Localization of glucocorticoid hormone receptors in mitochondria of human cells

European Journal of Cell Biology

Volumn 79, Issue 5, 2000, Pages 299-307

  Scheller, Klaus ^a,c   Sekeris, Constantin E ^b   Krohne, Georg ^a   Hock, Robert ^a   Hansen, Immo A ^a   Scheer, Ulrich ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Glucocorticoid receptor; Green fluorescent protein; HeLa cells; Hep 2 cells; Immunolocalization; Mitochondria

Indexed keywords

CYTOCHROME C OXIDASE; DYE; ENZYME ANTIBODY; GLUCOCORTICOID RECEPTOR; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN;

ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; ELECTRON MICROSCOPY; HELA CELL; HEP 2 CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; IMMUNOGOLD STAINING; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EUKARYOTA;

EID: 0034082961     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/S0171-9335(04)70033-3     Document Type: Article

References (50)

1. Akner, G., Sundquist, K.-G., Denis, M., Wikström, A.-C., Gustafsson, J.-A. (1990): Immunocytochemical localization of glucocorticoid receptor in human gingival fibroblasts and evidence for a colocalization of glucocorticoid receptor with cytoplasmic microtubules. Eur. J. Cell Biol. 53, 390-401.
2. Akner, G., Wikström, A. C., Gustafsson, J. A. (1995): Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules. J. Steroid Biochem. Mol. Biol. 52, 1-16.
3. Beato, M., Herrlich, P., Schütz, G. (1995): Steroid hormone receptors: many actors in search of a plot. Cell 83, 851-857.
4. Brink, M., Humbel, B. M., de Kloet, E. R., van Driel, R. (1992): The unliganded glucocorticoid receptor is localized in the nucleus, not in the cytoplasma. Endocrinology 130, 3575-3580.
5. Carey, K. L., Richards, S. A., Lounsbury, K. M., Macara, I. G. (1996): Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the RAN/TC4 GTPase mediates an essential function independent of nuclear protein import. J. Cell Biol. 133, 985-996.
6. Casas, F., Rochard, P., Rodier, A., Cassar-Malek, I., Marchal-Victorion, S., Wiesner, R. J., Cabello, G., Wrutniak, C. (1999): A variant form of the nuclear triiodothyroninc recptor c-ErbAa1 plays a direct role in regulation of mitochondrial RNA synthesis. Mol. Cell. Biol. 19, 7913-7924.
7. Cornwall, G. A., Orgebin-Crist, M. C., Hann, S. R. (1992): Differential expression of the mouse mitochondrial genes and the mitochondrial RNA processing endoribonuclease RNA by androgens. Mol. Endocrinol. 6, 1032-1042.
8. DeFranco, D. B., Madan, A. P., Tang, Y., Chandran, U. R., Xiao, N., Yang, J. (1995): Nucleoplasmic shuttling of steroid receptors. In: Vitamins and Hormones Vol. 51, G. Litwack, ed., Academic Press, New York, 315-338.
9. Demonacos, C. V., Tsawdaroglou, N. C., Djordjevic-Marcovic, R., Papalopoulou, M., Galanopolous, V., Papadogeorkagi, S., Sekeris, C. E. (1993): Import of the glucocorticoid receptor into rat liver mitochondria in vivo and in vitro. J. Steroid Biochem. Mol. Biol. 46, 401-413.
10. Demonacos, C. V., Karayanni, N., Hatzoglou, E., Tsiriyiotis, C., Spandidos, D. A., Sekeris, C. E. (1996a): Mitochondrial genes as sites of primary action of steroid hormones. Steroids 61, 226-232.
11. Demonacos, C., Djordjevic-Markovic, R., Tsawdaroglou, N., Sekeris, C. E. (1996b): The mitochondrion as a primary site of action of glucocorticoids: the interaction of the glucocorticoid receptor with mitochondrial DNA sequences showing partial similarity to the nuclear glucocorticoid responsive elements. J. Steroid Biochem. Mol. Biol. 55, 43-55.
