Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway

Oncology Letters

Volumn 2, Issue 5, 2011, Pages 891-897

  Liu, Xiaoxia ^a   Li, Xiaobo ^b   Yin, Lianhua ^b   Ding, Jingxin ^a   Jin, Hongyan ^a   Feng, Youji ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Choriocarcinoma; E cadherin; ER ; Genistein; Invasion; MTA3; Snail

Indexed keywords

ESTROGEN RECEPTOR BETA; GENISTEIN; MESSENGER RNA; METASTASIS ASSOCIATED PROTEIN 3; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SNAIL; TUMOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CARCINOMA CELL; CELL ADHESION; CELL ASSAY; CHORIOCARCINOMA; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

EID: 79960293308     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.338     Document Type: Article

References (29)

1. Jiang SW, Lloyd RV, Jin L and Eberhardt NL: Estrogen receptor expression and growth-promoting function in human choriocarcinoma cells. DNA Cell Biol 16: 969-977, 1997.
2. Fox EM, Davis RJ and Shupnik MA: ERbeta in breast cancer-onlooker, passive player, or active protector? Steroids 73: 1039-1051, 2008.
3. Moggs JG and Orphanides G: Estrogen receptors: orchestrators of pleiotropic cellular responses. EMBO Rep 2: 775-781, 2001.
4. El Shalakany AH, Kamel KM, Ismail AM, Salah L, Deen Fahmy SS and El Deen AE: Estrogen and progesterone receptors and telomerase enzyme immunohistochemical detection in gestational trophoblastic tumors. Int J Gynecol Cancer 16: 1918-1926, 2006.
5. Fujimoto J, Nakagawa Y, Toyoki H, Sakaguchi H, Sato E and Tamaya T: Estrogen-related receptor expression in placenta throughout gestation. J Steroid Biochem Mol Biol 94: 67-69, 2005.
6. Setchell KD: Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68: 1333S-1346S, 1998.
7. Taylor CK, Levy RM, Elliott JC and Burnett BP: The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies. Nutr Rev 67: 398-415, 2009.
8. Szkudelska K and Nogowski L: Genistein - a dietary compound inducing hormonal and metabolic changes. J Steroid Biochem Mol Biol 105: 37-45, 2007.
9. Hohn HP, Grummer R, Bosserhoff S, Graf-Lingnau S, Reuss B, Backer C and Denker HW: The role of matrix contact and of cell-cell interactions in choriocarcinoma cell differentiation. Eur J Cell Biol 69: 76-85, 1996.
10. Zhao HB, Wang C, Li RX, Tang CL, Li MQ, Du MR, Hou XF and Li DJ: E-Cadherin, as a negative regulator of invasive behavior of human trophoblast cells, is down-regulated by cyclosporin A via epidermal growth factor/extracellular signal-regulated protein kinase signaling pathway. Biol Reprod 83: 370-376, 2010.
11. Toh Y and Nicolson GL: The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications. Clin Exp Metastasis 26: 215-227, 2009.
12. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F and Nieto MA: The transcription factor Snail controls epithelial-mesenchymal transitions by suppressing E-cadherin expression. Nat Cell Biol 2: 76-83, 2000.
13. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J and Garcia DH: The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2: 84-89, 2000.
14. Hajra KM and Fearon ER: Cadherin and catenin alterations in human cancer. Genes Chromosomes Cancer 34: 255-268, 2002.
15. Manas ES, Xu ZB, Unwalla RJ and Somers WS: Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods. Structure 12: 2197-2207, 2004.
16. Barnes S: Effect of genistein on in vitro and in vivo models of cancer. J Nutr 125: 777S-783S, 1995.
17. Lamartiniere CA, Moore JB, Brown NM, Thompson R, Hardin MJ and Barnes S: Genistein suppresses mammary cancer in rats. Carcinogenesis 16: 2833-2840, 1995.
18. Messina MJ, Persky V, Setchell KD and Barnes S: Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 21: 113-131, 1994.
19. Kousidou OC, Mitropoulou TN, Roussidis AE, Kletsas D, Theocharis AD and Karamanos NK: Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors. Int J Oncol 26: 1101-1109, 2005.
20. Huang X, Chen S, Xu L, Liu Y, Deb DK, Platanias LC and Bergan RC: Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. Cancer Res 65: 3470-3478, 2005.
21. Xu L, Ding Y, Catalona WJ, Yang XJ, Anderson WF, Jovanovic B, Wellman K, Killmer J, Huang X, Scheidt KA, Montgomery RB and Bergan RC: MEK4 function, genistein treatment, and invasion of human prostate cancer cells. J Natl Cancer Inst 101: 1141-1155, 2009.
22. Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto CH, Helenowski I, Pelling JC and Bergan RC: Dietary genistein inhibits metastasis of human prostate cancer in mice. Cancer Res 68: 2024-2032, 2008.
23. Shao ZM, Wu J, Shen ZZ and Barsky SH: Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Res 58: 4851-4857, 1998.
24. Karmakar S and Das C: Modulation of ezrin and E-cadherin expression by IL-1beta and TGF-beta1 in human trophoblasts. J Reprod Immunol 64: 9-29, 2004.
25. Hajra KM, Chen DY and Fearon ER: The SLUG zinc-finger protein suppresses E-cadherin in breast cancer. Cancer Res 62: 1613-1618, 2002.
26. Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS and Wade PA: MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 113: 207-219, 2003.
27. Saji S, Hirose M and Toi M: Clinical significance of estrogen receptor beta in breast cancer. Cancer Chemother Pharmacol 56 (Suppl 1): 21-26, 2005.
28. Cheng J, Lee EJ, Madison LD and Lazennec G: Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis. FEBS Lett 566: 169-172, 2004.
29. Barnes S, Boersma B, Patel R, Kirk M, Darley-Usmar VM, Kim H and Xu J: Isoflavonoids and chronic disease: mechanisms of action. Biofactors 12: 209-215, 2000.