Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor

European Journal of Neurology

Volumn 18, Issue 8, 2011, Pages 1085-1089

  Lorenzo Betancor, O ^a,b   Garcia Martin E ^c,d   Cervantes, S ^a,b   Agundez J A G ^c,d   Jimenez Jimenez F J ^e,f   Alonso Navarro, H ^f,g   Luengo, A ^h   Coria, F ⁱ   Lorenzo, E ^a   Irigoyen, J ^b,j   Pastor, P ^a,b,j  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

^c UNIVERSITY OF EXTREMADURA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e UNIVERSITY OF ALCALÁ   (Spain)

^f Hospital del Sureste   (Spain)

^g HOSPITAL GENERAL LA MANCHA CENTRO   (Spain)

^h HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

ⁱ HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^j CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

more..

Author keywords

Association study; Essential tremor; Genetics; LINGO1

Indexed keywords

LINGO 1 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; ESSENTIAL TREMOR; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; LINGO1 GENE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; ESSENTIAL TREMOR; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENOTYPE; HUMANS; MEMBRANE PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; YOUNG ADULT;

EID: 79960307713     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2010.03251.x     Document Type: Article

References (28)

1. Jankovic J. Essential tremor: a heterogenous disorder. Mov Disord 2002; 17: 638-644.
2. Louis ED. Etiology of essential tremor: should we be searching for environmental causes? Mov Disord 2001; 16: 822-829.
3. Gulcher JR, Jonsson P, Kong A, et al. Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. Nat Genet 1997; 17: 84-87.
4. Higgins JJ, Pho LT, Nee LE. A gene (ETM) for essential tremor maps to chromosome 2p22-p25. Mov Disord 1997; 12: 859-864.
5. Shatunov A, Sambuughin N, Jankovic J, et al. Genomewide scans in North American families reveal genetic linkage of essential tremor to a region on chromosome 6p23. Brain 2006; 129: 2318-2331.
6. Garcia-Martin E, Martinez C, Alonso-Navarro H, et al. Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor. Mov Disord 2009; 24: 1910-1915.
7. Jeanneteau F, Funalot B, Jankovic J, et al. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. Proc Natl Acad Sci USA 2006; 103: 10753-10758.
8. Alonso-Navarro H, Martinez C, Garcia-Martin E, et al. CYP2C19 polymorphism and risk for essential tremor. Eur Neurol 2006; 56: 119-123.
9. Martinez C, Garcia-Martin E, Alonso-Navarro H, et al. Glutathione-S-transferase P1 polymorphism and risk for essential tremor. Eur J Neurol 2008; 15: 234-238.
10. Martinez C, Garcia-Martin E, Alonso-Navarro H, et al. Changes at the CYP2C locus and disruption of CYP2C8/9 linkage disequilibrium in patients with essential tremor. Neuromolecular Med 2007; 9: 195-204.
11. Stefansson H, Steinberg S, Petursson H, et al. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet 2009; 41: 277-279.
12. Mi S, Lee X, Shao Z, et al. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 2004; 7: 221-228.
13. Inoue H, Lin L, Lee X, et al. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci USA 2007; 104: 14430-14435.
14. Paisan-Ruiz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004; 44: 595-600.
15. Zimprich A, Biskup S, Leitner P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004; 44: 601-607.
16. Lorenzo-Betancor O, Samaranch L, García-Martín E, et al. LINGO1 gene analysis in Parkinson's disease phenotypes. Mov Disord 2010; n/a. doi: 10.1002/mds. 23452.
17. Deuschl G, Bain P, Brin M. Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord 1998; 13(Suppl. 3): 2-23.
18. Gauderman W, Morrison J. QUANTO 1.1: a computer program for power and sample size calculations for genetic-epidemiology studies. (accessed 25/5/2010). 2006.
19. Tan EK, Teo YY, Prakash KM, et al. LINGO1 variant increases risk of familial essential tremor. Neurology 2009; 73: 1161-1162.
20. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
21. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003; 25: 115-121.
22. Cruchaga C, Vidal-Taboada JM, Ezquerra M, et al. 5′-Upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration. Neurobiol Dis 2009; 33: 164-170.
23. Pastor P, Roe CM, Villegas A, et al. Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred. Ann Neurol 2003; 54: 163-169.
24. Magi R, Morris AP. GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics 2010; 11: 288.
25. Vilarino-Guell C, Wider C, Ross OA, et al. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. Neurogenetics 2010; 11: 401-408.
26. Thier S, Lorenz D, Nothnagel M, et al. LINGO1 polymorphisms are associated with essential tremor in Europeans. Mov Disord 2010; 25: 709-715.
27. Vilariño-Güell C, Ross OA, Wider C, et al. LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. Parkinsonism Relat Disord 2010; 16: 109-111.
28. Clark LN, Park N, Kisselev S, Rios E, Lee JH, Louis ED. Replication of the LINGO1 gene association with essential tremor in a North American population. Eur J Hum Genet 2010; 18: 838-843.