12. Enríquez, J. A., Fernández-Silva, P., Garrido-Pérez, N., López-Pérez, M. J., Pérez-Martoz, A., Montoya, J. (1999): Direct regulation of mitochondrial RNA synthesis by thyroid hormone. Mol. Cell. Biol. 19, 657-670.
13. Evans, R. M. (1988): The steroid and thyroid receptors superfamily. Science 240, 889-895.
14. Fejes-Tóth, G., Pearce, D., Náraj-Fejes-Tóth, A. (1998): Subcellular localization of mineralocorlicoid receptors in living cells: Effects of receptor agonists and antagonists. Proc. Natl. Acad. Sci. USA 95, 2973-2978.
15. Flierl, A., Reichmann, H., Seibel, P. (1997): Pathophysiology of the MELAS 3243 transition mutation. J. Biol. Chem. 272, 27189-27196.
16. Greenamyre, J. T., Betrabet, R., MacKenzie, G., Garcia-Osuna, M. (2000): Mitochondrial function in Parkinson's disease. Keystone Symposium on "Mitochondrial Dysfunction in Pathogenesis", Santa Fe (USA), Jan. 15-20. abstract map. p48.
17. Griffith, G., McDowall, A., Back, R., Dubochet, J. (1984): On the preparation of cryosections for immunocytochemistry. J. Ultrastruct. Res. 89, 65-78.
18. Guichon-Mantel, A., Lescop, P., Christin-Maitre, S., Loosfelt, H., Perrot-Applanat, M., Milgrom, E. (1990): Nucleocytoplasmic shuttling of the progesterone receptor. EMBO J. 10, 3851-3859.
19. Hatzoglou, E., Sekeris, C. E. (1997): The detection of nucleotide sequences with strong similarity to the response elements in the genome of eubacteria and archaebacteria and their possible relation to similar sequences present in the mitochondrial genome. J. Theor. Biol. 184, 339-344.
20. Heck, S., Kullmann, M., Gast, A., Ponta, H., Rahmsdorf, H. J., Herrlich, P., Cato, A. C. (1994): A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J. 13, 4087-4095.
21. Heery, D. M., Kalskhoven, E., Hoare, S., Parker, M. G. (1997): A signature motif in transcriptional coactivators mediates binding to nuclear receptors. Nature 387, 733-736.
22. Hsu, S. C., Qi, M., DeFranco, D. B. (1992): Cell cycle regulation of glucocorticoid receptor function. EMBO J. 11, 3457-3468.
23. Htun, H., Barsony, J., Renyi, I., Gould, D. L., Hager, G. L. (1996): Visualization of glucocorticoid receptor translocation and intra-nuclear organization in living cells with a green fluorescent protein chimera. Proc. Natl. Acad. Sci. USA 93, 4845-4850.
24. Jewell, C. M., Webster, J. C., Burnstein, K. L., Sar, M., Bodwell, J. E., Cidlowski, J. A. (1995): Immunocytochemical analysis of hormone mediated nuclear translocation of wild type and mutant glucocorticoid receptors. J. Steroid Mol. Biol. 55, 135-146.
25. Katowski, J., Kitawaga, J. (1988): Enhanced transcription of mitochondrial genes after growth stimulation and glucocorticoid treatment of Reuber hepatoma H35 cells. FEBS Lett. 233, 51-86.
26. Klapper, M., Exner, K., Kempf. A., Gehring, C., Stuurman, N., Fisher, P. A., Krohne, G. (1997): Assembly of A- and B-type lamins studied in vivo with the baculovirus system. J. Cell Sci. 110, 2519-2532.
27. Kroemer, G., Petit, P. X., Zamzami, N., Vassière, J., Mignotte, B. (1995): The biochemistry of programmed cell death. FASEB J. 9, 1277-1287.
28. Migliaccio, A., Piccolo, D., Castoria, G., DiDomenico, M., Bilancio, A., Lombardi, M., Gong, W., Beato, M., Auricchio, F. (1998): Activation of the SRC/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor. EMBO J. 17, 2008-2018.
29. Mutvei, A., Kuzela, S., Nelson, B. D. (1989): Control of mitochondrial transcription by thyroid hormone. Eur. J. Biochem. 180, 235-240.
30. Nagley, P. (1991) Coordination of gene expression in the formation of mammalian mitochondria. Trends Genet. 7, 1-4.
31. Nelson, B. D. (1990): Thyroid hormone regulation of mitochondrial function. Comments on the mechanism of signal transduction. Biochim. Biophys. Acta 1018, 275-277.
