Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center

Biochemistry

Volumn 50, Issue 28, 2011, Pages 6280-6288

  Ruiz Carrillo, David ^a,b   Koch, Birgit ^a   Parthier, Christoph ^b   Wermann, Michael ^a   Dambe, Tresfore ^c   Buchholz, Mirko ^a   Ludwig, Hans Henning ^a   Heiser, Ulrich ^a   Rahfeld, Jens Ulrich ^a   Stubbs, Milton T ^b   Schilling, Stephan ^a   Demuth, Hans Ulrich ^a  

^a PROBIODRUG AG   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c PSF AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; ACTIVE CENTER; ALZHEIMER'S DISEASE; BINDING CONSTANT; BINDING DETERMINANT; CYCLASES; CYSTEINE RESIDUES; DISULFIDE BONDS; GLUTAMINYL; GLYCOSYLATED; MULTIPLE ORIENTATIONS; N-TERMINALS; POST-TRANSLATIONAL MODIFICATIONS; SITE DIRECTED MUTAGENESIS; SUBSTRATE CONVERSION; SURFACE LOOPS; TRYPTOPHAN RESIDUES; ZINC IONS;

AMINO ACIDS; COVALENT BONDS; MAMMALS; MUTAGENESIS;

CRYSTAL STRUCTURE;

CYSTEINE; ENZYME; GLUTAMINE; GLYCOSYLATED MAMMALIAN GLUTAMINYL CYCLASE; LEUCINE; TRYPTOPHAN; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; HUMAN; HYDROPHOBICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINOACYLTRANSFERASES; ANIMALS; CATTLE; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ESCHERICHIA COLI; GLYCOSYLATION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PICHIA; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; SHEEP;

MAMMALIA; MURINAE; MUS;

EID: 79960249679     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200249h     Document Type: Article

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