Unraveling androgen action in muscle: Genetic tools probing cellular mechanisms

Endocrinology

Volumn 150, Issue 8, 2009, Pages 3437-3439

  MacLean, Helen E ^a   Handelsman, David J ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TESTOSTERONE;

AGING; DOPING; GENE INACTIVATION; HUMAN; MEDICAL RESEARCH; MUSCLE CELL; MUSCLE CONTRACTION; MUSCLE FUNCTION; MUSCLE HYPERTROPHY; MUSCLE MASS; MUSCLE STRENGTH; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; SKELETAL MUSCLE;

ANIMALS; GLYCOGEN; INTRA-ABDOMINAL FAT; MICE; MUSCLE CELLS; MUSCLE FATIGUE; MUSCLE FIBERS, SKELETAL; MUSCLE STRENGTH; MUSCLES; RECEPTORS, ANDROGEN; SATELLITE CELLS, SKELETAL MUSCLE;

EID: 67651174542     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0438     Document Type: Short Survey

References (28)

1. Sjöqvist F, Garle M, Rane A 2008 Use of doping agents, particularly anabolic steroids, in sports and society. Lancet 371:1872-1882
2. Elashoff JD, Jacknow AD, Shain SG, Braunstein GD 1991 Effects of anabolic-androgenic steroids on muscular strength. Ann Intern Med 115:387-393
3. Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, Bunnell TJ, Tricker R, Shirazi A, Casaburi R 1996 The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 335:1-7
4. Handelsman DJ, Heather A 2008 Androgen abuse in sports. Asian J Androl 10:403-415
5. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, Chen X, Yarasheski KE, Magliano L, Dzekov C, Dzekov J, Bross R, Phillips J, Sinha-Hikim I, Shen R, Storer TW 2001 Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab 281:E1172-E1181
6. Bhasin S, Woodhouse L, Casaburi R, Singh AB, Mac RP, Lee M, Yarasheski KE, Sinha-Hikim I, Dzekov C, Dzekov J, Magliano L, Storer TW 2005 Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab 90:678-688
7. Bhasin S, Storer TW, Javanbakht M, Berman N, Yarasheski KE, Phillips J, Dike M, Sinha-Hikim I, Shen R, Hays RD, Beall G 2000 Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. JAMA 283:763-770
8. Creutzberg EC, Wouters EF, Mostert R, Pluymers RJ, Schols AM 2003 A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial. Chest 124:1733-1742
9. Macdonald JH, Marcora SM, Jibani MM, Kumwenda MJ, Ahmed W, Lemmey AB 2007 Nandrolone decanoate as anabolic therapy in chronic kidney disease: a randomized phase II dose-finding study. Nephron Clin Pract 106:c125-135
10. Wolf SE, Edelman LS, Kemalyan N, Donison L, Cross J, Underwood M, Spence RJ, Noppenberger D, Palmieri TL, Greenhalgh DG, Lawless M, Voigt D, Edwards P, Warner P, Kagan R, Hatfield S, Jeng J, Crean D, Hunt J, Purdue G, Burris A, Cairns B, Kessler M, Klein RL, Baker R, Yowler C, Tutulo W, Foster K, Caruso D, Hildebrand B, Benjamin W, Villarreal C, Sanford AP, Saffle J 2006 Effects of oxandrolone on outcome measures in the severely burned: a multicenter prospective randomized double-blind trial. J Burn Care Res 27:131-139; discussion 140-131
11. Liverman CT, Blazer DG, eds. 2004 Testosterone and aging: clinical research directions. Washington, DC: Institute of Medicine, National Academies Press
12. MacLean HE, Warne GL, Zajac JD 1997 Localization of functional domains in the androgen receptor. J Steroid Biochem Mol Biol 62:233-242
13. Heinlein CA, Chang C 2002 Androgen receptor (AR) coregulators: an overview. Endocr Rev 23:175-200
14. Quigley CA, De Bellis A, Marschke KB, el-Awady MK, Wilson EM, French FS 1995 Androgen receptor defects: historical, clinical and molecular perspectives. Endocr Rev 16:271-321
15. Gao W, Dalton JT 2007 Ockham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5α-reductase? Mol Interv 7:10-13
16. Jones ME, Boon WC, Proietto J, Simpson ER 2006 Of mice and men: the evolving phenotype of aromatase deficiency. Trends Endocrinol Metab 17:55-64
17. Heinlein CA, Chang C 2002 The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol 16:2181-2187
18. Dalton JT, Mukherjee A, Zhu Z, Kirkovsky L, Miller DD 1998 Discovery of nonsteroidal androgens. Biochem Biophys Res Commun 244:1-4
19. Chen J, Kim J, Dalton JT 2005 Discovery and therapeutic promise of selective androgen receptor modulators. Mol Interv 5:173-188
20. Singh R, Artaza JN, Taylor WE, Gonzalez-Cadavid NF, Bhasin S 2003 Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology 144:5081-5088
21. Joubert Y, Tobin C 1995 Testosterone treatment results in quiescent satellite cells being activated and recruited into cell cycle in rat levator ani muscle. Dev Biol 169:286-294
22. Chen Y, Lee NK, Zajac JD, MacLean HE 2008 Generation and analysis of an androgen-responsive myoblast cell line indicates that androgens regulate myotube protein accretion. J Endocrinol Invest 31:910-918
23. Lyon MF, Hawkes SG 1970 X-linked gene for testicular feminization in the mouse. Nature 227:1217-1219
24. MacLean HE, Chiu WS, Notini AJ, Axell AM, Davey RA, McManus JF, Ma C, Plant DR, Lynch GS, Zajac JD 2008 Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. FASEB J 22:2676-2689
25. Ophoff J, Van Proeyen K, Callewaert F, De Gendt K, De Bock K, Vanden Bosch A, Verhoeven G, Hespel P, Vanderschueren D 2009 Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. Endocrinology 150:3558-3566
26. Antal MC, Krust A, Chambon P, Mark M 2008 Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERβ-null mutant. Proc Natl Acad Sci USA 105:2433-2438
27. Callewaert F, Venken K, Ophoff J, De Gendt K, Torcasio A, van Lenthe GH, Van Oosterwyck H, Boonen S, Bouillon R, Verhoeven G, Vanderschueren D 2009 Differential regulation of bone and body composition in male mice with combined inactivation of androgen and estrogen receptor-α. FASEB J 23:232-240
28. Robling AG, Castillo AB, Turner CH 2006 Biomechanical and molecular regulation of bone remodeling. Annu Rev Biomed Eng 8:455-498