32. Papamichail, M., Tsokos, G., Tsawdaroglou, N., Sekeris, C. E. (1980): Immunocytological demonstration of glucocorticoid receptors in different cell types and their translocation from the cytoplasm to the nucleus in the presence of dexamethasone. Exp. Cell Res. 125, 480-495.
33. Pelzer, T., Schumann, M., Neumann, M., deJager, T., Stimpel, M., Serfling, E., Neyses, L. (2000): 17-b estradiol prevents programmed cell death in cardiac myocytes. Biochem. Biophys. Res. Commun. (in press).
34. Picard, D., Yamamoto, K. R. (1987): Two signals mediate hormone-dependent nuclear localisation of the glucocorticoid receptor. EMBO J. 6, 3333-3340.
35. Rogatzki, I., Logan, S. K., Garabedian, M. J. (1498): Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 95, 2050-2055.
36. Sheppard, K.-A., Phelps, K. M., Williams, A. J., Thanos, D., Glass, C. K., Rosenfeld, M. G., Gerritsen, M. E., Collins, T. (1998): Nuclear integration of glucocorticoid receptor and nuclear factor kappaB signaling by CREB-binding protein and steroid receptor coactivator-1. J. Biol. Chem. 273, 29291-29294.
37. Stuart, R. A., Neupert, W. (1996): Topogenesis of inner membrane proteins of mitochondria. Trends Biochem. Sci. 21, 261-275.
38. Taylor, R. W., Birch Machin, R. A., Bartlett, K., Turnbull, D. M. (1993): Succinate cytochrome c oxidase: assessment of its value in the investigation of defects of the respiratory chain. Biochim. Biophys. Acta 1181, 261-265.
39. Torchia, J., Rose, D. W., Inostroza, J., Kamei, Y., Westin, S., Glass, C. K., Rosenfeld, M. G. (1997): The transcriptional co-activator p/CIP binds CBP and mediates nuclear receptor function. Nature 387, 677-684.
40. Tsai, M. J., O'Malley, B. W. (1994): Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63, 451-486.
41. Van Itallie, C. M. (1992): Dexamethasone treatment increases mitochondrial RNA synthesis in a rat hepatoma cell line. Endocrinology 30, 567-576.
42. Van Steensel, B., Brink, M., van der Meulen, K., van Binnendijk, E. P., Wansink, D. G., de Jong, L., de Kloet, E. R., van Driel, R. (1995): Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus. J. Cell Sci. 108, 3003-3011.
43. Westphal, H. M., Moldenhauer, G., Beato, M. (1982): Monoclonal antibodies to the rat liver glucocorticoid receptor. EMBO J. 1, 1467-1471.
44. Westphal, H. M., Mugele, K., Beato, M., Gehring, U. (1984): Immunochemical characterization of wild-type and variant glucocorticoid receptor by monoclonal antibodies. EMBO J. 3, 1493-1498.
45. Whitaker, J. E., Moore, P. L., Haugland, R. P. (1991): Dihydrotetramethylrosamine: a long wavelength, fluorogenic peroxidase substrate evaluated in vitro. Biochem. Biophys. Res. Commun. 1675, 387-393.
46. Wiesner, R. J., Kurowski, T. T., Zak, R. (1992): Regulation by thyroid hormone of nuclear and mitochondrial genes encoding subunits of cytochrome c oxidase in rat liver and skeletal muscle. Mol. Endocrinol. 6, 1454-1467.
47. Wrutniak, C., Cassar-Malek, I., Marchai, S., Rascle, A., Heusser, S., Keller, J.-M., Fléchon, J., Dauca, M., Samarut, J., Ghysdael, J., Cabello, G., (1995): A 43-kDa protein related to c-Erb A α1 is located in the mitochondrial matrix of rat liver. J. Biol. Chem. 270, 16347-16354.
48. Wrutniak, C., Rochard, P., Casas, F., Fraysse, A., Charrier, J., Cabello, G. (1998): Physiological importance of the T3 mitochondrial pathway. Ann. N. Y. Acad. Sci. 839, 93-100.
49. Yamamoto, K. R. (1985): Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19, 209-215.
50. Yang, J., Liu, J., DeFranco, D. B. (1997): Subnuclear trafficking of glucocorticoid receptors in vitro: chromatin recycling and nuclear export. J. Cell Biol. 137, 523-538.