Free DNA and carcinoembryonic antigen serum levels: An important combination for diagnosis of colorectal cancer

Clinical Cancer Research

Volumn 12, Issue 23, 2006, Pages 6985-6988

  Flamini, Emanuela ^a   Mercatali, Laura ^b   Nanni, Oriana ^b   Calistri, Daniele ^b   Nunziatini, Roberta ^a   Zoli, Wainer ^a   Rosetti, Paola ^a   Gardini, Nice ^a   Lattuneddu, Arturo ^a   Verdecchia, Giorgio Maria ^a   Amadori, Dino ^c  

^a MORGAGNI PIERANTONI HOSPITAL   (Italy)

^b ISTITUTO ONCOLOGICO ROMAGNOLO   (Italy)

^c DEPARTMENT OF MEDICAL ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; DNA;

ADULT; AGED; ALGORITHM; ARTICLE; BLOOD SAMPLING; CALCULATION; COLORECTAL CANCER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; AREA UNDER CURVE; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; DNA; FEMALE; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROC CURVE; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 33845805706     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-1931     Document Type: Article

References (27)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108.
2. Desch CE, Benson AB III, Somerfield MR, et al. Colorectal cancer surveillance: 2005 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol 2005;23:8512-9.
3. Bromer MQ, Weinsberg DS. Screening for colorectal cancer-now and the near future. Semin Oncol 2005; 32:3-10.
4. Bast RC, Ravdin P, Hayes DF, et al. 2000 Update of recommendations for the use of tumor markers in breast and colorectal cancer: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 2001;19:1865-78.
5. Kopreski MS, Benko FA, Borys DJ, Khan A, McGarrity TJ, Gocke CD. Somatic mutation screening: identification of individuals harboring k-ras mutations with the use of plasma DNA. J Natl Cancer Inst 2000; 92:918-23.
6. Fernandes CL, Kim SB, Matos D. Cytokeratins and carcinoembryonic antigen in diagnosis, staging, and prognosis of colorectal adenocarcinoma. World J Gastroenterol 2005;11:645-8.
7. Carpelan-Holmstrom M, Louhimo J, Stenman UA, Alfthan H, Jarvinen H, Haglund C. Estimating the probability of cancer with several tumor markers in patients with colorectal disease. Oncology 2004;66: 296-302.
8. Duffy MJ, van Dalen A, Haglund C, et al. Clinical utility of biochemical markers in colorectal cancer: European group on tumor markers (EGTM) guidelines. Eur J Cancer 2003;39:718-27.
9. Sozzi G, Conte D, Mariani L, et al. Analysis of circulating DNA in plasma at diagnosis and during follow up of lung cancer patients. Cancer Res 2001;61: 4675-8.
10. Sozzi G, Conte D, Leon ME, et al. Quantification of free circulating DNA as a diagnostic marker in lung cancer. J Clin Oncol 2003;21:3902-8.
11. Gautschi O, Bigoschi C, Huegli B, et al. Circulating deoxyribonucleic acid as prognostic marker in non small-cell lung cancer patients undergoing chemotherapy. J Clin Oncol 2004;22:4157-64.
12. Gai S, Fidler C, Lo YMD, et al. Quantification of circulating DNA in the serum of breast cancer patients by real-time PCR. Br J Cancer 2004;90: 1211-5.
13. Leon SA, Shapiro B, Sklaroff DM, Yaros MJ. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 1977;37:646-50.
14. Shapiro B, Chakrabarty M, Cohn EM. Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease. Cancer 1983;51: 2116-20.
15. Thijssen MA, Swinkels DW, Ruers TJ, de Kok JB. Difference between free circulating plasma and serum DNA in patients with colorectal liver metastases. Anticancer Res 2002;22:421-5.
16. Garcia-Olmo D, Garcia-Olmo DC. Functionality of circulating DNA. The hypothesis of genometastasis. Ann N Y Acad Sci 2001;945:265-75.
17. Johnson PJ, Lo DYM. Plasma nucleic acids in diagnosis and management of malignant disease. Clin Chem 2002;48:1186-93.
18. Stroun M, Lyauter J, Lederrey C, Olson-Sand A, Anker P. About the possible origin and mechanism of circulating DNA apoptosis and active DNA release. Clin Chim Acta 2001;313:139-42.
19. Heid CA, Stevens J, Livak K, Williams PM. Real time quantitative PCR. Genome Res 1996;8:2883-9.
20. Baker MK, Mikhitarian K, Osta W, et al. Molecular detection of breast cancer cells in the peripheral blood of advanced-stage breast cancer patients using multimarker real-time reverse transcription-polymerase chain reaction and a novel porous barrier density gradient centrifugation technology. Clin Cancer Res 2003;9:4865-71.
21. Gillanders WE, Mikhitarian K, Hebert R, et al. Molecular detection of micrometastatic breast cancer in histopathology-negative axillary lymph nodes correlates with traditional predictors of prognosis: an interim analysis of a prospective multi-institutional cohort study. Ann Surg 2004;239:828-37.
22. Metz CE. Basic principles of ROC analysis. Semin Nucl Med 1978;8:283-98.
23. Armitage P, Berry G. Statistical methods in medical research. 2nd ed. Boston (MA): Blackwell Scientific Publications: 1987: p. 387-93.
24. Tong YK, Lo YM. Diagnostic developments involving cell-free (circulating) nucleic acids. Clin Chim Acta 2006;363:187-96.
25. Calistri D, Rengucci C, Lattuneddu A, et al. Detection of colorectal cancer by a quantitative fluorescence determination of DNA amplification in stool. Neoplasia 2004;6:536-40.
26. Calistri D, Rengucci C, Bocchini R, Saragoni L, Zoli W, Amadori D. Fecal multiple molecular tests to detect colorectal cancer in stool. Clin Gastroenterol Hepatol 2003;1:377-83.
27. Rengucci C, Maiolo P, Saragoni L, Zoli W, Amadori D, Calistri D. Multiple detection of genetic alterations in tumors and stool. Clin Cancer Res 2001;7:590-3.