K., Weinberger D.R. To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology 2000, 23(3):223-239.
55. Powell C.M., Miyakawa T. Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder?. Biol Psychiatry 2006, 59:1198-1207.
56. van den Buuse M., Garner B., Gogos A., Kusljic S. Importance of animal models in schizophrenia research. Aust N Z J Psychiatry 2005, 39(7):550-557.
57. van den Buuse M. Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects. Schizophr Bull 2010, 36(2):246-270.
58. Hård E., Carlsson S.G., Jern S., Larsson K., Lindh A.S., Svensson L. Behavioral reactivity in spontaneously hypertensive rats. Physiol Behav 1985, 35:487-492.
59. Paré W.P. Open field, learned helplessness, conditioned defensive burying, and forced-swim tests in WKY rats. Physiol Behav 1994, 55(3):433-439.
60. Diana G. Does hypertension alone lead to cognitive decline in spontaneously hypertensive rats?. Behav Brain Res 2002, 134(1-2):113-121.
61. Drolet G., Proulx K., Pearson D., Rochford J., Deschepper C.F. Comparisons of behavioral and neurochemical characteristics between WKY, WKHA, and Wistar rat strains. Neuropsychopharmacology 2002, 27(3):400-409.
62. Rosecrans J.A., Adams M.D. Brain 5-hydroxytryptamine correlates of behavior: studies involving spontaneously hypertensive (SHR) and normotensive Wistar rats. Pharmacol Biochem Behav 1976, 5:559-564.
63. Tilson H.A., Chamberlain J.H., Gylys J.A., Buyniski J.P. Behavioral suppressant effects of clonidine in strains of normotensive and hypertensive rats. Eur J Pharmacol 1977, 43:99-105.
64. McCarty R., Kirby R.F. Spontaneous hypertension and open-field behavior. Behav Neural Biol 1982, 34:450-452.
65. Paré W.P. The performance of WKY rats on three tests of emotional behavior. Physiol Behav 1992, 51(5):1051-1056.
66. Paré W.P. Learning behavior, escape behavior, and depression in an ulcer susceptible rat strain. Integr Physiol Behav Sci 1992, 27(2):130-141.
67. Paré W.P. Passive-avoidance behavior in Wistar-Kyoto (WKY), Wistar, and Fischer-344 rats. Physiol Behav 1993, 54(5):845-852.
68. Dugovic C., Solberg L.C., Redei E., Van Reeth O., Turek F.W. Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression. Neuroreport 2000, 11(3):627-631.
69. Prediger R.D.S., Fernandes D., Takahashi R.N. Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats. Behav Brain Res 2005, 159:197-205.
70. Ramos A., Berton O., Mormède P., Chaouloff F. A multiple-test of anxiety-related behaviors in six inbred rat strains. Behav Brain Res 1997, 85:57-69.
71. Ledoux J.E., Sakaguchi A., Reis D.J. Strain differences in fear between spontaneously hypertensive and normotensive rats. Brain Res 1983, 277(1):137-143.
72. Gentsch C., Lichtsteiner M., Feer H. Open field and elevated plus-maze: a behavioural comparison between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the effects of chlordiazepoxide. Behav Brain Res 1987, 25:101-107.
73. Ramos A., Pereira E., Martins G.C., Wehrmeister T.D., Izídio G.S. Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial. Behav Brain Res 2008, 193:277-288.
74. Calzavara M.B., Lopez G.B., Abílio V.C., Silva R.H., Frussa-Filho R. Role of anxiety levels in memory performance of spontaneously hypertensive rats. Behav Pharmacol 2004, 15:545-553.
75. File S.E., Lippa A.S., Beer B., Lippa M.T. Animal tests of anxiety. Curr Protoc Neurosci 2004, Chapter 8:Unit 8.3.
76. Bouchard R.H., Merette C., Pourcher E., Demers M.F., Villeneuve J., Roy-Gagnon M.H., et al. Longitudinal comparative study of risperidone and conventional neuroleptics for treating patients with schizophrenia. The Quebec Schizophrenia Study Group. J Clin Psychopharmacol 2000, 20:295-304.
77. Miyamoto S., Duncan G.E., Marx C.E., Lieberman J.A. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 2005, 10(1):79-104.
78. Laviola G., Adriani W., Terranova M.L., Gerra G. Psychobiological risk factors for vulnerability to psychostimulants in human adolescents and animal models. Neurosci Biobehav Rev 1999, 23:993-1010.
79. Cailhol S., Mormède P. Strain and sex differences in the locomotor response and behavioral sensitization to cocaine in hyperactive rats. Brain Res 1999, 842:200-205.
80. Hynes M.D., Langer D.H., Hymson D.L., Pearson D.V., Fuller R.W. Differential effects of selected dopaminergic agents on locomotor activity in normotensive and spontaneously hypertensive rats. Pharmacol Biochem Behav 1985, 23:445-448.
81. Van den Buuse M., de Jong W. Differential effects of dopaminergic drugs on open-field behavior of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. J Pharmacol Exp Ther 1989, 248:1189-1196.
82. Knardahl S., Sagvolden T. Regarding hyperactivity of the SHR in the open-field test. Behav Neural Biol 1981, 32:274-275.
83. Simpson S.M., Menard J.L., Reynolds J.N., Beninger R.J. Post-weaning social isolation increases activity in a novel environment but decreases defensive burying and subchronic MK-801 enhances the activity but not the burying effect in rats. Pharmacol Biochem Behav 2010, 95:72-79.
84. Janowsky D.S., Risch C. Amphetamine psychosis and psychotic symptoms. Psychopharmacology 1979, 65:73-77.
85. Yui K., Goto K., Ikemoto S., Ishiguro T., Angrist B., Duncan G.E., et al. Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization. Mol Psychiatry 1999, 4:512-523.
86. Lipska B.K., Jaskiw G.E., Weinberger D.R. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacology 1993, 9:67-75.
87. Lapiz M.D., Fulford A., Muchimapura S., Mason R., Parker T., Marsden C.A. Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission. Neurosci Behav Physiol 2003, 33:13-29.
88. Jentsch J.D., Taylor J.R., Roth R.H. Subchronic phencyclidine administration increases mesolimbic dopaminergic system responsivity and augments stress- and psychostimulant-induced hyperlocomotion. Neuropsychopharmacology 1998, 19:105-113.
89. Green M.J., Waldron J.H., Simpson I., Coltheart M. Visual processing of social context during mental state perception in schizophrenia. J Psychiatry Neurosci 2008, 33:34-42.